Hypoxia-inducible factor prolyl-hydroxylase-2 mediates transforming growth factor beta 1-induced epithelial-mesenchymal transition in renal tubular cells. (Q36780416)

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scientific article published on March 2013

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English	Hypoxia-inducible factor prolyl-hydroxylase-2 mediates transforming growth factor beta 1-induced epithelial-mesenchymal transition in renal tubular cells.	scientific article published on March 2013

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25 February 2020

Hypoxia-inducible factor prolyl-hydroxylase-2 mediates transforming growth factor beta 1-induced epithelial-mesenchymal transition in renal tubular cells (English)

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25 February 2020

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25 February 2020

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Qing Zhu

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Junping Hu

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Pin-Lan Li

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Fan Zhang

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Ningjun Li

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1 March 2013

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25 February 2020

Biochimica et Biophysica Acta

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1454-1462

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25 February 2020

Overexpression of HIF prolyl-hydoxylase-2 transgene in the renal medulla induced a salt sensitive hypertension

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Erbin inhibits TGF-β1-induced EMT in renal tubular epithelial cells through an ERK-dependent pathway

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Cellular and molecular mechanisms of renal fibrosis

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Silencing of hypoxia-inducible factor-1α gene attenuated angiotensin II-induced renal injury in Sprague-Dawley rats

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The role of EMT in renal fibrosis

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The role of TGF-β and epithelial-to mesenchymal transition in diabetic nephropathy.

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Interdependence of HIF-1α and TGF-β/Smad3 signaling in normoxic and hypoxic renal epithelial cell collagen expression

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IKK(α) controls canonical TGF(ß)-SMAD signaling to regulate genes expressing SNAIL and SLUG during EMT in panc1 cells

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Opposite functions of HIF-α isoforms in VEGF induction by TGF-β1 under non-hypoxic conditions

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29 September 2017

Hypoxia-inducible factor-1α contributes to the profibrotic action of angiotensin II in renal medullary interstitial cells

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Transforming growth factor-{beta}1 induces Smad3-dependent {beta}1 integrin gene expression in epithelial-to-mesenchymal transition during chronic tubulointerstitial fibrosis

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29 September 2017

Hypoxia-inducible factor prolyl-hydroxylase 2 senses high-salt intake to increase hypoxia inducible factor 1alpha levels in the renal medulla

1 reference

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29 September 2017

Hypoxia stimulates hepatocyte epithelial to mesenchymal transition by hypoxia-inducible factor and transforming growth factor-beta-dependent mechanisms

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TGF-beta1-induced epithelial-to-mesenchymal transition and therapeutic intervention in diabetic nephropathy.

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Hypoxia-induced alveolar epithelial-mesenchymal transition requires mitochondrial ROS and hypoxia-inducible factor 1.

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The basics of epithelial-mesenchymal transition

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29 September 2017

Non-hypoxic activation of the negative regulatory feedback loop of prolyl-hydroxylase oxygen sensors

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HIF-prolyl hydroxylases in the rat kidney: physiologic expression patterns and regulation in acute kidney injury

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TGF-beta-induced epithelial to mesenchymal transition

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C-peptide reverses TGF-beta1-induced changes in renal proximal tubular cells: implications for treatment of diabetic nephropathy

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29 September 2017

Activation of the renin-angiotensin system and chronic hypoxia of the kidney

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29 September 2017

Diabetic nephropathy: mechanisms of renal disease progression

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Regulation of adult erythropoiesis by prolyl hydroxylase domain proteins

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29 September 2017

Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition

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29 September 2017

Connective tissue growth factor plays an important role in advanced glycation end product-induced tubular epithelial-to-mesenchymal transition: implications for diabetic renal disease.

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Transforming growth factor beta1 induces hypoxia-inducible factor-1 stabilization through selective inhibition of PHD2 expression.

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A family with erythrocytosis establishes a role for prolyl hydroxylase domain protein 2 in oxygen homeostasis

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5 September 2018

Activation of hypoxia-inducible factors ameliorates hypoxic distal tubular injury in the isolated perfused rat kidney

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5 September 2018

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5 September 2018

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12 December 2020

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Resolved: EMT produces fibroblasts in the kidney

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https://pubmed.ncbi.nlm.nih.gov/23466866

12 December 2020

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Mechanisms of tubulointerstitial fibrosis

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12 December 2020

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Hypoxia-inducible factor-1α mediates TGF-β-induced PAI-1 production in alveolar macrophages in pulmonary fibrosis

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12 December 2020

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10.1016/J.BBAMCR.2013.02.029

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25 February 2020

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25 February 2020

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25 February 2020

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