Mithramycin analogues generated by combinatorial biosynthesis show improved bioactivity (Q36741739)

16 August 2017

Mithramycin analogues generated by combinatorial biosynthesis show improved bioactivity (English)

1 reference

16 August 2017

Streptomyces argillaceus

1 reference

Deoliosyl-3C-|A-L-digitoxosyl-MTM

1 reference

3A-deolivosyl-mithramycin

1 reference

Demycarosyl-3D-β-D-digitoxosyl-mithramycin

1 reference

Deoliosyl-3C-β-D-mycarosyl-mithramycin

1 reference

Alfredo F Braña

3

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Carmen Méndez

object named as

Carmen Méndez

7

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author name string

Irfan Baig

1

1 reference

16 August 2017

María Perez

2

1 reference

16 August 2017

Rohini Gomathinayagam

4

1 reference

16 August 2017

Chendil Damodaran

5

1 reference

16 August 2017

Jose A Salas

6

1 reference

16 August 2017

Jürgen Rohr

8

1 reference

16 August 2017

15 January 2008

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full work available at URL

16 August 2017

https://europepmc.org/articles/pmc2442402?pdf=render

1 reference

19 March 2024

https://api.unpaywall.org/v2/10.1021/np0705763?email=unpaywall_01@example.com

published in

Journal of Natural Products

1 reference

16 August 2017

71

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16 August 2017

2

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16 August 2017

199-207

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https://api.unpaywall.org/v2/10.1021/np0705763?email=unpaywall_01@example.com

16 August 2017

1 reference

19 March 2024

access restriction status

open access

1 reference

based on heuristic

inferred from online access status

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Inhibition of c-src transcription by mithramycin: structure-activity relationships of biosynthetically produced mithramycin analogues using the c-src promoter as target

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Mithramycin SK, A Novel Antitumor Drug with Improved Therapeutic Index, Mithramycin SA, and Demycarosyl-mithramycin SK: Three New Products Generated in the Mithramycin Producer Streptomyces argillaceus through Combinatorial Biosynthesis

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Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces argillaceus, reveal nov

29 September 2017

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The Structure of Mithramycin Reinvestigated

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Identification of two genes from Streptomyces argillaceus encoding glycosyltransferases involved in transfer of a disaccharide during biosynthesis of the antitumor drug mithramycin

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Oxidative cleavage of premithramycin B is one of the last steps in the biosynthesis of the antitumor drug mithramycin

29 September 2017

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Characterization of kinetics and products of the Baeyer-Villiger oxygenase MtmOIV, the key enzyme of the biosynthetic pathway toward the natural product anticancer drug mithramycin from Streptomyces argillaceus

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Elucidation of the glycosylation sequence of mithramycin biosynthesis: isolation of 3A-deolivosylpremithramycin B and its conversion to premithramycin B by glycosyltransferase MtmGII.

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PubMed

https://pubmed.ncbi.nlm.nih.gov/18197601

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identification of Two Genes from Streptomyces argillaceus Encoding Glycosyltransferases Involved in Transfer of a Disaccharide during Biosynthesis of the Antitumor Drug Mithramycin

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.1128/JB.180.18.4929-4937.1998

Identifiers

DOI

10.1021/NP0705763

1 reference

16 August 2017

1 reference

16 August 2017

PubMed publication ID

18197601

1 reference