Cytokines and transcription factors that regulate T helper cell differentiation: new players and new insights. (Q35150010)

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4 November 2019

review article

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title

Cytokines and transcription factors that regulate T helper cell differentiation: new players and new insights (English)

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4 November 2019

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3

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4 November 2019

author name string

Davide Agnello

1

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4 November 2019

Carla S R Lankford

2

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4 November 2019

Akio Morinobu

4

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4 November 2019

Massimo Gadina

5

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4 November 2019

John J O'Shea

6

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4 November 2019

David M Frucht

7

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4 November 2019

publication date

1 May 2003

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Journal of Clinical Immunology

4 November 2019

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12797537%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

volume

23

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4 November 2019

issue

3

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4 November 2019

page(s)

147-161

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https://scigraph.springernature.com/pub.10.1023/a:1023381027062

4 November 2019

exact match

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The intensity of T cell receptor engagement determines the cytokine pattern of human allergen-specific T helper cells.

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Cutting edge: differential requirements for Stat4 in expression of glycosyltransferases responsible for selectin ligand formation in Th1 cells

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Transcription factor GATA-3 is required for development of the T-cell lineage

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Gene silencing quantitatively controls the function of a developmental trans-activator

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A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival.

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Single cell analysis reveals that IL-4 receptor/Stat6 signaling is not required for the in vivo or in vitro development of CD4+ lymphocytes with a Th2 cytokine profile

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TSLP: finally in the limelight

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Characterization of IL-12 receptor beta1 chain (IL-12Rbeta1)-deficient mice: IL-12Rbeta1 is an essential component of the functional mouse IL-12 receptor

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Cutting edge: distal regulatory elements are required to achieve selective expression of IFN-gamma in Th1/Tc1 effector cells

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Role of T-bet in commitment of TH1 cells before IL-12-dependent selection.

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Cooperative DNA binding and sequence-selective recognition conferred by the STAT amino-terminal domain

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Cutting edge: changes in histone acetylation at the IL-4 and IFN-gamma loci accompany Th1/Th2 differentiation

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Characterization of cis-regulatory elements and nuclear factors conferring Th2-specific expression of the IL-5 gene: a role for a GATA-binding protein.

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T helper type 2 cell differentiation occurs in the presence of interleukin 12 receptor beta2 chain expression and signaling

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Cloning and characterization of a mouse IL-12 receptor-beta component.

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Activated STAT4 has an essential role in Th1 differentiation and proliferation that is independent of its role in the maintenance of IL-12R beta 2 chain expression and signaling

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12 December 2020

GATA-3 induces T helper cell type 2 (Th2) cytokine expression and chromatin remodeling in committed Th1 cells

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12 December 2020

Regulation of IL-4 gene expression by distal regulatory elements and GATA-3 at the chromatin level

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12 December 2020

Severe mycobacterial and Salmonella infections in interleukin-12 receptor-deficient patients

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SAP controls T cell responses to virus and terminal differentiation of TH2 cells.

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Th2 lineage commitment and efficient IL-4 production involves extended demethylation of the IL-4 gene.

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Importance of the MKK6/p38 pathway for interleukin-12-induced STAT4 serine phosphorylation and transcriptional activity

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12 December 2020

Stat4 regulates multiple components of IFN-gamma-inducing signaling pathways

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T(H) cell differentiation is accompanied by dynamic changes in histone acetylation of cytokine genes.

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T-bet is rapidly induced by interferon-gamma in lymphoid and myeloid cells

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12 December 2020

Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function

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Interleukin 21 prevents antigen-induced IgE production by inhibiting germ line C(epsilon) transcription of IL-4-stimulated B cells

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c-maf promotes T helper cell type 2 (Th2) and attenuates Th1 differentiation by both interleukin 4-dependent and -independent mechanisms

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A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R

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Molecular events involved in regulating human interferon-gamma gene expression during T cell activation

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B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: application to autoimmune disease therapy

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Friend of GATA is expressed in naive Th cells and functions as a repressor of GATA-3-mediated Th2 cell development

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12 December 2020

Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4

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12 December 2020

Partial impairment of cytokine responses in Tyk2-deficient mice

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12 December 2020

Targeted disruption of the GATA3 gene causes severe abnormalities in the nervous system and in fetal liver haematopoiesis

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12 December 2020

Regulation of the interleukin (IL)-12R beta 2 subunit expression in developing T helper 1 (Th1) and Th2 cells

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12 December 2020

Ectopic expression of activated Stat6 induces the expression of Th2-specific cytokines and transcription factors in developing Th1 cells

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12 December 2020

Structure and specificity of GATA proteins in Th2 development

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12 December 2020

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins

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12 December 2020

A novel transcription factor, T-bet, directs Th1 lineage commitment

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12 December 2020

The transcription factor c-Maf controls the production of interleukin-4 but not other Th2 cytokines

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12 December 2020

Critical role for STAT4 activation by type 1 interferons in the interferon-gamma response to viral infection

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12 December 2020

Stat6-independent GATA-3 autoactivation directs IL-4-independent Th2 development and commitment.

