Emerging roles of nuclear protein phosphatases (Q36743535)

16 August 2017

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title

Emerging roles of nuclear protein phosphatases (English)

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16 August 2017

Greg B G Moorhead

1

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16 August 2017

Laura Trinkle-Mulcahy

series ordinal

2

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16 August 2017

Annegret Ulke-Lemée

series ordinal

3

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16 August 2017

1 March 2007

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Nature Reviews Molecular Cell Biology

16 August 2017

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16 August 2017

8

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16 August 2017

3

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16 August 2017

234-244

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https://scigraph.springernature.com/pub.10.1038/nrm2126

16 August 2017

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Protein kinases--the major drug targets of the twenty-first century?

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Protein tyrosine phosphatases: from genes, to function, to disease

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The twentieth century struggle to decipher insulin signalling

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Determinants for Dephosphorylation of the RNA Polymerase II C-Terminal Domain by Scp1

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Inhibitors of protein kinases and phosphatases

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Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling

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Sensitized RNAi screen of human kinases and phosphatases identifies new regulators of apoptosis and chemoresistance.

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Genome-wide functional analysis of human cell-cycle regulators.

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Protein tyrosine phosphatases in the human genome

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The structure and regulation of myotubularin phosphatases

31 March 2020

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Eya protein phosphatase activity regulates Six1-Dach-Eya transcriptional effects in mammalian organogenesis

31 March 2020

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The transcription factor Eyes absent is a protein tyrosine phosphatase

31 March 2020

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A structural perspective of CTD function

31 March 2020

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Small CTD phosphatases function in silencing neuronal gene expression

31 March 2020

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A Novel RNA Polymerase II C-terminal Domain Phosphatase That Preferentially Dephosphorylates Serine 5

31 March 2020

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Isolation and characterization of an inhibitor-sensitive and a polycation-stimulated protein phosphatase from rat liver nuclei

31 March 2020

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Identification of high levels of protein phosphatase-1 in rat liver nuclei

31 March 2020

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Differential subcellular localization of protein phosphatase-1 alpha, gamma1, and delta isoforms during both interphase and mitosis in mammalian cells

31 March 2020

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Determinants of the nucleolar targeting of protein phosphatase-1.

31 March 2020

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Growth arrest and DNA damage-inducible protein GADD34 targets protein phosphatase 1 alpha to the endoplasmic reticulum and promotes dephosphorylation of the alpha subunit of eukaryotic translation initiation factor 2

31 March 2020

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Structural basis for the recognition of regulatory subunits by the catalytic subunit of protein phosphatase 1

31 March 2020

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Structural basis of protein phosphatase 1 regulation

31 March 2020

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Identification of protein-phosphatase-1-binding domains on the glycogen and myofibrillar targetting subunits

31 March 2020

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A protein phosphatase-1-binding motif identified by the panning of a random peptide display library

31 March 2020

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Degeneracy and function of the ubiquitous RVXF motif that mediates binding to protein phosphatase-1.

31 March 2020

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Structural analysis of the protein phosphatase 1 docking motif: molecular description of binding specificities identifies interacting proteins

31 March 2020

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Subunit structure and regulation of protein phosphatase-1 in rat liver nuclei

31 March 2020

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Proteomic characterization of protein phosphatase complexes of the mammalian nucleus

31 March 2020

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Repo-Man recruits PP1 gamma to chromatin and is essential for cell viability

31 March 2020

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PITK, a PP1 targeting subunit that modulates the phosphorylation of the transcriptional regulator hnRNP K

31 March 2020

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SIPP1, a novel pre-mRNA splicing factor and interactor of protein phosphatase-1

31 March 2020

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Scapinin, a putative protein phosphatase-1 regulatory subunit associated with the nuclear nonchromatin structure

31 March 2020

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Functional and quantitative proteomics using SILAC

31 March 2020

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Condensin and Repo-Man-PP1 co-operate in the regulation of chromosome architecture during mitosis

31 March 2020

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Structure of protein phosphatase 2A core enzyme bound to tumor-inducing toxins

