UGT1A1*28 genotype and irinotecan dosage in patients with metastatic colorectal cancer: a Dutch Colorectal Cancer Group study. (Q36785973)

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9 January 2020

title

UGT1A1*28 genotype and irinotecan dosage in patients with metastatic colorectal cancer: a Dutch Colorectal Cancer Group study (English)

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9 January 2020

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metastatic colon cancer

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6

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9 January 2020

author name string

D M Kweekel

1

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9 January 2020

H Gelderblom

2

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9 January 2020

T Van der Straaten

3

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9 January 2020

N F Antonini

4

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9 January 2020

C J A Punt

5

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9 January 2020

Dutch Colorectal Cancer Group study

7

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9 January 2020

language of work or name

English

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publication date

1 July 2008

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British Journal of Cancer

9 January 2020

published in

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9 January 2020

volume

99

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9 January 2020

issue

2

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9 January 2020

page(s)

275-282

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UGT1A1*28 polymorphism predicts irinotecan-induced severe toxicities without affecting treatment outcome and survival in patients with metastatic colorectal carcinoma

9 January 2020

cites work

1 reference

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Sequential versus combination chemotherapy with capecitabine, irinotecan, and oxaliplatin in advanced colorectal cancer (CAIRO): a phase III randomised controlled trial

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Pharmacogenetics of irinotecan metabolism and transport: an update

29 September 2017

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New options and old dilemmas in the treatment of patients with advanced colorectal cancer

29 September 2017

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ABCG2 pharmacogenetics: ethnic differences in allele frequency and assessment of influence on irinotecan disposition

29 September 2017

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UGT1A1 gene variations and irinotecan treatment in patients with metastatic colorectal cancer

29 September 2017

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A 6 bp polymorphism in the thymidylate synthase gene causes message instability and is associated with decreased intratumoral TS mRNA levels

29 September 2017

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Genetic variants in the UDP-glucuronosyltransferase 1A1 gene predict the risk of severe neutropenia of irinotecan

29 September 2017

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Polymorphisms of UDP-glucuronosyltransferase gene and irinotecan toxicity: a pharmacogenetic analysis.

29 September 2017

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New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada

29 September 2017

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Genetic predisposition to the metabolism of irinotecan (CPT-11). Role of uridine diphosphate glucuronosyltransferase isoform 1A1 in the glucuronidation of its active metabolite (SN-38) in human liver microsomes

29 September 2017

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High dose-intensity of irinotecan administered every 3 weeks in advanced cancer patients: a feasibility study

29 September 2017

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Randomised study of sequential versus combination chemotherapy with capecitabine, irinotecan and oxaliplatin in advanced colorectal cancer, an interim safety analysis. A Dutch Colorectal Cancer Group (DCCG) phase III study.

29 September 2017

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UGT1A7 and UGT1A9 polymorphisms predict response and toxicity in colorectal cancer patients treated with capecitabine/irinotecan

5 September 2018

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Thymidylate synthase gene polymorphism predicts toxicity in colorectal cancer patients receiving 5-fluorouracil-based chemotherapy

5 September 2018

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Influence of genetic variants in UGT1A1 and UGT1A9 on the in vivo glucuronidation of SN-38.

5 September 2018

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High-dose, single-agent irinotecan as first-line therapy in the treatment of metastatic colorectal cancer

5 September 2018

1 reference

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UGT1A1*28 polymorphism as a determinant of irinotecan disposition and toxicity

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2480976

Thymidylate synthase gene polymorphism determines response and toxicity of 5-FU chemotherapy

5 September 2018

1 reference

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Polymorphisms of UDP-glucuronosyltransferase and pharmacokinetics of irinotecan.

5 September 2018

1 reference

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Frequency of single nucleotide polymorphisms in the P-glycoprotein drug transporter MDR1 gene in white subjects.

5 September 2018

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Cancer incidence and mortality in Europe, 2004

5 September 2018

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Crossref

https://api.crossref.org/works/10.1038%2FSJ.BJC.6604461

A novel single nucleotide polymorphism within the 5' tandem repeat polymorphism of the thymidylate synthase gene abolishes USF-1 binding and alters transcriptional activity

21 January 2018

1 reference

12 December 2020

Phase I and pharmacologic studies of the camptothecin analog irinotecan administered every 3 weeks in cancer patients

1 reference

12 December 2020

UGT1A1 genotypes and glucuronidation of SN-38, the active metabolite of irinotecan

1 reference

12 December 2020

Phenotype-genotype correlation of in vitro SN-38 (active metabolite of irinotecan) and bilirubin glucuronidation in human liver tissue with UGT1A1 promoter polymorphism

1 reference

12 December 2020

The Role of UGT1A1*28 Polymorphism in the Pharmacodynamics and Pharmacokinetics of Irinotecan in Patients With Metastatic Colorectal Cancer

1 reference

12 December 2020

Irinotecan combined with bolus fluorouracil, continuous infusion fluorouracil, and high-dose leucovorin every two weeks (LV5FU2 regimen): a clinical dose-finding and pharmacokinetic study in patients with pretreated metastatic colorectal cancer

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12 December 2020

Identifiers

DOI

10.1038/SJ.BJC.6604461

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18594531%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18594531%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

PubMed publication ID

18594531

1 reference