Inhibitors of the heat shock response: biology and pharmacology (Q36845355)

16 August 2017

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title

Inhibitors of the heat shock response: biology and pharmacology (English)

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16 August 2017

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2

Paul Workman

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16 August 2017

Marissa V Powers

1

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PubMed ID

17559840

16 August 2017

language of work or name

English

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publication date

25 May 2007

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16 August 2017

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16 August 2017

581

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16 August 2017

19

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16 August 2017

3758-3769

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Pathways of chaperone-mediated protein folding in the cytosol

16 August 2017

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.05.040

Heat shock response modulators as therapeutic tools for diseases of protein conformation

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.05.040

Sick chaperones, cellular stress, and disease

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.05.040

Roles of molecular chaperones in protein misfolding diseases

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.05.040

HSP90 and the chaperoning of cancer

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.05.040

Heat shock proteins in cancer: chaperones of tumorigenesis

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.05.040

Targeting of multiple signalling pathways by heat shock protein 90 molecular chaperone inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.05.040

Approval summary for bortezomib for injection in the treatment of multiple myeloma

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.05.040

Proteasome inhibitors MG132 and lactacystin hyperphosphorylate HSF1 and induce hsp70 and hsp27 expression

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.05.040

Molecular sequelae of proteasome inhibition in human multiple myeloma cells

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.05.040

The anticancer activity of the fungal metabolite terrecyclic acid A is associated with modulation of multiple cellular stress response pathways

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.05.040

The Stress Response: Implications for the Clinical Development of Hsp90 Inhibitors

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.05.040

Gene expression profiling of human colon cancer cells following inhibition of signal transduction by 17-allylamino-17-demethoxygeldanamycin, an inhibitor of the hsp90 molecular chaperone.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.05.040

Up-regulation of heat shock protein 27 induces resistance to 17-allylamino-demethoxygeldanamycin through a glutathione-mediated mechanism

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.05.040

Celastrols as inducers of the heat shock response and cytoprotection.

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.05.040

Celastrol, a triterpene extracted from the Chinese "Thunder of God Vine," is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.05.040

Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.05.040

Pharmacological modulation of heat shock factor 1 by antiinflammatory drugs results in protection against stress-induced cellular damage

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.05.040

Bimoclomol: a nontoxic, hydroxylamine derivative with stress protein-inducing activity and cytoprotective effects

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.05.040

Molecular chaperones and the stress of oncogenesis.

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.05.040

Targeting heat shock response to sensitize cancer cells to proteasome and Hsp90 inhibitors

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.05.040

Targeting the heat shock factor 1 by RNA interference: a potent tool to enhance hyperthermochemotherapy efficacy in cervical cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.05.040

The inhibition of phosphatidylinositol 3-kinase by quercetin and analogs

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.05.040

Abrogation of heat shock protein 70 induction as a strategy to increase antileukemia activity of heat shock protein 90 inhibitor 17-allylamino-demethoxy geldanamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.05.040

Attenuation of chronic thermotolerance by KNK437, a benzylidene lactam compound, enhances thermal radiosensitization in mild temperature hyperthermia combined with low dose-rate irradiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.05.040

Triptolide, an inhibitor of the human heat shock response that enhances stress-induced cell death

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.05.040

PG490 (triptolide) cooperates with tumor necrosis factor-alpha to induce apoptosis in tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.05.040

Effects of the flavonoid drug quercetin on the response of human prostate tumours to hyperthermia in vitro and in vivo

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.05.040

Inhibitors of the HSP90 molecular chaperone: current status

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.05.040

Hsp70 molecular chaperones: emerging roles in human disease and identification of small molecule modulators

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.05.040

Hsp70 chaperones: cellular functions and molecular mechanism

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.05.040

Hsp70 inhibits heat-induced apoptosis upstream of mitochondria by preventing Bax translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.05.040

Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.05.040

Polyglutamine length-dependent interaction of Hsp40 and Hsp70 family chaperones with truncated N-terminal huntingtin: their role in suppression of aggregation and cellular toxicity

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.05.040

Chaperones increase association of tau protein with microtubules

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.05.040

Identification of an inhibitor of hsc70-mediated protein translocation and ATP hydrolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.05.040

Small molecule modulators of endogenous and co-chaperone-stimulated Hsp70 ATPase activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.05.040

Hsp70s contain a specific sulfogalactolipid binding site. Differential aglycone influence on sulfogalactosyl ceramide binding by recombinant prokaryotic and eukaryotic hsp70 family members

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.05.040

Heat Shock Protein 70 Neutralization Exerts Potent Antitumor Effects in Animal Models of Colon Cancer and Melanoma

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.05.040

Hsp90 isoforms: functions, expression and clinical importance

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.05.040

The role of Hsp90N, a new member of the Hsp90 family, in signal transduction and neoplastic transformation

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.05.040

Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.05.040

Interaction of radicicol with members of the heat shock protein 90 family of molecular chaperones

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.05.040

Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.05.040

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.05.040

DT-Diaphorase expression and tumor cell sensitivity to 17-allylamino, 17-demethoxygeldanamycin, an inhibitor of heat shock protein 90

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.05.040

Pharmacokinetic-pharmacodynamic relationships for the heat shock protein 90 molecular chaperone inhibitor 17-allylamino, 17-demethoxygeldanamycin in human ovarian cancer xenograft models

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.05.040

A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.05.040

Phase I pharmacokinetic and pharmacodynamic study of 17-allylamino, 17-demethoxygeldanamycin in patients with advanced malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.05.040

Formation of 17-allylamino-demethoxygeldanamycin (17-AAG) hydroquinone by NAD(P)H:quinone oxidoreductase 1: role of 17-AAG hydroquinone in heat shock protein 90 inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.05.040

Development of 17-allylamino-17-demethoxygeldanamycin hydroquinone hydrochloride (IPI-504), an anti-cancer agent directed against Hsp90.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.05.040

The identification, synthesis, protein crystal structure and in vitro biochemical evaluation of a new 3,4-diarylpyrazole class of Hsp90 inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.05.040

Novel, potent small-molecule inhibitors of the molecular chaperone Hsp90 discovered through structure-based design

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.05.040

Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.05.040

A small molecule designed to bind to the adenine nucleotide pocket of Hsp90 causes Her2 degradation and the growth arrest and differentiation of breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.05.040

Targeting wide-range oncogenic transformation via PU24FCl, a specific inhibitor of tumor Hsp90.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.05.040

Identification of potent water soluble purine-scaffold inhibitors of the heat shock protein 90.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.05.040

The heat shock protein 90 antagonist novobiocin interacts with a previously unrecognized ATP-binding domain in the carboxyl terminus of the chaperone

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.05.040

The C-terminal half of heat shock protein 90 represents a second site for pharmacologic intervention in chaperone function

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.05.040

Hsp90 inhibitors identified from a library of novobiocin analogues

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.05.040

Rational design of shepherdin, a novel anticancer agent.

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.05.040

Antileukemic activity of shepherdin and molecular diversity of hsp90 inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.05.040

Structure of the N-terminal domain of GRP94. Basis for ligand specificity and regulation

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.05.040

Hsp90: the vulnerable chaperone

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.05.040

An acetylation site in the middle domain of Hsp90 regulates chaperone function

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.05.040

Histone modification enzymes: novel targets for cancer drugs

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.05.040

Recombinant antibodies: a natural partner in combinatorial antifungal therapy

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.05.040

Activation of the ATPase activity of hsp90 by the stress-regulated cochaperone aha1

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.05.040

Aha1 competes with Hop, p50 and p23 for binding to the molecular chaperone Hsp90 and contributes to kinase and hormone receptor activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.05.040

Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.05.040

Structure and mechanism of the Hsp90 molecular chaperone machinery

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.05.040

Small-Molecule Targeting of Heat Shock Protein 90 Chaperone Function: Rational Identification of a New Anticancer Lead

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.05.040

In vitro Biological Characterization of a Novel, Synthetic Diaryl Pyrazole Resorcinol Class of Heat Shock Protein 90 Inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.05.040

A New Antifungal Substance of Fungal Origin

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.05.040

10.1016/J.FEBSLET.2007.05.040

21 January 2018

Identifiers

DOI

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16 August 2017

1 reference

PubMed ID

17559840