31 March 2020

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Crystal structure of a protein phosphatase 2A heterotrimeric holoenzyme

31 March 2020

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Structure of the protein phosphatase 2A holoenzyme

31 March 2020

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TIP41 interacts with TAP42 and negatively regulates the TOR signaling pathway

31 March 2020

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A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity

31 March 2020

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Modulation of the enzymatic properties of protein phosphatase 2A catalytic subunit by the recombinant 65-kDa regulatory subunit PR65alpha

31 March 2020

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The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm

31 March 2020

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Cloning and characterization of B delta, a novel regulatory subunit of protein phosphatase 2A

31 March 2020

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PR48, a novel regulatory subunit of protein phosphatase 2A, interacts with Cdc6 and modulates DNA replication in human cells

31 March 2020

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Adenovirus E4orf4 protein interacts with both Balpha and B' subunits of protein phosphatase 2A, but E4orf4-induced apoptosis is mediated only by the interaction with Balpha

31 March 2020

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Localization of Saccharomyces cerevisiae protein phosphatase 2A subunits throughout mitotic cell cycle

31 March 2020

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The alpha4 regulatory subunit exerts opposing allosteric effects on protein phosphatases PP6 and PP2A.

31 March 2020

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Protein phosphatase 6 subunit with conserved Sit4-associated protein domain targets IkappaBepsilon

31 March 2020

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Molecular basis for TPR domain-mediated regulation of protein phosphatase 5.

31 March 2020

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Nuclear localization of protein phosphatase 5 is dependent on the carboxy-terminal region

31 March 2020

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Characterization of Saccharomyces cerevisiae protein Ser/Thr phosphatase T1 and comparison to its mammalian homolog PP5

31 March 2020

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Molecular cloning, expression, and characterization of a novel human serine/threonine protein phosphatase, PP7, that is homologous to Drosophila retinal degeneration C gene product (rdgC)

31 March 2020

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PP7 is a positive regulator of blue light signaling in Arabidopsis.

31 March 2020

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Plant PP2C phosphatases: emerging functions in stress signaling

31 March 2020

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Molecular cloning of PP2Ceta, a novel member of the protein phosphatase 2C family

31 March 2020

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The type 2C Ser/Thr phosphatase PP2Cgamma is a pre-mRNA splicing factor

31 March 2020

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Comprehensive proteomic analysis of the human spliceosome

31 March 2020

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Human PIR1 of the protein-tyrosine phosphatase superfamily has RNA 5'-triphosphatase and diphosphatase activities

31 March 2020

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Nuclear localization and cell cycle regulation of a murine protein tyrosine phosphatase

31 March 2020

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Identification and molecular characterization of BP75, a novel bromodomain-containing protein

31 March 2020

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Nuclear localization of non-receptor protein tyrosine phosphatase epsilon is regulated by its unique N-terminal domain

31 March 2020

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EGF-stimulation activates the nuclear localization signal of SHP-1.

31 March 2020

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Epidermal growth factor receptor and the adaptor protein p52Shc are specific substrates of T-cell protein tyrosine phosphatase

31 March 2020

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The stress response to ionizing radiation involoves c-Abl-dependent phosphorylation of SHPTP1.

31 March 2020

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Nuclear localization of the PEP protein tyrosine phosphatase

31 March 2020

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FCP1, the RAP74-interacting subunit of a human protein phosphatase that dephosphorylates the carboxyl-terminal domain of RNA polymerase IIO

31 March 2020

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Chronophin, a novel HAD-type serine protein phosphatase, regulates cofilin-dependent actin dynamics

31 March 2020

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PP1/PP2A phosphatases are required for the second step of Pre-mRNA splicing and target specific snRNP proteins

31 March 2020

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Signaling by protein phosphatases in the nucleus

31 March 2020

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Shugoshin collaborates with protein phosphatase 2A to protect cohesin

31 March 2020

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Protein phosphatase 2A protects centromeric sister chromatid cohesion during meiosis I.

