Stochasticity and spatial heterogeneity in T-cell activation (Q36762518)

16 August 2017

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title

Stochasticity and spatial heterogeneity in T-cell activation (English)

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Philip Anton van der Merwe

16 August 2017

series ordinal

2

object named as

P Anton van der Merwe

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16 August 2017

1

Nigel J Burroughs

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16 August 2017

1 April 2007

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16 August 2017

Immunological Reviews

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16 August 2017

216

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16 August 2017

69-80

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Recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation

16 August 2017

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2006.00486.X

T cell receptor engagement by peptide-MHC ligands induces a conformational change in the CD3 complex of thymocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2006.00486.X

The CD3epsilon proline-rich sequence, and its interaction with Nck, is not required for T cell development and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2006.00486.X

A TCR binds to antagonist ligands with lower affinities and faster dissociation rates than to agonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2006.00486.X

Serial triggering of many T-cell receptors by a few peptide-MHC complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2006.00486.X

Cytoskeletal polarization and redistribution of cell-surface molecules during T cell antigen recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2006.00486.X

The immunological synapse.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2006.00486.X

Direct observation of ligand recognition by T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2006.00486.X

T cell killing does not require the formation of a stable mature immunological synapse.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2006.00486.X

T-cell activation: A queuing theory analysis at low agonist density

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2006.00486.X

The T-cell receptor signalosome: a dynamic structure with expanding complexity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2006.00486.X

Kinetic proofreading in T-cell receptor signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2006.00486.X

Kinetic discrimination in T-cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2006.00486.X

Antigen presentation in extracellular matrix: interactions of T cells with dendritic cells are dynamic, short lived, and sequential

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2006.00486.X

Single cell analysis reveals regulated hierarchical T cell antigen receptor signaling thresholds and intraclonal heterogeneity for individual cytokine responses of CD4+ T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2006.00486.X

Different responses are elicited in cytotoxic T lymphocytes by different levels of T cell receptor occupancy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2006.00486.X

Dynamic polarization of the microtubule cytoskeleton during CTL-mediated killing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2006.00486.X

Continuous T cell receptor signaling required for synapse maintenance and full effector potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2006.00486.X

The duration of antigenic stimulation determines the fate of naive and effector T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2006.00486.X

Immunological synapses are versatile structures enabling selective T cell polarization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2006.00486.X

Dynamic tuning of T cell reactivity by self-peptide-major histocompatibility complex ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2006.00486.X

CD8 T cell sensory adaptation dependent on TCR avidity for self-antigens.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2006.00486.X

Ultrasensitivity in the mitogen-activated protein kinase cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2006.00486.X

The IkappaB-NF-kappaB signaling module: temporal control and selective gene activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2006.00486.X

Agonist/endogenous peptide-MHC heterodimers drive T cell activation and sensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2006.00486.X

Initiation of TCR signalling revisited

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2006.00486.X

CD45 ectodomain controls interaction with GEMs and Lck activity for optimal TCR signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2006.00486.X

The tyrosine phosphatase CD148 is excluded from the immunologic synapse and down-regulates prolonged T cell signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2006.00486.X

Actin and agonist MHC-peptide complex-dependent T cell receptor microclusters as scaffolds for signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2006.00486.X

Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2006.00486.X

T cell receptor ligation induces the formation of dynamically regulated signaling assemblies

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2006.00486.X

Ligand detection and discrimination by spatial relocalization: A kinase-phosphatase segregation model of TCR activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2006.00486.X

The structure and ligand interactions of CD2: implications for T-cell function

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2006.00486.X

Evidence that structural rearrangements and/or flexibility during TCR binding can contribute to T cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2006.00486.X

Differential segregation in a cell-cell contact interface: the dynamics of the immunological synapse

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2006.00486.X

Equilibrium thermodynamics of cell-cell adhesion mediated by multiple ligand-receptor pairs

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2006.00486.X

The kinetic-segregation model: TCR triggering and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2006.00486.X

10.1111/J.1600-065X.2006.00486.X

21 January 2018

Identifiers

DOI

1 reference

16 August 2017

1 reference

PubMed ID

17367335