Structure and function of sodium-coupled GABA and glutamate transporters (Q36785016)

16 August 2017

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title

Structure and function of sodium-coupled GABA and glutamate transporters (English)

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16 August 2017

Baruch I Kanner

1

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16 August 2017

1 January 2006

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16 August 2017

12

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Journal of Membrane Biology

inferred from page(s)

published in

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16 August 2017

213

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2

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16 August 2017

89-100

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https://scigraph.springernature.com/pub.10.1007/s00232-006-0877-5

16 August 2017

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cites work

Bioenergetics of neurotransmitter transport

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Crossref

https://api.crossref.org/works/10.1007%2FS00232-006-0877-5

Electrogenic uptake of gamma-aminobutyric acid by a cloned transporter expressed in Xenopus oocytes

21 January 2018

1 reference

12 December 2020

Multiple consequences of mutating two conserved beta-bridge forming residues in the translocation cycle of a neuronal glutamate transporter

1 reference

12 December 2020

The interaction of the gamma-aminobutyric acid transporter GAT-1 with the neurotransmitter is selectively impaired by sulfhydryl modification of a conformationally sensitive cysteine residue engineered into extracellular loop IV

1 reference

12 December 2020

The aqueous accessibility in the external half of transmembrane domain I of the GABA transporter GAT-1 Is modulated by its ligands

1 reference

12 December 2020

The substrates of a sodium- and chloride-coupled gamma-aminobutyric acid transporter protect multiple sites throughout the protein against proteolytic cleavage.

1 reference

12 December 2020

Dynamic equilibrium between coupled and uncoupled modes of a neuronal glutamate transporter

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12 December 2020

Flux coupling in a neuronal glutamate transporter

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12 December 2020

Efflux of L-glutamate by synaptic plasma membrane vesicles isolated from rat brain.

1 reference

12 December 2020

The dual-function glutamate transporters: structure and molecular characterisation of the substrate-binding sites

1 reference

12 December 2020

Anion conductance behavior of the glutamate uptake carrier in salamander retinal glial cells

1 reference

12 December 2020

Purification and identification of the functional sodium- and chloride-coupled gamma-aminobutyric acid transport glycoprotein from rat brain.

1 reference

12 December 2020

The reactivity of the gamma-aminobutyric acid transporter GAT-1 toward sulfhydryl reagents is conformationally sensitive. Identification of a major target residue

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12 December 2020

Conformational changes monitored on the glutamate transporter GLT-1 indicate the existence of two neurotransmitter-bound states

1 reference

12 December 2020

Cysteine scanning of the surroundings of an alkali-ion binding site of the glutamate transporter GLT-1 reveals a conformationally sensitive residue.

1 reference

12 December 2020

Non-vesicular release of glutamate from glial cells by reversed electrogenic glutamate uptake.

1 reference

12 December 2020

GAT1 (GABA:Na+:Cl-) cotransport function. Steady state studies in giant Xenopus oocyte membrane patches

1 reference

12 December 2020

Structure, expression, and functional analysis of a Na(+)-dependent glutamate/aspartate transporter from rat brain

1 reference

12 December 2020

The substrate specificity of a neuronal glutamate transporter is determined by the nature of the coupling ion.

1 reference

12 December 2020

GAT1 (GABA:Na+:Cl-) cotransport function. Kinetic studies in giant Xenopus oocyte membrane patches

1 reference

12 December 2020

Crystal structure of the calcium pump of sarcoplasmic reticulum at 2.6 A resolution

1 reference

12 December 2020

Identification and selective inhibition of the channel mode of the neuronal GABA transporter 1.

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12 December 2020

Ion-coupled neurotransmitter transport

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12 December 2020

Biotinylation of single cysteine mutants of the glutamate transporter GLT-1 from rat brain reveals its unusual topology.

1 reference

12 December 2020

Sulfhydryl modification of cysteine mutants of a neuronal glutamate transporter reveals an inverse relationship between sodium dependent conformational changes and the glutamate-gated anion conductance

1 reference

12 December 2020

Structure of a glutamate transporter homologue from Pyrococcus horikoshii

1 reference

12 December 2020

Determination of external loop topology in the serotonin transporter by site-directed chemical labeling

1 reference

12 December 2020

GAT1 (GABA:Na+:Cl-) cotransport function. Database reconstruction with an alternating access model

1 reference

12 December 2020

Transmembrane domains I and II of the gamma-aminobutyric acid transporter GAT-4 contain molecular determinants of substrate specificity

1 reference

12 December 2020

Cysteine-scanning mutagenesis reveals a conformationally sensitive reentrant pore-loop in the glutamate transporter GLT-1.

1 reference

12 December 2020

Cloning and expression of a rat brain GABA transporter

1 reference

12 December 2020

Engineered Zn(2+) switches in the gamma-aminobutyric acid (GABA) transporter-1. Differential effects on GABA uptake and currents

1 reference

12 December 2020

Coupled, but not uncoupled, fluxes in a neuronal glutamate transporter can be activated by lithium ions

1 reference

12 December 2020

The family of Na+/Cl- neurotransmitter transporters.

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12 December 2020

Conducting states of a mammalian serotonin transporter.

1 reference

12 December 2020

gamma-Aminobutyric acid transport in reconstituted preparations from rat brain: coupled sodium and chloride fluxes.

