Structure and function of the atypical orphan nuclear receptor small heterodimer partner (Q36845708)

16 August 2017

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title

Structure and function of the atypical orphan nuclear receptor small heterodimer partner (English)

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16 August 2017

Yong-Soo Lee

1

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16 August 2017

Dipanjan Chanda

2

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16 August 2017

Jeonggu Sim

3

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16 August 2017

Yun-Yong Park

4

1 reference

16 August 2017

Hueng-Sik Choi

5

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16 August 2017

1 January 2007

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International Review of Cytology

16 August 2017

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16 August 2017

261

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16 August 2017

117-158

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Nuclear hormone receptors and gene expression

16 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

Repression of CAR-mediated transactivation of CYP2B genes by the orphan nuclear receptor, short heterodimer partner (SHP).

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

A transcriptional inhibitor targeted by the atypical orphan nuclear receptor SHP

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

Glucocorticoid signaling is perturbed by the atypical orphan receptor and corepressor SHP

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

Functional role of G9a-induced histone methylation in small heterodimer partner-mediated transcriptional repression

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

Regulation of hepatic metabolic pathways by the orphan nuclear receptor SHP.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

The small heterodimer partner interacts with the liver X receptor alpha and represses its transcriptional activity

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

Identification of polymorphisms in the human SHP1 gene

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

Nuclear receptors and lipid physiology: opening the X-files

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

Liver receptor homologue-1 mediates species- and cell line-specific bile acid-dependent negative feedback regulation of the apical sodium-dependent bile acid transporter

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

The orphan nuclear receptor SHP is involved in monocytic differentiation, and its expression is increased by c-Jun

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

Guggulsterone is a farnesoid X receptor antagonist in coactivator association assays but acts to enhance transcription of bile salt export pump

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase promoter by nuclear receptors liver receptor homologue-1 and small heterodimer partner: a mechanism for differential regulation of cholesterol synthesis and uptake

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

Grape seed procyanidins improve atherosclerotic risk index and induce liver CYP7A1 and SHP expression in healthy rats

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

The role of alpha1-fetoprotein transcription factor/LRH-1 in bile acid biosynthesis: a known nuclear receptor activator that can act as a suppressor of bile acid biosynthesis

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

Identification of liver receptor homolog-1 as a novel regulator of apolipoprotein AI gene transcription

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

Mutation analysis of NR0B2 among 1545 Danish men identifies a novel c.278G>A (p.G93D) variant with reduced functional activity

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

Feedback regulation of bile acid synthesis in primary human hepatocytes: evidence that CDCA is the strongest inhibitor

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

Estrogen receptor alpha inhibits IL-1beta induction of gene expression in the mouse liver

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

The nuclear receptor SHP mediates inhibition of hepatic stellate cells by FXR and protects against liver fibrosis

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

Hepatocyte nuclear factor-4alpha plays pivotal roles in the regulation of mouse carboxylesterase 2 gene transcription in mouse liver

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

Orphan nuclear receptors: from gene to function

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

Characterization of the interaction between androgen receptor and a new transcriptional inhibitor, SHP.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

SHP represses transcriptional activity via recruitment of histone deacetylases.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

Differential regulation of rat and human CYP7A1 by the nuclear oxysterol receptor liver X receptor-alpha

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

Down-regulation of cholesterol 7alpha-hydroxylase (CYP7A1) gene expression by bile acids in primary rat hepatocytes is mediated by the c-Jun N-terminal kinase pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

Bile acid reduces the secretion of very low density lipoprotein by repressing microsomal triglyceride transfer protein gene expression mediated by hepatocyte nuclear factor-4.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

Contribution of variants in the small heterodimer partner gene to birthweight, adiposity, and insulin levels: mutational analysis and association studies in multiple populations

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

Deficiency of interleukin-1 receptor antagonist deteriorates fatty liver and cholesterol metabolism in hypercholesterolemic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

Impaired negative feedback suppression of bile acid synthesis in mice lacking betaKlotho

