Harnessing calcineurin as a novel anti-infective agent against invasive fungal infections (Q36823712)

16 August 2017

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title

Harnessing calcineurin as a novel anti-infective agent against invasive fungal infections (English)

1 reference

calcineurin a catalytic subunit

16 August 2017

main subject

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GeneDB

invasive fungal infections

6 February 2019

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5

Joseph Heitman

1 reference

16 August 2017

4

John R Perfect

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16 August 2017

1

William J Steinbach

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16 August 2017

Jennifer L Reedy

2

1 reference

16 August 2017

Robert A Cramer

series ordinal

3

1 reference

16 August 2017

language of work or name

English

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publication date

1 June 2007

1 reference

Nature Reviews Microbiology

16 August 2017

published in

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16 August 2017

volume

5

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16 August 2017

issue

6

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16 August 2017

page(s)

418-430

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A rare genotype of Cryptococcus gattii caused the cryptococcosis outbreak on Vancouver Island (British Columbia, Canada)

16 August 2017

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Immunosuppressant FK506 enhances phosphorylation of nitric oxide synthase and protects against glutamate neurotoxicity

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Calcineurin mediates alpha-adrenergic stimulation of Na+,K(+)-ATPase activity in renal tubule cells

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Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation

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Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

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Two cytoplasmic candidates for immunophilin action are revealed by affinity for a new cyclophilin: one in the presence and one in the absence of CsA

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Calcineurin/NFAT signalling regulates pancreatic beta-cell growth and function

31 March 2020

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Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature

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Inducible and reversible enhancement of learning, memory, and long-term potentiation by genetic inhibition of calcineurin.

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Reversible blockade of experience-dependent plasticity by calcineurin in mouse visual cortex.

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Activity-dependent regulation of MEF2 transcription factors suppresses excitatory synapse number

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Neurotrophins and netrins require calcineurin/NFAT signaling to stimulate outgrowth of embryonic axons

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A field of myocardial-endocardial NFAT signaling underlies heart valve morphogenesis

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Truncation and activation of calcineurin A by calpain I in Alzheimer disease brain

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Prevention of Cardiac Hypertrophy in Mice by Calcineurin Inhibition

31 March 2020

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Inherent calcineurin inhibitor FKBP38 targets Bcl-2 to mitochondria and inhibits apoptosis

31 March 2020

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NFAT and Osterix cooperatively regulate bone formation

31 March 2020

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Skeletal muscle hypertrophy is mediated by a Ca2+-dependent calcineurin signalling pathway

31 March 2020

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Methotrexate and cyclosporine compared with cyclosporine alone for prophylaxis of acute graft versus host disease after marrow transplantation for leukemia

31 March 2020

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Long-term Safety and Efficacy of Tacrolimus Ointment for the Treatment of Atopic Dermatitis in Children

31 March 2020

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Trial of cyclosporin in corticosteroid-dependent chronic severe asthma

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Infliximab treatment in combination with cyclosporin A in patients with severe refractory rheumatoid arthritis

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Crystal structure of human calcineurin complexed with cyclosporin A and human cyclophilin

31 March 2020

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Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes

31 March 2020

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Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex

31 March 2020

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X-ray structure of calcineurin inhibited by the immunophilin-immunosuppressant FKBP12-FK506 complex

31 March 2020

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Treatment of murine cryptococcosis with cyclosporin-A in normal and athymic mice

31 March 2020

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Calcineurin is required for virulence of Cryptococcus neoformans

31 March 2020

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Calcineurin, Mpk1 and Hog1 MAPK pathways independently control fludioxonil antifungal sensitivity in Cryptococcus neoformans

31 March 2020

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Calcineurin is required for hyphal elongation during mating and haploid fruiting in Cryptococcus neoformans

31 March 2020

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Two cyclophilin A homologs with shared and distinct functions important for growth and virulence of Cryptococcus neoformans

31 March 2020

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Calcium- and calcineurin-independent roles for calmodulin in Cryptococcus neoformans morphogenesis and high-temperature growth

31 March 2020

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Identification and characterization of a highly conserved calcineurin binding protein, CBP1/calcipressin, in Cryptococcus neoformans

31 March 2020

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Calcineurin-binding protein Cbp1 directs the specificity of calcineurin-dependent hyphal elongation during mating in Cryptococcus neoformans

