Update on pathophysiology of scleroderma with special reference to immunoinflammatory events (Q36761364)

16 August 2017

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title

Update on pathophysiology of scleroderma with special reference to immunoinflammatory events (English)

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16 August 2017

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Carlo Chizzolini

1

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PubMed ID

17364450

16 August 2017

language of work or name

English

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publication date

1 January 2007

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16 August 2017

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16 August 2017

39

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16 August 2017

1

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16 August 2017

42-53

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Preliminary criteria for the classification of systemic sclerosis (scleroderma)

16 August 2017

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https://api.crossref.org/works/10.1080%2F07853890601098152

Scleroderma-like cutaneous syndromes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890601098152

Nephrogenic fibrosing dermopathy: the first 6 years

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890601098152

Scleroderma: from cell and molecular mechanisms to disease models

21 January 2018

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https://api.crossref.org/works/10.1080%2F07853890601098152

Targeted therapy comes of age in scleroderma

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890601098152

Following the molecular pathways toward an understanding of the pathogenesis of systemic sclerosis

21 January 2018

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https://api.crossref.org/works/10.1080%2F07853890601098152

Is systemic sclerosis an antigen-driven T cell disease?

21 January 2018

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https://api.crossref.org/works/10.1080%2F07853890601098152

Recent advances in fibroblast signaling and biology in scleroderma

21 January 2018

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https://api.crossref.org/works/10.1080%2F07853890601098152

Altered B lymphocyte function induces systemic autoimmunity in systemic sclerosis

21 January 2018

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https://api.crossref.org/works/10.1080%2F07853890601098152

Retroviruses and the pathogenesis of systemic sclerosis.

21 January 2018

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https://api.crossref.org/works/10.1080%2F07853890601098152

Human cytomegalovirus and the vasculopathies of autoimmune diseases (especially scleroderma), allograft rejection, and coronary restenosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890601098152

Antibodies against human cytomegalovirus in the pathogenesis of systemic sclerosis: a gene array approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890601098152

Systemic sclerosis immunoglobulin G autoantibodies bind the human cytomegalovirus late protein UL94 and induce apoptosis in human endothelial cells.

21 January 2018

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https://api.crossref.org/works/10.1080%2F07853890601098152

Systemic sclerosis and occupational risk factors: a case-control study

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890601098152

Scleroderma and solvent exposure among women

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890601098152

Association of fibrillin 1 single-nucleotide polymorphism haplotypes with systemic sclerosis in Choctaw and Japanese populations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890601098152

Identification of novel targets in scleroderma: update on population studies, cDNA arrays, SNP analysis, and mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890601098152

Association of functional microsatellites in the human type I collagen alpha2 chain (COL1A2) gene with systemic sclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890601098152

The genetics of systemic sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890601098152

Oxidative stress in scleroderma: maintenance of scleroderma fibroblast phenotype by the constitutive up-regulation of reactive oxygen species generation through the NADPH oxidase complex pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890601098152

Uncontrolled expression of vascular endothelial growth factor and its receptors leads to insufficient skin angiogenesis in patients with systemic sclerosis

21 January 2018

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https://api.crossref.org/works/10.1080%2F07853890601098152

Raynaud phenomenon and the vascular disease in scleroderma

21 January 2018

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https://api.crossref.org/works/10.1080%2F07853890601098152

Endothelial cell apoptosis in systemic sclerosis is induced by antibody-dependent cell-mediated cytotoxicity via CD95.

21 January 2018

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https://api.crossref.org/works/10.1080%2F07853890601098152

Pathogenesis of fibrosis: type 1 collagen and the skin

21 January 2018

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https://api.crossref.org/works/10.1080%2F07853890601098152

21 January 2018

Cutaneous wound healing

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https://api.crossref.org/works/10.1080%2F07853890601098152

Matrix metalloproteinases

21 January 2018

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https://api.crossref.org/works/10.1080%2F07853890601098152

Matrix metalloproteinase degradation of extracellular matrix: biological consequences

21 January 2018

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https://api.crossref.org/works/10.1080%2F07853890601098152

Fibroblast matrix gene expression and connective tissue remodeling: role of endothelin-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890601098152