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

Dosage-sensitive sex reversal adrenal hypoplasia congenita critical region on the X chromosome, gene 1 (DAX1) (NR0B1) and small heterodimer partner (SHP) (NR0B2) form homodimers individually, as well as DAX1-SHP heterodimers

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

Cytokine regulation of human sterol 12alpha-hydroxylase (CYP8B1) gene.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

The orphan nuclear receptor SHP inhibits agonist-dependent transcriptional activity of estrogen receptors ERalpha and ERbeta

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

The orphan nuclear receptor SHP utilizes conserved LXXLL-related motifs for interactions with ligand-activated estrogen receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

Hepatocyte nuclear factor 1 alpha: a key mediator of the effect of bile acids on gene expression

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

Role of liver-enriched transcription factors and nuclear receptors in regulating the human, mouse, and rat NTCP gene

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

The nuclear bile acid receptor FXR is activated by PGC-1alpha in a ligand-dependent manner

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

The short heterodimer partner receptor differentially modulates peroxisome proliferator-activated receptor alpha-mediated transcription from the peroxisome proliferator-response elements of the genes encoding the peroxisomal beta-oxidation enzymes a

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

Role of an mSin3A-Swi/Snf chromatin remodeling complex in the feedback repression of bile acid biosynthesis by SHP.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

Loss of nuclear receptor SHP impairs but does not eliminate negative feedback regulation of bile acid synthesis

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

Synergistic activation of the human orphan nuclear receptor SHP gene promoter by basic helix-loop-helix protein E2A and orphan nuclear receptor SF-1

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

Differential regulation of human and mouse orphan nuclear receptor small heterodimer partner promoter by sterol regulatory element binding protein-1.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

Orphan nuclear receptor small heterodimer partner represses hepatocyte nuclear factor 3/Foxa transactivation via inhibition of its DNA binding

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

Orphan nuclear receptor small heterodimer partner, a novel corepressor for a basic helix-loop-helix transcription factor BETA2/neuroD

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

The orphan nuclear receptor small heterodimer partner as a novel coregulator of nuclear factor-kappa b in oxidized low density lipoprotein-treated macrophage cell line RAW 264.7.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

Short heterodimer partner (SHP) orphan nuclear receptor inhibits the transcriptional activity of aryl hydrocarbon receptor (AHR)/AHR nuclear translocator (ARNT).

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

The Agonist Activity of Tamoxifen Is Inhibited by the Short Heterodimer Partner Orphan Nuclear Receptor in Human Endometrial Cancer Cells

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

Enterohepatic bile salt transporters in normal physiology and liver disease

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

Estrogen receptor alpha regulates expression of the orphan receptor small heterodimer partner

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

Structure and expression of the orphan nuclear receptor SHP gene

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

Dual mechanisms for repression of the monomeric orphan receptor liver receptor homologous protein-1 by the orphan small heterodimer partner

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

Activation of the promoter of the orphan receptor SHP by orphan receptors that bind DNA as monomers

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

The orphan nuclear receptor SHP inhibits hepatocyte nuclear factor 4 and retinoid X receptor transactivation: two mechanisms for repression

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

Phosphorylation of the hinge domain of the nuclear hormone receptor LRH-1 stimulates transactivation

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

FXR-activating ligands inhibit rabbit ASBT expression via FXR-SHP-FTF cascade

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

Structural and biochemical basis for selective repression of the orphan nuclear receptor liver receptor homolog 1 by small heterodimer partner

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

Farnesoid X receptor is essential for normal glucose homeostasis

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

Unveiling hidden features of orphan nuclear receptors: the case of the small heterodimer partner (SHP).