31 March 2020

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Phospholipid-binding protein Cts1 controls septation and functions coordinately with calcineurin in Cryptococcus neoformans

31 March 2020

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The Cryptococcus neoformans MAP kinase Mpk1 regulates cell integrity in response to antifungal drugs and loss of calcineurin function

31 March 2020

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Immunosuppressive and nonimmunosuppressive cyclosporine analogs are toxic to the opportunistic fungal pathogen Cryptococcus neoformans via cyclophilin-dependent inhibition of calcineurin

31 March 2020

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Synergistic antifungal activities of bafilomycin A(1), fluconazole, and the pneumocandin MK-0991/caspofungin acetate (L-743,873) with calcineurin inhibitors FK506 and L-685,818 against Cryptococcus neoformans

31 March 2020

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Calcineurin regulatory subunit is essential for virulence and mediates interactions with FKBP12-FK506 in Cryptococcus neoformans

31 March 2020

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Cryptococcus neoformans in organ transplant recipients: impact of calcineurin-inhibitor agents on mortality

31 March 2020

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Antifungal attributes of immunosuppressive agents: new paradigms in management and elucidating the pathophysiologic basis of opportunistic mycoses in organ transplant recipients

31 March 2020

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Cryptococcus neoformans isolates from transplant recipients are not selected for resistance to calcineurin inhibitors by current immunosuppressive regimens

31 March 2020

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The epidemiology of sepsis in the United States from 1979 through 2000

31 March 2020

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Changes in the spectrum and risk factors for invasive candidiasis in liver transplant recipients: prospective, multicenter, case-controlled study1

31 March 2020

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Calcineurin is essential for survival during membrane stress in Candida albicans

31 March 2020

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Calcineurin is essential for virulence in Candida albicans

31 March 2020

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Calcineurin is essential for Candida albicans survival in serum and virulence

31 March 2020

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Calcineurin A of Candida albicans: involvement in antifungal tolerance, cell morphogenesis and virulence

31 March 2020

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Role of calcineurin in stress resistance, morphogenesis, and virulence of a Candida albicans wild-type strain

31 March 2020

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Candida Albicans: a molecular revolution built on lessons from budding yeast

31 March 2020

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Virulence factors of Candida albicans

31 March 2020

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Putative virulence factors of Candida albicans

31 March 2020

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Candida albicans hyphal formation and the expression of the Efg1-regulated proteinases Sap4 to Sap6 are required for the invasion of parenchymal organs

31 March 2020

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Nonfilamentous C. albicans mutants are avirulent

31 March 2020

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Dimorphism and virulence in Candida albicans

31 March 2020

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Candida albicans proteinases and host/pathogen interactions

31 March 2020

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Adhesins in Candida albicans

31 March 2020

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Essential role of the Candida albicans transglutaminase substrate, hyphal wall protein 1, in lethal oroesophageal candidiasis in immunodeficient mice

31 March 2020

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CRZ1, a target of the calcineurin pathway in Candida albicans

31 March 2020

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The calcineurin target, Crz1, functions in azole tolerance but is not required for virulence of Candida albicans

31 March 2020

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Functional characterization of the Candida albicans CRZ1 gene encoding a calcineurin-regulated transcription factor

31 March 2020

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Calcineurin-dependent regulation of Crz1p nuclear export requires Msn5p and a conserved calcineurin docking site

31 March 2020

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Calcineurin signaling in Saccharomyces cerevisiae: how yeast go crazy in response to stress

31 March 2020

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Tcn1p/Crz1p, a calcineurin-dependent transcription factor that differentially regulates gene expression in Saccharomyces cerevisiae

31 March 2020

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Promoter sequences regulated by the calcineurin-activated transcription factor Crz1 in the yeast ENA1 gene.

31 March 2020

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Calcineurin-dependent nuclear import of the transcription factor Crz1p requires Nmd5p

31 March 2020

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Calcineurin acts through the CRZ1/TCN1-encoded transcription factor to regulate gene expression in yeast

31 March 2020

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Yeast calcineurin regulates nuclear localization of the Crz1p transcription factor through dephosphorylation

31 March 2020

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Genome-wide analysis of gene expression regulated by the calcineurin/Crz1p signaling pathway in Saccharomyces cerevisiae

31 March 2020

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The CRH family coding for cell wall glycosylphosphatidylinositol proteins with a predicted transglycosidase domain affects cell wall organization and virulence of Candida albicans.