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12 December 2020

Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin

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12 December 2020

Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes

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12 December 2020

The role of Stat4 in species-specific regulation of Th cell development by type I IFNs.

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12 December 2020

The biology of Stat4 and Stat6

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12 December 2020

Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12

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12 December 2020

Antibodies to the IL-12 receptor beta 2 chain mark human Th1 but not Th2 cells in vitro and in vivo

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12 December 2020

Triggering of T cell proliferation through CD28 induces GATA-3 and promotes T helper type 2 differentiation in vitro and in vivo

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12 December 2020

Functional diversity of helper T lymphocytes

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12 December 2020

Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet

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12 December 2020

Atopy and mutations of IL-12 receptor beta 2 chain gene

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12 December 2020

The p38 mitogen-activated protein kinase is required for IL-12-induced IFN-gamma expression

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12 December 2020

Signal transducer and activator of transcription factor 6 (Stat6)-deficient mice are protected from antigen-induced airway hyperresponsiveness and mucus production

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12 December 2020

The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells

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12 December 2020

The cell type-specific expression of the murine IL-13 gene is regulated by GATA-3

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12 December 2020

IL-12-deficient mice are defective in IFN gamma production and type 1 cytokine responses

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12 December 2020

Helper T cells regulate type-2 innate immunity in vivo

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Interleukin-12: basic principles and clinical applications.

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A critical role for IL-21 in regulating immunoglobulin production

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Cutting edge: chromatin remodeling at the IL-4/IL-13 intergenic regulatory region for Th2-specific cytokine gene cluster

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12 December 2020

GATA-3 significantly downregulates IFN-gamma production from developing Th1 cells in addition to inducing IL-4 and IL-5 levels

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12 December 2020

The IL-4 receptor: signaling mechanisms and biologic functions

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12 December 2020

Control of inflammation, cytokine expression, and germinal center formation by BCL-6

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12 December 2020

Jak2 is essential for signaling through a variety of cytokine receptors

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12 December 2020

Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain

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12 December 2020

Identification of IL-4 promoter elements conferring Th2-restricted expression during T helper cell subset development

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12 December 2020

Molecular mechanisms regulating Th1 immune responses

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12 December 2020

Regulation of Th2 cell differentiation by mel-18, a mammalian polycomb group gene

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12 December 2020

Friend of GATA-1 represses GATA-3-dependent activity in CD4+ T cells.

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12 December 2020

Positive regulatory role of IL-12 in macrophages and modulation by IFN-gamma

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12 December 2020

ROG, repressor of GATA, regulates the expression of cytokine genes

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12 December 2020

IL-21 limits NK cell responses and promotes antigen-specific T cell activation: a mediator of the transition from innate to adaptive immunity

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12 December 2020

Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells

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12 December 2020

Th1 cells regulate hematopoietic progenitor cell homeostasis by production of oncostatin M

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12 December 2020

A T-cell specific TCR delta DNA binding protein is a member of the human GATA family

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12 December 2020

Expression of the transcription factor GATA-3 is required for the development of the earliest T cell progenitors and correlates with stages of cellular proliferation in the thymus

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Identification of a Coordinate Regulator of Interleukins 4, 13, and 5 by Cross-Species Sequence Comparisons

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IL-23 and IL-12 have overlapping, but distinct, effects on murine dendritic cells

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IL-23: a cytokine that acts on memory T cells

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NFATc2 and NFATc3 regulate T(H)2 differentiation and modulate TCR-responsiveness of naïve T(H)cells

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12 December 2020

Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes

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12 December 2020

IL-12 Acts Directly on DC to Promote Nuclear Localization of NF-κB and Primes DC for IL-12 Production

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12 December 2020

Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis

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12 December 2020

Dendritic cell lineage, plasticity and cross-regulation

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12 December 2020

Cutting edge: CD94/NKG2 is expressed on Th1 but not Th2 cells and costimulates Th1 effector functions

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12 December 2020

Strength of TCR signal determines the costimulatory requirements for Th1 and Th2 CD4+ T cell differentiation

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12 December 2020

Signaling and transcription in T helper development

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12 December 2020

Selective expression of an interleukin-12 receptor component by human T helper 1 cells

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12 December 2020