Hsp70 inhibits heat-induced apoptosis upstream of mitochondria by preventing Bax translocation (Q40371434)

19 September 2017

Hsp70 inhibits heat-induced apoptosis upstream of mitochondria by preventing Bax translocation (English)

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19 September 2017

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Adam R Stankiewicz

1

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19 September 2017

Guillaume Lachapelle

2

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19 September 2017

Cheryl P Z Foo

3

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19 September 2017

Stefanie M Radicioni

4

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19 September 2017

Dick D Mosser

5

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19 September 2017

language of work or name

English

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publication date

19 September 2005

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Journal of Biological Chemistry

19 September 2017

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19 September 2017

280

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19 September 2017

38729-38739

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19 September 2017

46

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Ways of dying: multiple pathways to apoptosis.

19 September 2017

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https://api.crossref.org/works/10.1074%2FJBC.M509497200

Cell death: critical control points

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M509497200

Molecular mechanisms of caspase regulation during apoptosis

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M509497200

Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M509497200

The pathophysiology of mitochondrial cell death

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M509497200

The Bcl-2 family: roles in cell survival and oncogenesis.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M509497200

BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M509497200

Bax oligomerization is required for channel-forming activity in liposomes and to trigger cytochrome c release from mitochondria

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M509497200

Regulated targeting of BAX to mitochondria.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M509497200

Conformation of the Bax C-terminus regulates subcellular location and cell death

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M509497200

Movement of Bax from the cytosol to mitochondria during apoptosis

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M509497200

Pathways of chaperone-mediated protein folding in the cytosol

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M509497200

Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M509497200

Induced thermal resistance in HeLa cells

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M509497200

Induced thermotolerance to apoptosis in a human T lymphocyte cell line

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M509497200

21 January 2018

The Hallmarks of Cancer

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https://api.crossref.org/works/10.1074%2FJBC.M509497200

Death and anti-death: tumour resistance to apoptosis

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M509497200

Escaping cell death: survival proteins in cancer

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M509497200

Molecular chaperones and the stress of oncogenesis.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M509497200

Heat shock protein 90 as a molecular target for cancer therapeutics

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M509497200

Role of the human heat shock protein hsp70 in protection against stress-induced apoptosis

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M509497200

The chaperone function of hsp70 is required for protection against stress-induced apoptosis

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M509497200

Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M509497200

Negative regulation of the Apaf-1 apoptosome by Hsp70

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M509497200

Heat shock protein 72 modulates pathways of stress-induced apoptosis.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M509497200

Heat shock protein 70 promotes cell survival by inhibiting lysosomal membrane permeabilization

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M509497200

Heat-shock protein 70 antagonizes apoptosis-inducing factor

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M509497200

Hsp70 exerts its anti-apoptotic function downstream of caspase-3-like proteases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509497200

Hsp72 inhibits apoptosis upstream of the mitochondria and not through interactions with Apaf-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509497200

Transcription factor ATF2 regulation by the JNK signal transduction pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509497200

Conserved features of eukaryotic hsp70 genes revealed by comparison with the nucleotide sequence of human hsp70

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509497200

Direct activation of the apoptosis machinery as a mechanism to target cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509497200

Bcl-2 prevents Bax oligomerization in the mitochondrial outer membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509497200

Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509497200

Bax is present as a high molecular weight oligomer/complex in the mitochondrial membrane of apoptotic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509497200

Invited review: Interplay between molecular chaperones and signaling pathways in survival of heat shock

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509497200

Stress management - heat shock protein-70 and the regulation of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509497200

SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509497200

Structure of Bax: coregulation of dimer formation and intracellular localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509497200

hsp70-DnaJ chaperone pair prevents nitric oxide- and CHOP-induced apoptosis by inhibiting translocation of Bax to mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509497200

Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509497200

The Bax subfamily of Bcl2-related proteins is essential for apoptotic signal transduction by c-Jun NH(2)-terminal kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509497200

JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M509497200

JNK-mediated BIM phosphorylation potentiates BAX-dependent apoptosis

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M509497200

JNK promotes Bax translocation to mitochondria through phosphorylation of 14-3-3 proteins

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M509497200

BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509497200

JNK suppresses apoptosis via phosphorylation of the proapoptotic Bcl-2 family protein BAD

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509497200

Survival factor-induced extracellular signal-regulated kinase phosphorylates BIM, inhibiting its association with BAX and proapoptotic activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509497200

Inactivation of Dual-Specificity Phosphatases Is Involved in the Regulation of Extracellular Signal-Regulated Kinases by Heat Shock and Hsp72

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509497200

Preheating accelerates mitogen-activated protein (MAP) kinase inactivation post-heat shock via a heat shock protein 70-mediated increase in phosphorylated MAP kinase phosphatase-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509497200

Requirement for ERK activation in cisplatin-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509497200

Selective depletion of heat shock protein 70 (Hsp70) activates a tumor-specific death program that is independent of caspases and bypasses Bcl-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509497200

Members of the heat-shock protein 70 family promote cancer cell growth by distinct mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509497200

Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509497200

Apaf-1 and caspase-9 do not act as tumor suppressors in myc-induced lymphomagenesis or mouse embryo fibroblast transformation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509497200

Bax suppresses tumorigenesis and stimulates apoptosis in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509497200

Increased expression of the major heat shock protein Hsp72 in human prostate carcinoma cells is dispensable for their viability but confers resistance to a variety of anticancer agents.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509497200

"The stress of dying": the role of heat shock proteins in the regulation of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509497200

21 January 2018

Identifiers

DOI

10.1074/JBC.M509497200

1 reference

19 September 2017

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