31 March 2020

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Genetic architecture of Hsp90-dependent drug resistance

31 March 2020

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Hph1p and Hph2p, novel components of calcineurin-mediated stress responses in Saccharomyces cerevisiae

31 March 2020

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Potent synergism of the combination of fluconazole and cyclosporine in Candida albicans

31 March 2020

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31 March 2020

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Ergosterol biosynthesis inhibitors become fungicidal when combined with calcineurin inhibitors against Candida albicans, Candida glabrata, and Candida krusei

31 March 2020

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Anti-Candida drugs--the biochemical basis for their activity

31 March 2020

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Fungicidal synergism of fluconazole and cyclosporine in Candida albicans is not dependent on multidrug efflux transporters encoded by the CDR1, CDR2, CaMDR1, and FLU1 genes.

31 March 2020

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Immunotherapy with tacrolimus (FK506) does not select for resistance to calcineurin inhibitors in Candida albicans isolates from liver transplant patients

31 March 2020

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Calcineurin promotes infection of the cornea by Candida albicans and can be targeted to enhance fluconazole therapy

31 March 2020

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Hsp90 potentiates the rapid evolution of new traits: drug resistance in diverse fungi

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Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin

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Cell biology. A fungal Achilles' heel

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Trends in mortality due to invasive mycotic diseases in the United States, 1980-1997.

31 March 2020

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Bad bugs need drugs: an update on the development pipeline from the Antimicrobial Availability Task Force of the Infectious Diseases Society of America

31 March 2020

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The calmodulin-dependent protein phosphatase catalytic subunit (calcineurin A) is an essential gene in Aspergillus nidulans

31 March 2020

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Cloning and sequence analysis of cnaA gene encoding the catalytic subunit of calcineurin from Aspergillus oryzae

31 March 2020

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Functional analysis of the calcineurin-encoding gene cnaA from Aspergillus oryzae: evidence for its putative role in stress adaptation

31 March 2020

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The Aspergillus niger cypA gene encodes a cyclophilin that mediates sensitivity to the immunosuppressant cyclosporin A.

31 March 2020

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Regulation of aflatoxin production by Ca(2+)/calmodulin-dependent protein phosphorylation and dephosphorylation

31 March 2020

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Calcineurin controls growth, morphology, and pathogenicity in Aspergillus fumigatus

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Functional characterization of the Aspergillus fumigatus calcineurin.

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The akuB(KU80) mutant deficient for nonhomologous end joining is a powerful tool for analyzing pathogenicity in Aspergillus fumigatus

31 March 2020

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Effects of methylprednisolone and cyclosporine A on fungal growth in vitro.

31 March 2020

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Structural and biological characterization of chromofungin, the antifungal chromogranin A-(47-66)-derived peptide

31 March 2020

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Combination of caspofungin with inhibitors of the calcineurin pathway attenuates growth in vitro in Aspergillus species

31 March 2020

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In vitro interactions between antifungals and immunosuppressants against Aspergillus fumigatus

31 March 2020

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In vitro interactions between antifungals and immunosuppressants against Aspergillus fumigatus isolates from transplant and nontransplant patients

31 March 2020

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Trends in Risk Profiles for and Mortality Associated with Invasive Aspergillosis among Liver Transplant Recipients

31 March 2020

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Pathogenesis of pulmonary aspergillosis. Granulocytopenia versus cyclosporine and methylprednisolone-induced immunosuppression

31 March 2020

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Invasive aspergillosis in mice immunosuppressed with cyclosporin A, tacrolimus (FK506), or sirolimus (rapamycin).

31 March 2020

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Comparative safety of amphotericin B lipid complex and amphotericin B deoxycholate as aerosolized antifungal prophylaxis in lung-transplant recipients

31 March 2020

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A Randomized Trial of Inhaled Cyclosporine in Lung-Transplant Recipients

31 March 2020

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Aerosol cyclosporin therapy in lung transplant recipients with bronchiolitis obliterans

31 March 2020

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Calcineurin is required for Candida albicans to survive calcium stress in serum

31 March 2020

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Effects of cyclosporine in experimental cryptococcal meningitis.

31 March 2020

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRMICRO1680

1 reference

release_cagq4zmk3rhuhbas7agtuzsszq

16 August 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/cagq4zmk3rhuhbas7agtuzsszq

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference