Novel yeast-based strategy unveils antagonist binding regions on the nuclear xenobiotic receptor PXR (Q36832670)

16 August 2017

Novel yeast-based strategy unveils antagonist binding regions on the nuclear xenobiotic receptor PXR (English)

1 reference

16 August 2017

2

Matthew R Redinbo

1 reference

16 August 2017

4

Sean Ekins

1 reference

16 August 2017

7

Abdissa Negassa

1 reference

16 August 2017

Hao Li

1

1 reference

16 August 2017

Madhukumar Venkatesh

3

1 reference

16 August 2017

Anik Chaudhry

5

1 reference

16 August 2017

Nicolin Bloch

6

1 reference

16 August 2017

Paromita Mukherjee

8

1 reference

16 August 2017

Ganjam Kalpana

9

1 reference

16 August 2017

Sridhar Mani

10

1 reference

16 August 2017

language of work or name

English

0 references

publication date

22 March 2013

1 reference

Journal of Biological Chemistry

16 August 2017

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16 August 2017

288

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16 August 2017

19

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16 August 2017

13655-13668

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PXR antagonists and implication in drug metabolism

16 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3650402

Pregnane xenobiotic receptor in cancer pathogenesis and therapeutic response

29 September 2017

1 reference

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Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation

29 September 2017

1 reference

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A conserved surface on the ligand binding domain of nuclear receptors for allosteric control

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3650402

In vivo and in vitro characterization of a first-in-class novel azole analog that targets pregnane X receptor activation

29 September 2017

1 reference

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Post-translational modification of pregnane x receptor

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3650402

Acetylation of pregnane X receptor protein determines selective function independent of ligand activation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3650402

Drug discovery and the human kinome: recent trends

29 September 2017

1 reference

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Flavonoids activate pregnane x receptor-mediated CYP3A4 gene expression by inhibiting cyclin-dependent kinases in HepG2 liver carcinoma cells

29 September 2017

1 reference

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Allosteric ligands of the glucagon-like peptide 1 receptor (GLP-1R) differentially modulate endogenous and exogenous peptide responses in a pathway-selective manner: implications for drug screening.

29 September 2017

1 reference

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29 September 2017

1 reference

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29 September 2017

1 reference

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Challenges predicting ligand-receptor interactions of promiscuous proteins: the nuclear receptor PXR

29 September 2017

1 reference

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29 September 2017

1 reference

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29 September 2017

1 reference

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Alternative inhibition of androgen receptor signaling: peptidomimetic pyrimidines as direct androgen receptor/coactivator disruptors

29 September 2017

1 reference

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Elucidating the 'Jekyll and Hyde' nature of PXR: the case for discovering antagonists or allosteric antagonists

29 September 2017

1 reference

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Reverse two-hybrid screening to analyze protein-protein interaction of HIV-1 viral and cellular proteins

29 September 2017

1 reference

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Targeting the androgen receptor pathway in prostate cancer

29 September 2017

1 reference

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Active nuclear receptors exhibit highly correlated AF-2 domain motions

29 September 2017

1 reference

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Synthesis of novel ketoconazole derivatives as inhibitors of the human Pregnane X Receptor (PXR; NR1I2; also termed SXR, PAR).

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3650402

Computational discovery of novel low micromolar human pregnane X receptor antagonists

29 September 2017

1 reference

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A nuclear receptor-like pathway regulating multidrug resistance in fungi

29 September 2017

1 reference

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The phytoestrogen coumestrol is a naturally occurring antagonist of the human pregnane X receptor

29 September 2017

1 reference

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A human immunodeficiency virus protease inhibitor is a novel functional inhibitor of human pregnane X receptor

29 September 2017

1 reference

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One- plus two-hybrid system, a novel yeast genetic selection for specific missense mutations disrupting protein/protein interactions

29 September 2017

1 reference

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Human pregnane X receptor antagonists and agonists define molecular requirements for different binding sites

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3650402

Activated pregnenolone X-receptor is a target for ketoconazole and its analogs.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3650402

Crystal structure of the PXR–T1317 complex provides a scaffold to examine the potential for receptor antagonism

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3650402

Human PXR forms a tryptophan zipper-mediated homodimer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3650402

Structure and function of the human nuclear xenobiotic receptor PXR.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3650402

Targeted gene disruption of the 14-alpha sterol demethylase (cyp51A) in Aspergillus fumigatus and its role in azole drug susceptibility.

29 September 2017

1 reference

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Androgen receptor-cofactor interactions as targets for new drug discovery

29 September 2017

1 reference

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Mechanism of fluconazole resistance in Candida albicans biofilms: phase-specific role of efflux pumps and membrane sterols

29 September 2017

1 reference

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Drug susceptibilities of yeast cells are affected by membrane lipid composition

29 September 2017

1 reference

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Detection of peptides, proteins, and drugs that selectively interact with protein targets

29 September 2017

1 reference

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Putative role of the orphan nuclear receptor SXR (steroid and xenobiotic receptor) in the mechanism of CYP3A4 inhibition by xenobiotics

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3650402

The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux

29 September 2017

1 reference

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Antifungal agents: mode of action, mechanisms of resistance, and correlation of these mechanisms with bacterial resistance

29 September 2017

1 reference

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SXR, a novel steroid and xenobiotic-sensing nuclear receptor

29 September 2017

1 reference

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Clinical, cellular, and molecular factors that contribute to antifungal drug resistance.

29 September 2017

1 reference

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An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway

29 September 2017

1 reference

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Genetic separation of FK506 susceptibility and drug transport in the yeast Pdr5 ATP-binding cassette multidrug resistance transporter.

29 September 2017

1 reference

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29 September 2017

1 reference

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Correlation between rhodamine 123 accumulation and azole sensitivity in Candida species: possible role for drug efflux in drug resistance.

29 September 2017

1 reference

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Deletion of the Candida glabrata ERG3 and ERG11 genes: effect on cell viability, cell growth, sterol composition, and antifungal susceptibility

29 September 2017

1 reference

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29 September 2017

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Mammalian Ras interacts directly with the serine/threonine kinase Raf

29 September 2017

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Genetic analysis of homomeric interactions of human immunodeficiency virus type 1 integrase using the yeast two-hybrid system

29 September 2017

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29 September 2017

1 reference

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The dietary isothiocyanate sulforaphane is an antagonist of the human steroid and xenobiotic nuclear receptor.

5 September 2018

1 reference

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Inhibition of drug metabolism by blocking the activation of nuclear receptors by ketoconazole

5 September 2018

1 reference

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5 September 2018

1 reference

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5 September 2018

1 reference

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The pregnane X receptor regulates gene expression in a ligand- and promoter-selective fashion

5 September 2018

1 reference

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The transmembrane domain 10 of the yeast Pdr5p ABC antifungal efflux pump determines both substrate specificity and inhibitor susceptibility.

5 September 2018

1 reference

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The yeast multidrug resistance pump, Pdr5p, confers reduced drug resistance in erg mutants of Saccharomyces cerevisiae.

5 September 2018

1 reference

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Sterol synthesis and viability of erg11 (cytochrome P450 lanosterol demethylase) mutations in Saccharomyces cerevisiae and Candida albicans

5 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23525103

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M113.455485

1 reference

16 August 2017

1 reference

16 August 2017

PubMed publication ID

23525103

1 reference