Nerve growth factor gene delivery: animal models to clinical trials (Q36827338)

16 August 2017

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title

Nerve growth factor gene delivery: animal models to clinical trials (English)

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16 August 2017

1

Mark H Tuszynski

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16 August 2017

1 August 2007

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16 August 2017

12

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Developmental Neurobiology

inferred from page(s)

published in

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16 August 2017

67

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16 August 2017

9

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16 August 2017

1204-1215

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Nerve growth factor reverses neuronal atrophy in a Down syndrome model of age-related neurodegeneration

16 August 2017

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.20510

Immunohistochemical localization of cells containing nerve growth factor receptors in the different regions of the adult rat forebrain

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.20510

Randomized, double-blind trial of glial cell line-derived neurotrophic factor (GDNF) in PD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.20510

Trk neurotrophin receptors in cholinergic neurons of patients with Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.20510

Induction of long-term potentiation and depression is reflected by corresponding changes in secretion of endogenous brain-derived neurotrophic factor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.20510

7 January 2021

Longitudinal PET Evaluation of Cerebral Metabolic Decline in Dementia: A Potential Outcome Measure in Alzheimer's Disease Treatment Studies

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.20510

7 January 2021

Long-term clinical improvement in MPTP-lesioned primates after gene therapy with AAV-hAADC.

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.20510

7 January 2021

Regulated lentiviral NGF gene transfer controls rescue of medial septal cholinergic neurons

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.20510

7 January 2021

Retrograde transport of neurotrophins: fact and function

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.20510

7 January 2021

Somatic gene transfer of NGF to the aged brain: behavioral and morphological amelioration

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.20510

7 January 2021

AAV hybrid serotypes: improved vectors for gene delivery

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.20510

7 January 2021

Down-regulation of trkA mRNA within nucleus basalis neurons in individuals with mild cognitive impairment and Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.20510

7 January 2021

The basal forebrain cholinergic system is essential for cortical plasticity and functional recovery following brain injury

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.20510

7 January 2021

Lesions of the Basal forebrain cholinergic system impair task acquisition and abolish cortical plasticity associated with motor skill learning

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.20510

7 January 2021

Nontropic actions of neurotrophins: subcortical nerve growth factor gene delivery reverses age-related degeneration of primate cortical cholinergic innervation

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.20510

7 January 2021

Failed retrograde transport of NGF in a mouse model of Down's syndrome: reversal of cholinergic neurodegenerative phenotypes following NGF infusion

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.20510

7 January 2021

Detection of NGF-like activity in human brain tissue: increased levels in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.20510

7 January 2021

Impaired axonal transport of cortical neurons in Alzheimer's disease is associated with neuropathological changes

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.20510

7 January 2021

A double-blind, placebo-controlled multicenter study of tacrine for Alzheimer's disease. The Tacrine Collaborative Study Group.

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.20510

7 January 2021

Coexistence of choline acetyltransferase and nerve growth factor receptors in the rat basal forebrain

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.20510

7 January 2021

Delayed treatment with nerve growth factor improves acquisition of a spatial task in rats with lesions of the nucleus basalis magnocellularis: evaluation of the involvement of different neurotransmitter systems

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.20510

7 January 2021

Implants of polymer-encapsulated human NGF-secreting cells in the nonhuman primate: rescue and sprouting of degenerating cholinergic basal forebrain neurons

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.20510

7 January 2021

Distribution of radioiodinated recombinant human nerve growth factor in primate brain following intracerebroventricular infusion.

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.20510

7 January 2021

Intracerebroventricular infusion of nerve growth factor in three patients with Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.20510

7 January 2021

Nerve growth factor mRNA and protein levels measured in the same tissue from normal and Alzheimer's disease parietal cortex.

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.20510

7 January 2021

Amelioration of cholinergic neuron atrophy and spatial memory impairment in aged rats by nerve growth factor.

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.20510

7 January 2021

Functional recovery in parkinsonian monkeys treated with GDNF

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.20510

7 January 2021

Direct brain infusion of glial cell line-derived neurotrophic factor in Parkinson disease

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.20510

7 January 2021

A double-blind placebo-controlled clinical trial of subcutaneous recombinant human ciliary neurotrophic factor (rHCNTF) in amyotrophic lateral sclerosis. ALS CNTF Treatment Study Group

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.20510

7 January 2021

A controlled trial of recombinant methionyl human BDNF in ALS: The BDNF Study Group (Phase III)

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.20510

7 January 2021

Treatment of Alzheimer's disease: rationale and strategies

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.20510

7 January 2021

Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.20510

7 January 2021

NGF content in the cerebral cortex of non-demented patients with amyloid-plaques and in symptomatic Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.20510

7 January 2021

Region-Specific Neurotrophin Imbalances in Alzheimer Disease

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.20510

7 January 2021

p140trk mRNA marks NGF-responsive forebrain neurons: evidence that trk gene expression is induced by NGF

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.20510

7 January 2021

Signaling endosome hypothesis: A cellular mechanism for long distance communication

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.20510

7 January 2021

Differential modulation of the cholinergic phenotype of the nucleus basalis magnocellularis neurons by applying NGF at the cell body or cortical terminal fields

