Autophagy and neurodegeneration: when the cleaning crew goes on strike (Q36760662)

16 August 2017

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title

Autophagy and neurodegeneration: when the cleaning crew goes on strike (English)

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16 August 2017

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2

Ana Maria Cuervo

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Marta Martinez-vicente

object named as

Marta Martinez-Vicente

series ordinal

1

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publication date

1 April 2007

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16 August 2017

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16 August 2017

6

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16 August 2017

4

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16 August 2017

352-361

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16 August 2017

Functions of lysosomes

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

The molecular machinery of autophagy: unanswered questions

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

The pleiotropic role of autophagy: from protein metabolism to bactericide.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

Development by self-digestion: molecular mechanisms and biological functions of autophagy

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

Molecular dissection of autophagy: two ubiquitin-like systems

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

A Unified Nomenclature for Yeast Autophagy-Related Genes

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

Loss of autophagy in the central nervous system causes neurodegeneration in mice

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

Autophagy: in sickness and in health

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

Autophagy in health and disease: a double-edged sword

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

Autophagy in innate and adaptive immunity.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

Cellular autophagy: surrender, avoidance and subversion by microorganisms

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

Autophagic vacuolar myopathies

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

Sera from patients with type 2 diabetes and neuropathy induce autophagy and colocalization with mitochondria in SY5Y cells

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

Autophagy and its possible roles in nervous system diseases, damage and repair

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

Uptake--microautophagy--and degradation of exogenous proteins by isolated rat liver lysosomes. Effects of pH, ATP, and inhibitors of proteolysis

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

The TOR and EGO protein complexes orchestrate microautophagy in yeast

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

Peroxisome turnover by micropexophagy: an autophagy-related process

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

Peptide sequences that target cytosolic proteins for lysosomal proteolysis

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

Mechanisms of chaperone-mediated autophagy

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

Chaperone-mediated autophagy in aging and disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

A receptor for the selective uptake and degradation of proteins by lysosomes

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

Activation of chaperone-mediated autophagy during oxidative stress

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

Direct lysosomal uptake of alpha 2-microglobulin contributes to chemically induced nephropathy

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

Suppression of chaperone-mediated autophagy in the renal cortex during acute diabetes mellitus

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

Protein folding, misfolding, and aggregation. Formation of inclusion bodies and aggresomes.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

Cooperation of molecular chaperones with the ubiquitin/proteasome system

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

Protein degradation and protection against misfolded or damaged proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

Protein quality control: chaperones culling corrupt conformations

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

To be or not to be toxic: aggregations in Huntington and Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

Protein aggregation as a cause for disease.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

Paradoxical aggregation versus oligomerisation properties of mutant and wild-type huntingtin fragments

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

Autophagy in neurons: it is not all about food

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

Global impairment of the ubiquitin-proteasome system by nuclear or cytoplasmic protein aggregates precedes inclusion body formation.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

Consequences of the selective blockage of chaperone-mediated autophagy

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

HDAC6 and microtubules are required for autophagic degradation of aggregated huntingtin

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

Pathology and biology of the Lewy body

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

Genetics of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

Expanding insights of mitochondrial dysfunction in Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

Ubiquitin-proteasome system and Parkinson's diseases

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

alpha-Synuclein locus triplication causes Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

Interactions among alpha-synuclein, dopamine, and biomembranes: some clues for understanding neurodegeneration in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

Reversible inhibition of alpha-synuclein fibrillization by dopaminochrome-mediated conformational alterations.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

Subcellular localization of wild-type and Parkinson's disease-associated mutant alpha -synuclein in human and transgenic mouse brain

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

Neurodegenerative disease: amyloid pores from pathogenic mutations.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

α-Synuclein Is Degraded by Both Autophagy and the Proteasome

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

Expression of A53T mutant but not wild-type alpha-synuclein in PC12 cells induces alterations of the ubiquitin-dependent degradation system, loss of dopamine release, and autophagic cell death.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

Involvement of macroautophagy in the dissolution of neuronal inclusions.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

Role of oxidative damage in protein aggregation associated with Parkinson's disease and related disorders.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

Protein degradation and aging

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

DJ-1 is an indicator for endogenous reactive oxygen species elicited by endotoxin

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

Hereditary early-onset Parkinson's disease caused by mutations in PINK1

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

Impairment of the ubiquitin-proteasome system causes dopaminergic cell death and inclusion body formation in ventral mesencephalic cultures

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

Familial Alzheimer disease-linked presenilin 1 variants enhance production of both Abeta 1-40 and Abeta 1-42 peptides that are only partially sensitive to a potent aspartyl protease transition state inhibitor of "gamma-secretase".

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

Common structure and toxic function of amyloid oligomers implies a common mechanism of pathogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

Amyloid peptide attenuates the proteasome activity in neuronal cells

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

Peripheral proteasome and caspase activity in Parkinson disease and Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

Gene expression and cellular content of cathepsin D in Alzheimer's disease brain: evidence for early up-regulation of the endosomal-lysosomal system.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

Macroautophagy--a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

Bcl-2 inhibition of autophagy: a new route to cancer?

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

Huntingtin and the molecular pathogenesis of Huntington's disease. Fourth in molecular medicine review series

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

Structure and expression of the Huntington's disease gene: evidence against simple inactivation due to an expanded CAG repeat

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

Huntingtin expression stimulates endosomal-lysosomal activity, endosome tubulation, and autophagy.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

Huntingtin-protein interactions and the pathogenesis of Huntington's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

Transcriptional dysregulation in Huntington's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

Progressive disruption of cellular protein folding in models of polyglutamine diseases.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

Aggresomes protect cells by enhancing the degradation of toxic polyglutamine-containing protein

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

Absence of behavioral abnormalities and neurodegeneration in vivo despite widespread neuronal huntingtin inclusions

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

Molecular chaperones as modulators of polyglutamine protein aggregation and toxicity

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

Inhibition of 26S proteasome activity by huntingtin filaments but not inclusion bodies isolated from mouse and human brain

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

Autophagy regulates the processing of amino terminal huntingtin fragments

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

TOR, a central controller of cell growth

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

Autophagy and aging: the importance of maintaining "clean" cells

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

Protein degradation in the aging organism.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

Altered proteasome structure, function, and oxidation in aged muscle

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

The role of macroautophagy in the ageing process, anti-ageing intervention and age-associated diseases

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

The effect of age on formation and elimination of autophagic vacuoles in mouse hepatocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

Altered dynamics of the lysosomal receptor for chaperone-mediated autophagy with age.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

Rapamycin alleviates toxicity of different aggregate-prone proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

Dynein mutations impair autophagic clearance of aggregate-prone proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

Lithium induces autophagy by inhibiting inositol monophosphatase

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

Anti-aging effects of anti-lipolytic drugs

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

The anti-ageing effects of caloric restriction may involve stimulation of macroautophagy and lysosomal degradation, and can be intensified pharmacologically

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970076-5

7 January 2021

10.1016/S1474-4422(07)70076-5

Identifiers

DOI

1 reference

16 August 2017

1 reference

PubMed ID

17362839