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

Bile acids reduce SR-BI expression in hepatocytes by a pathway involving FXR/RXR, SHP, and LRH-1.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

An orphan nuclear receptor lacking a zinc-finger DNA-binding domain: interaction with several nuclear receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

Genetic Variation in the Small Heterodimer Partner Gene and Young-Onset Type 2 Diabetes, Obesity, and Birth Weight in U.K. Subjects

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

Bile acid-induced negative feedback regulation of the human ileal bile acid transporter

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

Mutations in the small heterodimer partner gene are associated with mild obesity in Japanese subjects

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

Identification of intermediates in the bile acid synthetic pathway as ligands for the farnesoid X receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

Small heterodimer partner, an orphan nuclear receptor, augments peroxisome proliferator-activated receptor gamma transactivation

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

Nuclear translocation of SHP and visualization of interaction with HNF-4alpha in living cells

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHP

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

The small heterodimer partner interacts with the pregnane X receptor and represses its transcriptional activity.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

Glucotoxicity in the INS-1 rat insulinoma cell line is mediated by the orphan nuclear receptor small heterodimer partner

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

Differential role of the loop region between helices H6 and H7 within the orphan nuclear receptors small heterodimer partner and DAX-1.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

An autoregulatory loop controlling orphan nuclear receptor DAX-1 gene expression by orphan nuclear receptor ERRgamma

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

Bile acids: natural ligands for an orphan nuclear receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

The human organic anion transporter 2 gene is transactivated by hepatocyte nuclear factor-4 alpha and suppressed by bile acids.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

The methyl transferase PRMT1 functions as co-activator of farnesoid X receptor (FXR)/9-cis retinoid X receptor and regulates transcription of FXR responsive genes

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

How many nuclear hormone receptors are there in the human genome?

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

The human organic cation transporter-1 gene is transactivated by hepatocyte nuclear factor-4alpha

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

Differential regulation of the orphan nuclear receptor small heterodimer partner (SHP) gene promoter by orphan nuclear receptor ERR isoforms

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

An orphan nuclear hormone receptor that lacks a DNA binding domain and heterodimerizes with other receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

Novel receptor interaction and repression domains in the orphan receptor SHP.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

Inhibition of Estrogen Receptor Action by the Orphan Receptor SHP (Short Heterodimer Partner)

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

Hepatocyte nuclear factor-1alpha is an essential regulator of bile acid and plasma cholesterol metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

Loss of HNF-1alpha function in mice leads to abnormal expression of genes involved in pancreatic islet development and metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

Inhibitory effect of the small heterodimer partner on hepatocyte nuclear factor-4 mediates bile acid-induced repression of the human angiotensinogen gene

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

The atypical orphan nuclear receptor DAX-1 interacts with orphan nuclear receptor Nur77 and represses its transactivation

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

Orphan nuclear receptor small heterodimer partner inhibits transforming growth factor-beta signaling by repressing SMAD3 transactivation.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

Overexpression of short heterodimer partner recovers impaired glucose-stimulated insulin secretion of pancreatic beta-cells overexpressing UCP2.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

Molecular cloning of DAX1 and SHP cDNAs and their expression patterns in the Nile tilapia, Oreochromis niloticus

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

Redundant pathways for negative feedback regulation of bile acid production

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

Resistance of SHP-null mice to bile acid-induced liver damage

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

The orphan nuclear receptor SHP regulates PGC-1alpha expression and energy production in brown adipocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

Orphan receptor small heterodimer partner is an important mediator of glucose homeostasis

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

Bile acids regulate gluconeogenic gene expression via small heterodimer partner-mediated repression of hepatocyte nuclear factor 4 and Foxo1.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

Nuclear receptor expression links the circadian clock to metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

On the mechanism of bile acid inhibition of rat sterol 12α-hydroxylase gene (CYP8B1) transcription: roles of α-fetoprotein transcription factor and hepatocyte nuclear factor 4α

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

Negative cross-talk between Nur77 and small heterodimer partner and its role in apoptotic cell death of hepatoma cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

An unusual member of the nuclear hormone receptor superfamily responsible for X-linked adrenal hypoplasia congenita

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

Transcriptional regulation of the human sterol 12alpha-hydroxylase gene (CYP8B1): roles of heaptocyte nuclear factor 4alpha in mediating bile acid repression

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

Induction of short heterodimer partner 1 precedes downregulation of Ntcp in bile duct-ligated mice

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

10.1016/S0074-7696(07)61003-1

Identifiers

DOI

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16 August 2017

1 reference