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.20510

7 January 2021

Intracerebral NGF infusion induces hyperinnervation of cerebral blood vessels

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.20510

7 January 2021

Neurotrophin signal transduction in the nervous system

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.20510

7 January 2021

NGF gene transfer to intrinsic basal forebrain neurons increases cholinergic cell size and protects from age-related, spatial memory deficits in middle-aged rats

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.20510

7 January 2021

Human nerve growth factor prevents degeneration of basal forebrain cholinergic neurons in primates

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.20510

7 January 2021

Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.20510

7 January 2021

Clinicopathological findings following intraventricular glial-derived neurotrophic factor treatment in a patient with Parkinson's disease

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.20510

7 January 2021

The aged monkey basal forebrain: rescue and sprouting of axotomized basal forebrain neurons after grafts of encapsulated cells secreting human nerve growth factor

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.20510

7 January 2021

Nerve growth factor treatment after brain injury prevents neuronal death

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.20510

7 January 2021

The nerve growth factor 35 years later

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.20510

7 January 2021

Selective growth stimulating effects of mouse sarcoma on the sensory and sympathetic nervous system of the chick embryo

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.20510

7 January 2021

Long-term protective effects of human recombinant nerve growth factor and monosialoganglioside GM1 treatment on primate nucleus basalis cholinergic neurons after neocortical infarction

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.20510

7 January 2021

Clogging of axons by tau, inhibition of axonal traffic and starvation of synapses.

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.20510

7 January 2021

Human nerve growth factor improves spatial memory in aged but not in young rats.

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.20510

7 January 2021

Processing in layer 4 of the neocortical circuit: new insights from visual and somatosensory cortex

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.20510

7 January 2021

Loss of nerve growth factor receptor-containing neurons in Alzheimer's disease: a quantitative analysis across subregions of the basal forebrain

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.20510

7 January 2021

Nerve growth factor in Alzheimer's disease: defective retrograde transport to nucleus basalis.

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.20510

7 January 2021

Human cholinergic basal forebrain: chemoanatomy and neurologic dysfunction.

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.20510

7 January 2021

Preservation of brain nerve growth factor in mild cognitive impairment and Alzheimer disease.

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.20510

7 January 2021

Loss of basal forebrain P75(NTR) immunoreactivity in subjects with mild cognitive impairment and Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.20510

7 January 2021

Regional specificity of alterations in NGF, BDNF and NT-3 levels in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.20510

7 January 2021

Cholinergic correlates of cognitive impairment in Parkinson's disease: comparisons with Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.20510

7 January 2021

Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia.

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.20510

7 January 2021

Further analysis of the effects of immunotoxic lesions of the basal nucleus of Meynert reveals substantial impairment on visual discrimination learning in monkeys.

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.20510

7 January 2021

Grafting genetically modified cells to the damaged brain: restorative effects of NGF expression

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.20510

7 January 2021

Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration.

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.20510

7 January 2021

Alzheimer's disease and NGF signaling

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.20510

7 January 2021

Alterations in trk A, trk B and trk C receptor immunoreactivities in parietal cortex and cerebellum in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.20510

7 January 2021

Nerve growth factor in Alzheimer's disease: increased levels throughout the brain coupled with declines in nucleus basalis

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.20510

7 January 2021

Age-associated neuronal atrophy occurs in the primate brain and is reversible by growth factor gene therapy

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.20510

7 January 2021

Atrophy but not death of adult septal cholinergic neurons after ablation of target capacity to produce mRNAs for NGF, BDNF, and NT3

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.20510

7 January 2021

Survival of Adult Basal Forebrain Cholinergic Neurons After Loss of Target Neurons

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.20510

7 January 2021

Nerve growth factor signaling, neuroprotection, and neural repair

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.20510

7 January 2021

Axonopathy and transport deficits early in the pathogenesis of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.20510

7 January 2021

Growth-factor gene therapy for neurodegenerative disorders

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.20510

7 January 2021

Bridging grafts and transient nerve growth factor infusions promote long-term central nervous system neuronal rescue and partial functional recovery

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.20510

7 January 2021

A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.20510

7 January 2021

Nerve growth factor infusion in the primate brain reduces lesion-induced cholinergic neuronal degeneration.

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.20510

7 January 2021

Recombinant human nerve growth factor infusions prevent cholinergic neuronal degeneration in the adult primate brain

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.20510

7 January 2021

Human beta-nerve growth factor gene sequence highly homologous to that of mouse

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.20510

7 January 2021

Gene therapy: twenty-first century medicine

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.20510

7 January 2021

Basal forebrain lesions in monkeys disrupt attention but not learning and memory

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.20510

7 January 2021

The nucleus basalis magnocellularis cholinergic system: one hundred years of progress

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.20510

7 January 2021

Development and regional expression of beta nerve growth factor messenger RNA and protein in the rat central nervous system

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.20510

7 January 2021

Hypophagia is induced by intracerebroventricular administration of nerve growth factor

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.20510

7 January 2021

Continuous infusion of nerve growth factor prevents basal forebrain neuronal death after fimbria fornix transection

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.20510

7 January 2021

Reversible Schwann cell hyperplasia and sprouting of sensory and sympathetic neurites after intraventricular administration of nerve growth factor

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.20510

7 January 2021

Identifiers

DOI

10.1002/DNEU.20510

1 reference

16 August 2017

1 reference

PubMed ID

17514712