Huntingtin expression stimulates endosomal-lysosomal activity, endosome tubulation, and autophagy. (Q45301281)

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31 October 2019

title

Huntingtin expression stimulates endosomal-lysosomal activity, endosome tubulation, and autophagy (English)

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31 October 2019

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K B Kegel

1

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31 October 2019

M Kim

2

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31 October 2019

E Sapp

3

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31 October 2019

C McIntyre

4

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31 October 2019

J G Castaño

5

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31 October 2019

N Aronin

6

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31 October 2019

M DiFiglia

7

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31 October 2019

language of work or name

English

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publication date

1 October 2000

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31 October 2019

published in

Journal of Neuroscience

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31 October 2019

volume

20

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31 October 2019

issue

19

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31 October 2019

page(s)

7268-7278

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Huntingtin localization in brains of normal and Huntington's disease patients

31 October 2019

cites work

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Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

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Huntingtin interacts with a family of WW domain proteins

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The mouse SKD1, a homologue of yeast Vps4p, is required for normal endosomal trafficking and morphology in mammalian cells

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Nuclear targeting of mutant Huntingtin increases toxicity

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Products of endocytosis and autophagy are retrieved from axons by regulated retrograde organelle transport

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Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

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Interaction of huntingtin-associated protein with dynactin P150Glued

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Brefeldin A's effects on endosomes, lysosomes, and the TGN suggest a general mechanism for regulating organelle structure and membrane traffic

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12 December 2020

A huntingtin-associated protein enriched in brain with implications for pathology

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12 December 2020

The cellular and subcellular localization of huntingtin-associated protein 1 (HAP1): comparison with huntingtin in rat and human.

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12 December 2020

Requirement for hsp70 in the mitochondrial matrix for translocation and folding of precursor proteins

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12 December 2020

The influence of huntingtin protein size on nuclear localization and cellular toxicity.

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12 December 2020

Activation of caspase-3-like protease by digitonin-treated lysosomes

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12 December 2020

Immunohistochemical distribution and electron microscopic subcellular localization of the proteasome in the rat CNS.

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12 December 2020

Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons

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12 December 2020

CAG expansion affects the expression of mutant Huntingtin in the Huntington's disease brain

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12 December 2020

Properties of the endosomal-lysosomal system in the human central nervous system: disturbances mark most neurons in populations at risk to degenerate in Alzheimer's disease.

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Loss of endosomal/lysosomal membrane impermeability is an early event in amyloid Abeta1-42 pathogenesis

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Characterization of a cis-Golgi matrix protein, GM130

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Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease.

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Autophagy is activated by apoptotic signalling in sympathetic neurons: an alternative mechanism of death execution

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Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract

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Induction of autophagy and inhibition of tumorigenesis by beclin 1

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12 December 2020

Forskolin and dopamine D1 receptor activation increase huntingtin's association with endosomes in immortalized neuronal cells of striatal origin.

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12 December 2020

Chaperone suppression of aggregation and altered subcellular proteasome localization imply protein misfolding in SCA1.

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12 December 2020

SH3GL3 associates with the Huntingtin exon 1 protein and promotes the formation of polygln-containing protein aggregates

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12 December 2020

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12 December 2020

Immortalized murine striatal neuronal cell lines expressing dopamine receptors and cholinergic properties

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12 December 2020

Analysis of the role of heat shock protein (Hsp) molecular chaperones in polyglutamine disease

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12 December 2020

VPS21 controls entry of endocytosed and biosynthetic proteins into the yeast prevacuolar compartment.

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12 December 2020

Neuronal autophagy in experimental scrapie

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12 December 2020

Supervising the fold: functional principles of molecular chaperones

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12 December 2020

Guanine nucleotides modulate the effects of brefeldin A in semipermeable cells: regulation of the association of a 110-kD peripheral membrane protein with the Golgi apparatus

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12 December 2020

Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

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12 December 2020

A role for calmodulin in organelle membrane tubulation

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12 December 2020

HIP1, a human homologue of S. cerevisiae Sla2p, interacts with membrane-associated huntingtin in the brain

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12 December 2020

Analysis of Huntingtin-associated protein 1 in mouse brain and immortalized striatal neurons

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12 December 2020

Studies on the mechanisms of autophagy: formation of the autophagic vacuole

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12 December 2020

Purkinje cell expression of a mutant allele of SCA1 in transgenic mice leads to disparate effects on motor behaviors, followed by a progressive cerebellar dysfunction and histological alterations.

1 reference

12 December 2020

10.1523/JNEUROSCI.20-19-07268.2000

Identifiers

DOI

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31 October 2019

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31 October 2019

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