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12 December 2020

Active transport of gamma-aminobutyric acid by membrane vesicles isolated from rat brain

1 reference

12 December 2020

Primary structure and functional characterization of a high-affinity glutamate transporter

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12 December 2020

The open pore conformation of potassium channels

1 reference

12 December 2020

Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter

1 reference

12 December 2020

Active transport of L-glutamate by membrane vesicles isolated from rat brain

1 reference

12 December 2020

Electrogenic glutamate uptake is a major current carrier in the membrane of axolotl retinal glial cells

1 reference

12 December 2020

Kinetics of a human glutamate transporter.

1 reference

12 December 2020

Tyrosine 140 of the gamma-aminobutyric acid transporter GAT-1 plays a critical role in neurotransmitter recognition

1 reference

12 December 2020

Identification of a lithium interaction site in the gamma-aminobutyric acid (GABA) transporter GAT-1

1 reference

12 December 2020

Mutation of arginine 44 of GAT-1, a (Na(+) + Cl(-))-coupled gamma-aminobutyric acid transporter from rat brain, impairs net flux but not exchange

1 reference

12 December 2020

Neutralization of the aspartic acid residue Asp-367, but not Asp-454, inhibits binding of Na+ to the glutamate-free form and cycling of the glutamate transporter EAAC1.

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12 December 2020

Proximity of two oppositely oriented reentrant loops in the glutamate transporter GLT-1 identified by paired cysteine mutagenesis

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12 December 2020

Role of Cl- in electrogenic Na+-coupled cotransporters GAT1 and SGLT1.

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12 December 2020

Arginine 447 plays a pivotal role in substrate interactions in a neuronal glutamate transporter

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12 December 2020

Mutation of an amino acid residue influencing potassium coupling in the glutamate transporter GLT-1 induces obligate exchange

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12 December 2020

Retinal glial cell glutamate transporter is coupled to an anionic conductance

1 reference

12 December 2020

Molecular determinant of ion selectivity of a (Na+ + K+)-coupled rat brain glutamate transporter

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12 December 2020

Cloning and expression of a rat brain L-glutamate transporter

1 reference

12 December 2020

Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1

1 reference

12 December 2020

Ion binding and permeation at the GABA transporter GAT1.

1 reference

12 December 2020

Molecular physiology: intimate contact enables transport

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12 December 2020

Excitatory amino acid transporter 5, a retinal glutamate transporter coupled to a chloride conductance

1 reference

12 December 2020

Steady states, charge movements, and rates for a cloned GABA transporter expressed in Xenopus oocytes.

1 reference

12 December 2020

Crystal structure of a bacterial homologue of Na+/Cl--dependent neurotransmitter transporters

1 reference

12 December 2020

Distinct conformational states mediate the transport and anion channel properties of the glutamate transporter EAAT-1.

1 reference

12 December 2020

The chloride permeation pathway of a glutamate transporter and its proximity to the glutamate translocation pathway.

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12 December 2020

Arginine 445 Controls the Coupling between Glutamate and Cations in the Neuronal Transporter EAAC-1

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12 December 2020

The accessibility of a novel reentrant loop of the glutamate transporter GLT-1 is restricted by its substrate

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12 December 2020

Two serine residues of the glutamate transporter GLT-1 are crucial for coupling the fluxes of sodium and the neurotransmitter

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12 December 2020

Proximity of transmembrane domains 1 and 3 of the gamma-aminobutyric acid transporter GAT-1 inferred from paired cysteine mutagenesis

1 reference

12 December 2020

Mechanism of transport and storage of neurotransmitters.

1 reference

12 December 2020

Coupling between platelet 5-hydroxytryptamine and potassium transport

1 reference

12 December 2020

An excitatory amino-acid transporter with properties of a ligand-gated chloride channel

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12 December 2020

Binding order of substrates to the (sodium + potassium ion)-coupled L-glutamic acid transporter from rat brain

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12 December 2020

Only one of the charged amino acids located in the transmembrane alpha-helices of the gamma-aminobutyric acid transporter (subtype A) is essential for its activity.

1 reference

12 December 2020

Is the glutamate residue Glu-373 the proton acceptor of the excitatory amino acid carrier 1?

1 reference

12 December 2020

Transmembrane domain I of the gamma-aminobutyric acid transporter GAT-1 plays a crucial role in the transition between cation leak and transport modes

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12 December 2020

Sulfhydryl modification of V449C in the glutamate transporter EAAT1 abolishes substrate transport but not the substrate-gated anion conductance

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12 December 2020

Ion fluxes associated with excitatory amino acid transport.

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12 December 2020

Counterflow of L-glutamate in plasma membrane vesicles and reconstituted preparations from rat brain.

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12 December 2020

Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex

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12 December 2020

A conserved serine-rich stretch in the glutamate transporter family forms a substrate-sensitive reentrant loop

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12 December 2020

Homology modeling of the cation binding sites of Na+K+-ATPase

1 reference

12 December 2020

Engineering conformational flexibility in the lactose permease of Escherichia coli: use of glycine-scanning mutagenesis to rescue mutant Glu325-->Asp

1 reference

12 December 2020

Stoichiometry of the glial glutamate transporter GLT-1 expressed inducibly in a Chinese hamster ovary cell line selected for low endogenous Na+-dependent glutamate uptake.

1 reference

12 December 2020

Conformational basis for the Li(+)-induced leak current in the rat gamma-aminobutyric acid (GABA) transporter-1.

1 reference

12 December 2020

Transporter-associated currents in the gamma-aminobutyric acid transporter GAT-1 are conditionally impaired by mutations of a conserved glycine residue

1 reference

12 December 2020

10.1007/S00232-006-0877-5

Identifiers

DOI

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16 August 2017

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PubMed ID

17417704