Significant correlation between connective tissue growth factor gene expression and skin sclerosis in tissue sections from patients with systemic sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890601098152

Inhibition of type I collagen production by dermal fibroblasts upon contact with activated T cells: different sensitivity to inhibition between systemic sclerosis and control fibroblasts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890601098152

Systemic sclerosis Th2 cells inhibit collagen production by dermal fibroblasts via membrane-associated tumor necrosis factor alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890601098152

Scleroderma and Smads: dysfunctional Smad family dynamics culminating in fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890601098152

Impaired Smad7-Smurf-mediated negative regulation of TGF-beta signaling in scleroderma fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890601098152

Selective inhibition of activin receptor-like kinase 5 signaling blocks profibrotic transforming growth factor beta responses in skin fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890601098152

An increased transforming growth factor beta receptor type I:type II ratio contributes to elevated collagen protein synthesis that is resistant to inhibition via a kinase-deficient transforming growth factor beta receptor type II in scleroderma

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890601098152

Constitutive thrombospondin-1 overexpression contributes to autocrine transforming growth factor-beta signaling in cultured scleroderma fibroblasts

21 January 2018

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https://api.crossref.org/works/10.1080%2F07853890601098152

Systemic and cell type-specific gene expression patterns in scleroderma skin

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890601098152

Cytokine modulation of extracellular matrix gene expression: relevance to fibrotic skin diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890601098152

Transforming growth factor-beta and connective tissue growth factor: key cytokines in scleroderma pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890601098152

Pathogenesis of fibrosis: role of TGF-beta and CTGF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890601098152

TGF-beta-induced SMAD signaling and gene regulation: consequences for extracellular matrix remodeling and wound healing

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890601098152

TGF-beta signaling and the fibrotic response

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890601098152

Insights into the molecular mechanism of chronic fibrosis: the role of connective tissue growth factor in scleroderma

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890601098152

Endogenous IL-1alpha from systemic sclerosis fibroblasts induces IL-6 and PDGF-A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890601098152

TGF-beta and TNF-alpha: antagonistic cytokines controlling type I collagen gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890601098152

Tumor necrosis factor/cachectin plays a key role in bleomycin-induced pneumopathy and fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890601098152

Inhibition of excessive scleroderma fibroblast collagen production by recombinant gamma-interferon. Association with a coordinate decrease in types I and III procollagen messenger RNA levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890601098152

Human fibroblasts synthesize elevated levels of extracellular matrix proteins in response to interleukin 4

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890601098152

Fibrotic disease and the T(H)1/T(H)2 paradigm

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890601098152

Lack of skin fibrosis in tight skin (TSK) mice with targeted mutation in the interleukin-4R alpha and transforming growth factor-beta genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890601098152

Disrupting the IL-4 gene rescues mice homozygous for the tight-skin mutation from embryonic death and diminishes TGF-beta production by fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890601098152

Interleukin-13 induces tissue fibrosis by selectively stimulating and activating transforming growth factor beta(1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890601098152

IL-13 signaling through the IL-13alpha2 receptor is involved in induction of TGF-beta1 production and fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890601098152

Chemokines and leukocyte traffic

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890601098152

Cellular infiltrates in scleroderma skin

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890601098152

Functional and phenotypic analysis of T lymphocytes cloned from the skin of patients with systemic sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890601098152

Autoantibodies to fibrillin-1 activate normal human fibroblasts in culture through the TGF-beta pathway to recapitulate the "scleroderma phenotype".

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890601098152

CD19 regulates Src family protein tyrosine kinase activation in B lymphocytes through processive amplification

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890601098152

Digital ulcers in systemic sclerosis: prevention by treatment with bosentan, an oral endothelin receptor antagonist.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890601098152

Systemic sclerosis associated pulmonary hypertension: improved survival in the current era.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890601098152

Cyclophosphamide versus placebo in scleroderma lung disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890601098152

Autologous stem cell transplantation in the treatment of systemic sclerosis: report from the EBMT/EULAR Registry

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890601098152

Systemic sclerosis in Europe: first report from the EULAR Scleroderma Trials And Research (EUSTAR) group database

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890601098152

10.1080/07853890601098152

21 January 2018

Identifiers

DOI

1 reference

16 August 2017

1 reference

PubMed ID

17364450