The IL-6/sIL-6R complex as a novel target for therapeutic approaches (Q36804420)

16 August 2017

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title

The IL-6/sIL-6R complex as a novel target for therapeutic approaches (English)

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16 August 2017

4

Joachim Grötzinger

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Stefan Rose-John

object named as

Stefan Rose-John

1

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author name string

Georg H Waetzig

2

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16 August 2017

Jürgen Scheller

3

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16 August 2017

Joachim Grötzinger

4

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16 August 2017

Dirk Seegert

5

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16 August 2017

language of work or name

English

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publication date

1 May 2007

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Expert Opinion on Therapeutic Targets

16 August 2017

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16 August 2017

11

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16 August 2017

5

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16 August 2017

613-624

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Haemopoietic receptors and helical cytokines

16 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.613

Gp130 and the interleukin-6 family of cytokines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.613

WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.613

New IL-6 (gp130) family cytokine members, CLC/NNT1/BSF3 and IL-27.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.613

Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.613

Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.613

IL-6 type cytokine receptor complexes: hexamer, tetramer or both?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.613

Molecular mechanisms of cytokine receptor activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.613

IL6 signalling through IL6 receptor and receptor-associated signal transducer, gp130

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.613

Protein kinase C activity is rate limiting for shedding of the interleukin-6 receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.613

The soluble interleukin-6 receptor is generated by shedding

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.613

Isolation of an mRNA encoding a soluble form of the human interleukin-6 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.613

Soluble interleukin-6 receptors released from T cell or granulocyte/macrophage cell lines and human peripheral blood mononuclear cells are generated through an alternative splicing mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.613

Extramedullary expansion of hematopoietic progenitor cells in interleukin (IL)-6-sIL-6R double transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.613

Transcriptional profiling identifies Id2 function in dendritic cell development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.613

Multilevel regulation of IL-6R by IL-6-sIL-6R fusion protein according to the primitiveness of peripheral blood-derived CD133+ cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.613

Blockade of interleukin 6 trans signaling suppresses T-cell resistanceagainst apoptosis in chronic intestinal inflammation: Evidence in Crohn diseaseand experimental colitis in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.613

TGF-beta suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.613

Maintenance of pluripotency in human embryonic stem cells is STAT3 independent

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.613

Sympathetic neurons can produce and respond to interleukin 6

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.613

Neural activities of IL-6-type cytokines often depend on soluble cytokine receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.613

Role of interleukin-6 and soluble IL-6 receptor in region-specific induction of astrocytic differentiation and neurotrophin expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.613

Interplay between IFN-gamma and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.613

Role of IL-6 and its soluble receptor in induction of chemokines and leukocyte recruitment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.613

The interleukin-6 cytokine system regulates epidermal permeability barrier homeostasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.613

Interferon beta 2/B-cell stimulatory factor type 2 shares identity with monocyte-derived hepatocyte-stimulating factor and regulates the major acute phase protein response in liver cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.613

Combination of interleukin-6 and soluble interleukin-6 receptors induces differentiation and activation of JAK-STAT and MAP kinase pathways in MG-63 human osteoblastic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.613

Soluble interleukin-6 receptors in inflammatory bowel disease: relation to circulating interleukin-6

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.613

A possible role for soluble IL-6 receptor in the pathogenesis of systemic onset juvenile chronic arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.613

Serum levels of interleukin-6 type cytokines and soluble interleukin-6 receptor in patients with rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.613

Bone marrow, cytokines, and bone remodeling. Emerging insights into the pathophysiology of osteoporosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.613

Evidence for the involvement of interleukin 6 in experimental cancer cachexia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.613

Prevalence of hypophosphatemia in sepsis and infection: the role of cytokines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.613

CSF and serum levels of soluble interleukin-6 receptors (sIL-6R and sgp130), but not of interleukin-6 are altered in multiple sclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.613

Interleukin-6 (IL-6) and soluble forms of IL-6 receptors are not altered in cerebrospinal fluid of Alzheimer's disease patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.613

Decreased soluble interleukin-6 receptor in cerebrospinal fluid of patients with Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.613

Role of interleukin 6 in the growth of myeloma-derived cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.613

Hodgkin and Reed-Sternberg cells express interleukin 6 and interleukin 6 receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.613

High-level production of alternatively spliced soluble interleukin-6 receptor in serum of patients with adult T-cell leukaemia/HTLV-I-associated myelopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.613

Interleukin 6 induces human immunodeficiency virus expression in infected monocytic cells alone and in synergy with tumor necrosis factor alpha by transcriptional and post-transcriptional mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.613

Inhibition of IL-6 for the treatment of inflammatory diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.613

Interleukin-6: a new therapeutic target

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.613

Receptor blockade with monoclonal antibodies as anti-cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.613

The therapy of autoimmune diseases by anti-interleukin-6 receptor antibody

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.613

Cytokine traps: multi-component, high-affinity blockers of cytokine action

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.613

Soluble gp130 is the natural inhibitor of soluble interleukin-6 receptor transsignaling responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.613

CLF associates with CLC to form a functional heteromeric ligand for the CNTF receptor complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.613

Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.613

Signaling mechanisms through cytokine receptors that share signal transducing receptor components

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.613

Dynamics of the gp130 cytokine complex: a model for assembly on the cellular membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.613

Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.613

Retrograde inflammatory signaling from neutrophils to endothelial cells by soluble interleukin-6 receptor alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.613

IL-6 is an antiinflammatory cytokine required for controlling local or systemic acute inflammatory responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.613

Association of recombinant soluble IL-6-signal transducer, gp130, with a complex of IL 6 and soluble IL-6 receptor, and establishment of an ELISA for soluble gp130

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.613

No inhibition of IL-27 signaling by soluble gp130.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.613

Cloning and expression of an alternatively spliced mRNA encoding a soluble form of the human interleukin-6 signal transducer gp130

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.613

Development of a monoclonal antibody-based enzyme-linked immunoabsorbent assay for the binding of gp130 to the IL-6/IL-6R complex and its competitive inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.613

Inhibition of Th1 responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.613

The designer cytokine hyper-interleukin-6 is a potent activator of STAT3-dependent gene transcription in vivo and in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.613

Anti-tumour necrosis factor agents and tuberculosis risk: mechanisms of action and clinical management

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.613

Interleukin-6 and its receptor: from bench to bedside

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.613

The role of transsignalling via the agonistic soluble IL-6 receptor in human diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.613

Interleukin 6 plays a key role in the development of antigen-induced arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.613

Interleukin 6 is required for the development of collagen-induced arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.613

Pathological role of IL-6 in the experimental allergic bronchial asthma in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.613

The IL-6R alpha chain controls lung CD4+CD25+ Treg development and function during allergic airway inflammation in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.613

Treatment of rheumatoid arthritis with humanized anti-interleukin-6 receptor antibody: a multicenter, double-blind, placebo-controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.613

Anti-cytokine therapeutics and infections

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.613

21 January 2018

The world of biologics.

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.613

Novel therapy for Crohn's disease targeting IL-6 signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.613

10.1517/14728222.11.5.613

21 January 2018

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DOI

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16 August 2017

1 reference