31 March 2020

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PP2A is required for centromeric localization of Sgo1 and proper chromosome segregation

31 March 2020

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Mitotic phosphatases: no longer silent partners

31 March 2020

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Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner

31 March 2020

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p53-inducible wip1 phosphatase mediates a negative feedback regulation of p38 MAPK-p53 signaling in response to UV radiation

31 March 2020

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Protein phosphatase 2Calpha inhibits the human stress-responsive p38 and JNK MAPK pathways

31 March 2020

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The p53-induced oncogenic phosphatase PPM1D interacts with uracil DNA glycosylase and suppresses base excision repair

31 March 2020

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Substrate specificity of the human protein phosphatase 2Cdelta, Wip1

31 March 2020

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PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints

31 March 2020

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A novel domain in the protein kinase SOS2 mediates interaction with the protein phosphatase 2C ABI2

31 March 2020

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Intrinsic kinase activity and SQ/TQ domain of Chk2 kinase as well as N-terminal domain of Wip1 phosphatase are required for regulation of Chk2 by Wip1.

31 March 2020

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PP2C phosphatases Ptc2 and Ptc3 are required for DNA checkpoint inactivation after a double-strand break

31 March 2020

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Wip1 Phosphatase Modulates ATM-Dependent Signaling Pathways

31 March 2020

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Autophosphorylation of ataxia-telangiectasia mutated is regulated by protein phosphatase 2A.

31 March 2020

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A phosphatase complex that dephosphorylates gammaH2AX regulates DNA damage checkpoint recovery

31 March 2020

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gamma-H2AX dephosphorylation by protein phosphatase 2A facilitates DNA double-strand break repair

31 March 2020

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Protein phosphatases regulate DNA-dependent protein kinase activity

31 March 2020

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Ser/Thr-specific protein phosphatases are required for both catalytic steps of pre-mRNA splicing

31 March 2020

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The protein phosphatase-1 regulator NIPP1 is also a splicing factor involved in a late step of spliceosome assembly

31 March 2020

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Interaction of protein phosphatase type 1 with a splicing factor.

31 March 2020

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Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry

31 March 2020

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Opposing effects of Ctk1 kinase and Fcp1 phosphatase at Ser 2 of the RNA polymerase II C-terminal domain

31 March 2020

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Interaction of Fcp1 phosphatase with elongating RNA polymerase II holoenzyme, enzymatic mechanism of action, and genetic interaction with elongator

31 March 2020

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Smad transcription factors

31 March 2020

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PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling

31 March 2020

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Small C-terminal domain phosphatases dephosphorylate the regulatory linker regions of Smad2 and Smad3 to enhance transforming growth factor-beta signaling

31 March 2020

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PP1 binds Sara and negatively regulates Dpp signaling in Drosophila melanogaster

31 March 2020

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Dephosphorylation of the linker regions of Smad1 and Smad2/3 by small C-terminal domain phosphatases has distinct outcomes for bone morphogenetic protein and transforming growth factor-beta pathways.

31 March 2020

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Identification of phosphatases for Smad in the BMP/DPP pathway

31 March 2020

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Unique players in the BMP pathway: small C-terminal domain phosphatases dephosphorylate Smad1 to attenuate BMP signaling.

31 March 2020

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Protein serine/threonine phosphatase PPM1A dephosphorylates Smad1 in the bone morphogenetic protein signaling pathway

31 March 2020

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Stable isotope labeling by amino acids in cell culture, SILAC, as a simple and accurate approach to expression proteomics

31 March 2020

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The protein kinase complement of the human genome

31 March 2020

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A genomic perspective on protein tyrosine phosphatases: gene structure, pseudogenes, and genetic disease linkage

31 March 2020

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Calcineurin binds the transcription factor NFAT1 and reversibly regulates its activity

31 March 2020

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Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene

31 March 2020

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Cofilin phosphatases and regulation of actin dynamics

31 March 2020

1 reference

Myotubularin phosphatases: policing 3-phosphoinositides

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRM2126

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Dimensions Publication ID

16 August 2017

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