The potential for phospholipase D as a new therapeutic target (Q36804452)

16 August 2017

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title

The potential for phospholipase D as a new therapeutic target (English)

1 reference

16 August 2017

Ping Huang

1

1 reference

PubMed ID

17465727

16 August 2017

Michael A Frohman

series ordinal

2

1 reference

PubMed ID

17465727

16 August 2017

language of work or name

English

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publication date

1 May 2007

1 reference

Expert Opinion on Therapeutic Targets

16 August 2017

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16 August 2017

11

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16 August 2017

5

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16 August 2017

707-716

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Phospholipase D: molecular and cell biology of a novel gene family

16 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.707

Human ADP-ribosylation factor-activated phosphatidylcholine-specific phospholipase D defines a new and highly conserved gene family

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.707

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.707

Phospholipase D: a lipid centric review

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.707

Phospholipid signalling through phospholipase D and phosphatidic acid.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.707

Inositol lipids as spatial regulators of membrane traffic

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.707

Mammalian lipid phosphate phosphohydrolases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.707

A novel cytosolic calcium-independent phospholipase A2 contains eight ankyrin motifs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.707

Mutagenesis of phospholipase D defines a superfamily including a trans-Golgi viral protein required for poxvirus pathogenicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.707

Crystal structure of a phospholipase D family member

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.707

Structural analysis of human phospholipase D1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.707

ADP-ribosylation factor, a small GTP-dependent regulatory protein, stimulates phospholipase D activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.707

Characterization of two alternately spliced forms of phospholipase D1. Activation of the purified enzymes by phosphatidylinositol 4,5-bisphosphate, ADP-ribosylation factor, and Rho family monomeric GTP-binding proteins and protein kinase C-alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.707

Induction of inducible nitric-oxide synthase by the heterotrimeric G protein Galpha13.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.707

Loss of receptor regulation by a phospholipase D1 mutant unresponsive to protein kinase C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.707

A common lipid links Mfn-mediated mitochondrial fusion and SNARE-regulated exocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.707

The tyrosyl-DNA phosphodiesterase Tdp1 is a member of the phospholipase D superfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.707

Hu-K4 is a ubiquitously expressed type 2 transmembrane protein associated with the endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.707

Cloning and initial characterization of a human phospholipase D2 (hPLD2). ADP-ribosylation factor regulates hPLD2

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.707

Phospholipase D2, a distinct phospholipase D isoform with novel regulatory properties that provokes cytoskeletal reorganization

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.707

Colocalization of phospholipase D1 and GTP-binding-defective mutant of ADP-ribosylation factor 6 to endosomes and lysosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.707

Phospholipase D1: a key factor for the exocytotic machinery in neuroendocrine cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.707

Phospholipase D1 localises to secretory granules and lysosomes and is plasma-membrane translocated on cellular stimulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.707

Regulation of phospholipase D1 subcellular cycling through coordination of multiple membrane association motifs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.707

Phospholipase D1 regulates secretagogue-stimulated insulin release in pancreatic beta-cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.707

Insulin-stimulated plasma membrane fusion of Glut4 glucose transporter-containing vesicles is regulated by phospholipase D1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.707

Phosphatidylinositol 4-phosphate 5-kinase alpha is a downstream effector of the small G protein ARF6 in membrane ruffle formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.707

Phospholipase D2 localizes to the plasma membrane and regulates angiotensin II receptor endocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.707

Evidence that phospholipase D mediates ADP ribosylation factor-dependent formation of Golgi coated vesicles

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.707

Phospholipase D stimulates release of nascent secretory vesicles from the trans-Golgi network

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.707

Inhibition of phosphatidic acid synthesis alters the structure of the Golgi apparatus and inhibits secretion in endocrine cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.707

Role of phosphoinositide signaling in the control of insulin exocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.707

A role for phospholipase D1 in neurotransmitter release.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.707

Interdependent assembly of specific regulatory lipids and membrane fusion proteins into the vertex ring domain of docked vacuoles

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.707

Phospholipase A(2)-mediated fusion of neutrophil-derived membranes is augmented by phosphatidic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.707

Asymmetric phospholipid distribution drives in vitro reconstituted SNARE-dependent membrane fusion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.707

A fuzzy mitochondrial fusion apparatus comes into focus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.707

