High throughput screening reveals several new classes of glutamate dehydrogenase inhibitors (Q36736887)

16 August 2017

High throughput screening reveals several new classes of glutamate dehydrogenase inhibitors (English)

1 reference

16 August 2017

Thomas J Smith

3

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author name string

Ming Li

series ordinal

1

1 reference

PMCID

2440342

16 August 2017

Aron Allen

series ordinal

2

1 reference

PMCID

2440342

16 August 2017

language of work or name

English

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publication date

29 November 2007

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16 August 2017

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16 August 2017

46

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16 August 2017

51

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16 August 2017

15089-15102

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Human rhinovirus capsid dynamics is controlled by canyon flexibility

16 August 2017

1 reference

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Structural studies on ADP activation of mammalian glutamate dehydrogenase and the evolution of regulation

29 September 2017

1 reference

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The structure of apo human glutamate dehydrogenase details subunit communication and allostery

29 September 2017

1 reference

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Antagonistic homotropic interactions as a possible explanation of coenzyme activation of glutamate dehydrogenase

29 September 2017

1 reference

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Hyperinsulinism/hyperammonemia syndrome in children with regulatory mutations in the inhibitory guanosine triphosphate-binding domain of glutamate dehydrogenase

29 September 2017

1 reference

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Structures of bovine glutamate dehydrogenase complexes elucidate the mechanism of purine regulation

29 September 2017

1 reference

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Protein-sensitive and fasting hypoglycemia in children with the hyperinsulinism/hyperammonemia syndrome.

29 September 2017

1 reference

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Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL

29 September 2017

1 reference

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In vivo detection of amyloid plaques in a mouse model of Alzheimer's disease

29 September 2017

1 reference

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The discovery of potent cRaf1 kinase inhibitors

29 September 2017

1 reference

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Antiviral agent blocks breathing of the common cold virus.

29 September 2017

1 reference

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Hyperinsulinism and hyperammonemia in infants with regulatory mutations of the glutamate dehydrogenase gene

29 September 2017

1 reference

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Aurintricarboxylic acid, a putative inhibitor of apoptosis, is a potent inhibitor of DNA topoisomerase II in vitro and in Chinese hamster fibrosarcoma cells

29 September 2017

1 reference

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The biochemistry and enzymology of amino acid dehydrogenases

29 September 2017

1 reference

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Mechanism of action of polymeric aurintricarboxylic acid, a potent inhibitor of protein-nucleic acid interactions

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1 reference

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Stimulation of pancreatic islet metabolism and insulin release by a nonmetabolizable amino acid

29 September 2017

1 reference

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Agonist activity of sumatriptan and metergoline at the human 5-HT1D beta receptor: further evidence for a role of the 5-HT1D receptor in the action of sumatriptan

29 September 2017

1 reference

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Use of aurintricarboxylic acid as an inhibitor of nucleases during nucleic acid isolation

29 September 2017

1 reference

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Formation of transient complexes in the glutamate dehydrogenase catalyzed reaction

29 September 2017

1 reference

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A signaling role of glutamine in insulin secretion

29 September 2017

1 reference

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The imidazoline derivative calmidazolium inhibits voltage-gated Ca(2+)-channels and insulin release but has no effect on the phospholipase C system in insulin producing RINm5F-cells

28 June 2018

1 reference

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Interpretation of binding curves obtained with high receptor concentrations: practical aid for computer analysis.

28 June 2018

1 reference

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L-leucine and a nonmetabolized analogue activate pancreatic islet glutamate dehydrogenase

28 June 2018

1 reference

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Identification of the lysine and tyrosine peptides labeled by 5'-p-fluorosulfonylbenzoyladenosine in the NADH inhibitory site of glutamate dehydrogenase

28 June 2018

1 reference

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Kinetic studies of glutamate dehydrogenase with glutamate and norvaline as substrates. Coenzyme activation and negative homotropic interactions in allosteric enzymes

28 June 2018

1 reference

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An investigation of functional similarities between the sarcoplasmic reticulum and platelet calcium-dependent adenosinetriphosphatases with the inhibitors quercetin and calmidazolium

28 June 2018

1 reference

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Negative co-operativity in glutamate dehydrogenase. Involvement of the 2-position in glutamate in the induction of conformational changes

28 June 2018

1 reference

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Green tea polyphenols modulate insulin secretion by inhibiting glutamate dehydrogenase

28 June 2018

1 reference

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Evolution of glutamate dehydrogenase regulation of insulin homeostasis is an example of molecular exaptation

5 September 2018

1 reference

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Amyloid imaging probes are useful for detection of prion plaques and treatment of transmissible spongiform encephalopathies.

5 September 2018

1 reference

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A screen for drugs that protect against the cytotoxicity of polyglutamine-expanded androgen receptor.

5 September 2018

1 reference

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Substrate inhibition of Pediococcus acidilactici by glucose on a waste medium. Simulations and experimental results

5 September 2018

1 reference

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Regulation of leucine-stimulated insulin secretion and glutamine metabolism in isolated rat islets

5 September 2018

1 reference

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Selectivity of 4,5,6,7-tetrabromobenzotriazole, an ATP site-directed inhibitor of protein kinase CK2 ('casein kinase-2').

5 September 2018

1 reference

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Mitochondrial glutamate acts as a messenger in glucose-induced insulin exocytosis.

5 September 2018

1 reference

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Inhibition by suloctidil of [3H] nitrendipine binding to cerebral cortex membranes

5 September 2018

1 reference

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Inhibition of Ca2+-dependent protein kinase and Ca2+/Mg2+-ATPase in cardiac sarcolemma by the anti-calmodulin drug calmidazolium.

5 September 2018

1 reference

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The Effects of Metergoline and Other Serotonin Receptor Antagonists on Serum Corticosterone in Rats

5 September 2018

1 reference

12 December 2020

Coenzyme binding to glutamate dehydrogenase. A study by relaxation kinetics

1 reference

12 December 2020

Ethaverine, a derivative of papaverine, inhibits cardiac L-type calcium channels

1 reference

12 December 2020

In vitro vasorelaxing activity of suloctidil

1 reference

12 December 2020

Lysine and tyrosine in the NADH inhibitory site of bovine liver glutamate dehydrogenase

1 reference

12 December 2020

Regulation of bovine glutamate dehydrogenase. The effects of pH and ADP

1 reference

12 December 2020

The influence of diethylstilbestrol and adenosine diphosphate on pyridine nucleotide coenzyme binding by glutamic dehydrogenase

1 reference

12 December 2020

Studies of glutamate dehydrogenase. The influence of ADP, GTP, and L-glutamate on the binding of the reduced coenzyme to beef-liver glutamate dehydrogenase

1 reference

12 December 2020

Halogenated benzimidazoles and benzotriazoles as selective inhibitors of protein kinases CK I and CK II from Saccharomyces cerevisiae and other sources

1 reference

12 December 2020

Molecular basis and characterization of the hyperinsulinism/hyperammonemia syndrome: predominance of mutations in exons 11 and 12 of the glutamate dehydrogenase gene. HI/HA Contributing Investigators

1 reference

12 December 2020

Regulation of insulin release by factors that also modify glutamate dehydrogenase

1 reference

12 December 2020

Glutamate is not a messenger in insulin secretion

1 reference

12 December 2020

A conformational transition of the oligomer of glutamate dehydrogenase induced by half-saturation with NAD + or NADP +

1 reference

12 December 2020

Identifiers

DOI

10.1021/BI7018783

1 reference

16 August 2017

1 reference

16 August 2017

1 reference

PMCID

2440342