Antimalarial drug discovery: targeting protein kinases (Q36734919)

16 August 2017

1 reference

title

Antimalarial drug discovery: targeting protein kinases (English)

1 reference

16 August 2017

0 references

1 reference

Christian Doerig

1

0 references

Laurent Meijer

series ordinal

2

object named as

Laurent Meijer

1 reference

PubMed ID

17298288

16 August 2017

language of work or name

English

0 references

publication date

1 March 2007

1 reference

Expert Opinion on Therapeutic Targets

16 August 2017

1 reference

16 August 2017

11

1 reference

16 August 2017

3

1 reference

16 August 2017

279-290

1 reference

The economic and social burden of malaria

16 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.279

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.279

Medical need, scientific opportunity and the drive for antimalarial drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.279

Introduction. Antimalarial drug resistance: ramifications, explanations and challenges.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.279

Drug development for neglected diseases: a deficient market and a public-health policy failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.279

Human members of the eukaryotic protein kinase family

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.279

The protein kinase complement of the human genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.279

Protein kinase resource: an integrated environment for phosphorylation research

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.279

Protein kinases--the major drug targets of the twenty-first century?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.279

The design of drug candidate molecules as selective inhibitors of therapeutically relevant protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.279

The deep roots of eukaryotes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.279

An overview of Plasmodium protein kinases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.279

Protein kinases of the human malaria parasite Plasmodium falciparum: the kinome of a divergent eukaryote

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.279

Protein kinases as targets for anti-parasitic chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.279

Protein kinases as targets for antimalarial intervention: Kinomics, structure-based design, transmission-blockade, and targeting host cell enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.279

Mutants of Saccharomyces cerevisiae unresponsive to cell division control by polypeptide mating hormone

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.279

A new Apicomplexa-specific protein kinase family: multiple members in Plasmodium falciparum, all with an export signature

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.279

A novel protein kinase family in Plasmodium falciparum is differentially transcribed and secreted to various cellular compartments of the host cell

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.279

Comparative analysis of the kinomes of three pathogenic trypanosomatids: Leishmania major, Trypanosoma brucei and Trypanosoma cruzi

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.279

Calcium signaling through protein kinases. The Arabidopsis calcium-dependent protein kinase gene family.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.279

A MAP kinase homologue from the human malaria parasite, Plasmodium falciparum.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.279

An atypical mitogen-activated protein kinase (MAPK) homologue expressed in gametocytes of the human malaria parasite Plasmodium falciparum. Identification of a MAPK signature.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.279

PfPK7, an atypical MEK-related protein kinase, reflects the absence of classical three-component MAPK pathways in the human malaria parasite Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.279

Stage-specific expression of a Plasmodium falciparum protein related to the eukaryotic mitogen-activated protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.279

The role of two novel regulatory sites in the activation of the cGMP-dependent protein kinase from Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.279

Pfnek-1, a NIMA-related kinase from the human malaria parasite Plasmodium falciparum Biochemical properties and possible involvement in MAPK regulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.279

Gene targeting in malaria parasites

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.279

Pfmrk, a MO15-related protein kinase from Plasmodium falciparum. Gene cloning, sequence, stage-specific expression and chromosome localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.279

Targeting malaria with specific CDK inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.279

Rational inhibitor design and iterative screening in the identification of selective plasmodial cyclin dependent kinase inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.279

Antimalarial potential of xestoquinone, a protein kinase inhibitor isolated from a Vanuatu marine sponge Xestospongia sp.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.279

A mitogen-activated protein kinase regulates male gametogenesis and transmission of the malaria parasite Plasmodium berghei

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.279

An atypical mitogen-activated protein kinase controls cytokinesis and flagellar motility during male gamete formation in a malaria parasite

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.279

Sexual stage-specific expression of a third calcium-dependent protein kinase from Plasmodium falciparum.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.279

Plasmodium falciparum glycogen synthase kinase-3: molecular model, expression, intracellular localisation and selective inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.279

Isolation and expression of a gene specifying a cdc2-like protein kinase from the human malaria parasite Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.279

Cyclin-dependent kinase homologues of Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.279

PfPKB, a novel protein kinase B-like enzyme from Plasmodium falciparum: I. Identification, characterization, and possible role in parasite development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.279

The H89 cAMP-dependent protein kinase inhibitor blocks Plasmodium falciparum development in infected erythrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.279

PfPKB, a protein kinase B-like enzyme from Plasmodium falciparum: II. Identification of calcium/calmodulin as its upstream activator and dissection of a novel signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.279

Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.279

Atovaquone resistance in malaria parasites

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.279

A study of selected Plasmodium yoelii messenger RNAs during hepatocyte infection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.279

Magic bullets for protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.279

Calcium and a calcium-dependent protein kinase regulate gamete formation and mosquito transmission in a malaria parasite

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.279

Proteome analysis of separated male and female gametocytes reveals novel sex-specific Plasmodium biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.279

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.279

A calcium-dependent protein kinase regulates Plasmodium ookinete access to the midgut epithelial cell.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.279

Plasmodium berghei calcium-dependent protein kinase 3 is required for ookinete gliding motility and mosquito midgut invasion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.279

Protein kinases as drug targets in parasitic protozoa

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.279

Evaluation of kinase inhibitor selectivity by chemical proteomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.279

Kinase selectivity profiling by inhibitor affinity chromatography

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.279

The purinome, a complex mix of drug and toxicity targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.279

Roscovitine targets, protein kinases and pyridoxal kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.279

Structure-activity relationships and inhibitory effects of various purine derivatives on the in vitro growth of Plasmodium falciparum.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.279

Intracellular targets of cyclin-dependent kinase inhibitors: identification by affinity chromatography using immobilised inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.279

Purification and molecular characterization of cGMP-dependent protein kinase from Apicomplexan parasites. A novel chemotherapeutic target

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.279

A role for coccidian cGMP-dependent protein kinase in motility and invasion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.279

Toxoplasma gondii cyclic GMP-dependent kinase: chemotherapeutic targeting of an essential parasite protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.279

Cyclin-dependent protein kinases as therapeutic drug targets for antimalarial drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.279

Structures of P. falciparum PfPK5 test the CDK regulation paradigm and suggest mechanisms of small molecule inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.279

Secondary-structure matching (SSM), a new tool for fast protein structure alignment in three dimensions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.279

Crystal structure of the TAO2 kinase domain: activation and specificity of a Ste20p MAP3K

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.279

The use of anticancer drugs in antiparasitic chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.279

The liver stage of Plasmodium berghei inhibits host cell apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.279

Erythrocyte signal transduction pathways, their oxygenation dependence and functional significance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.279

Modulation of Ca2+-activated K+ channels of human erythrocytes by endogenous protein kinase C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.279

Differential effects of quercetin and resveratrol on Band 3 tyrosine phosphorylation signalling of red blood cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.279

Modulation of erythrocyte membrane mechanical function by protein 4.1 phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.279

Disruption of JNK2 decreases the cytokine response to Plasmodium falciparum glycosylphosphatidylinositol in vitro and confers protection in a cerebral malaria model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.279

Cdk2 knockout mice are viable

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.279

Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.279

21 January 2018

Biological revelations

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.279

A genomic perspective of protein kinases in Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.279

10.1517/14728222.11.3.279

21 January 2018

Identifiers

DOI

1 reference

16 August 2017

1 reference

PubMed ID

17298288