Mitochondria: dynamic organelles in disease, aging, and development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.707

Nuclear gene OPA1, encoding a mitochondrial dynamin-related protein, is mutated in dominant optic atrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.707

ADP-ribosylation factor-dependent phospholipase D2 activation is required for agonist-induced mu-opioid receptor endocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.707

Dynamics and function of phospholipase D and phosphatidic acid during phagocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.707

Role of phospholipase D2 in the agonist-induced and constitutive endocytosis of G-protein coupled receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.707

Role for phospholipase D in receptor-mediated endocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.707

The phox homology domain of phospholipase D activates dynamin GTPase activity and accelerates EGFR endocytosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.707

Phospholipase D2 is required for efficient endocytic recycling of transferrin receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.707

Ral and phospholipase D2-dependent pathway for constitutive metabotropic glutamate receptor endocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.707

Phospholipase D prevents apoptosis in v-Src-transformed rat fibroblasts and MDA-MB-231 breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.707

Overexpression of phospholipase D prevents actinomycin D-induced apoptosis through potentiation of phosphoinositide 3-kinase signalling pathways in Chinese-hamster ovary cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.707

Phospholipase D prevents etoposide-induced apoptosis by inhibiting the expression of early growth response-1 and phosphatase and tensin homologue deleted on chromosome 10.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.707

Overexpression of protein kinase C-epsilon and its regulatory domains in fibroblasts inhibits phorbol ester-induced phospholipase D activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.707

Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.707

Involvement of phospholipase D in sphingosine 1-phosphate-induced activation of phosphatidylinositol 3-kinase and Akt in Chinese hamster ovary cells overexpressing EDG3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.707

Phosphatidic acid-mediated mitogenic activation of mTOR signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.707

Phospholipase D confers rapamycin resistance in human breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.707

Alternative phospholipase D/mTOR survival signal in human breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.707

mTOR-dependent suppression of protein phosphatase 2A is critical for phospholipase D survival signals in human breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.707

Phospholipase D couples survival and migration signals in stress response of human cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.707

Inhibition of phospholipase D activity by fodrin. An active role for the cytoskeleton.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.707

Synaptojanin inhibition of phospholipase D activity by hydrolysis of phosphatidylinositol 4,5-bisphosphate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.707

Inhibition of phospholipase D by clathrin assembly protein 3 (AP3).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.707

Regulation of phospholipase D2: selective inhibition of mammalian phospholipase D isoenzymes by alpha- and beta-synucleins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.707

Structural determinants of PLD2 inhibition by alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.707

Yeast cells provide insight into alpha-synuclein biology and pathobiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.707

The TOR pathway: a target for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.707

Reduced phospholipase D activity in brain tissue samples from Alzheimer's disease patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.707

Phospholipid metabolism in Alzheimer's disease and in a human cholinergic cell

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.707

Phospholipase D1 is up-regulated in the mitochondrial fraction from the brains of Alzheimer's disease patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.707

Traffic jams II: an update of diseases of intracellular transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.707

Genomewide search for type 2 diabetes-susceptibility genes in French whites: evidence for a novel susceptibility locus for early-onset diabetes on chromosome 3q27-qter and independent replication of a type 2-diabetes locus on chromosome 1q21-q24.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.707

RNA interference and human disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.707

Potential applications of RNA interference technology in the treatment of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.707

Therapeutic potential of RNA interference for neurological disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.707

Viral-based modelling and correction of neurodegenerative diseases by RNA interference.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.707

siRNA-based approaches in cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.707

The silent treatment: siRNAs as small molecule drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.707

siRNA-mediated gene silencing in vitro and in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.707

PGC-1 promotes insulin resistance in liver through PPAR-alpha-dependent induction of TRB-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.707

Therapeutic EphA2 gene targeting in vivo using neutral liposomal small interfering RNA delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.707

Phospholipase D-structure, regulation and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.707

Phospholipase D: a downstream effector of ARF in granulocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.707

ARF and PITP restore GTPγS-stimulated protein secretion from cytosol-depleted HL60 cells by promoting PIP2 synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.5.707

10.1517/14728222.11.5.707

21 January 2018

Identifiers

DOI

1 reference

16 August 2017

1 reference

PubMed ID

17465727