Nox4 NAD(P)H oxidase mediates Src-dependent tyrosine phosphorylation of PDK-1 in response to angiotensin II: role in mesangial cell hypertrophy and fibronectin expression (Q36855830)

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scientific article published on 16 June 2008

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English	Nox4 NAD(P)H oxidase mediates Src-dependent tyrosine phosphorylation of PDK-1 in response to angiotensin II: role in mesangial cell hypertrophy and fibronectin expression	scientific article published on 16 June 2008

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scholarly article

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Europe PubMed Central

PMC publication ID

16 August 2017

Nox4 NAD(P)H oxidase mediates Src-dependent tyrosine phosphorylation of PDK-1 in response to angiotensin II: role in mesangial cell hypertrophy and fibronectin expression (English)

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

phosphorylation

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based on heuristic

inferred from title

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based on heuristic

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object named as

Yves Gorin

6

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Kathy K. Griendling

object named as

Kathy K Griendling

3

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author name string

Karen Block

1

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Europe PubMed Central

PMC publication ID

16 August 2017

Assaad Eid

2

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Europe PubMed Central

PMC publication ID

16 August 2017

Duck-Yoon Lee

4

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Europe PubMed Central

PMC publication ID

16 August 2017

Yohann Wittrant

5

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Europe PubMed Central

PMC publication ID

16 August 2017

language of work or name

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publication date

16 June 2008

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Europe PubMed Central

PMC publication ID

16 August 2017

Journal of Biological Chemistry

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Europe PubMed Central

PMC publication ID

16 August 2017

283

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Europe PubMed Central

PMC publication ID

16 August 2017

35

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

24061-24076

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

describes a project that uses

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Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2527116/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Regulation of 3-phosphoinositide-dependent protein kinase-1 (PDK1) by Src involves tyrosine phosphorylation of PDK1 and Src homology 2 domain binding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2527116

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Nox enzymes, ROS, and chronic disease: an example of antagonistic pleiotropy

1 reference

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29 September 2017

A novel phosphoinositide 3-kinase-dependent pathway for angiotensin II/AT-1 receptor-mediated induction of collagen synthesis in MES-13 mesangial cells

1 reference

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29 September 2017

The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology

1 reference

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29 September 2017

NADPH oxidases in the kidney

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2527116

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Renal injury due to renin-angiotensin-aldosterone system activation of the transforming growth factor-beta pathway

1 reference

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29 September 2017

Mesangial cell hypertrophy by high glucose is mediated by downregulation of the tumor suppressor PTEN

1 reference

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29 September 2017

Angiotensin II-dependent Src and Smad1 signaling pathway is crucial for the development of diabetic nephropathy

1 reference

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29 September 2017

NADPH oxidases: new kids on the block

1 reference

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29 September 2017

Tyrosine phosphorylation of phosphoinositide-dependent kinase 1 by the insulin receptor is necessary for insulin metabolic signaling

1 reference

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29 September 2017

Angiotensin II: a key factor in the inflammatory and fibrotic response in kidney diseases

1 reference

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29 September 2017

Mesangial cells and glomerular inflammation: from the pathogenesis to novel therapeutic approaches

1 reference

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29 September 2017

Cellular and molecular pathways that lead to progression and regression of renal fibrogenesis.

1 reference

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29 September 2017

Intracellular reactive oxygen species activate Src tyrosine kinase during cell adhesion and anchorage-dependent cell growth

1 reference

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Insights into the mechanisms of renal fibrosis: is it possible to achieve regression?

1 reference

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Pathogenetic mechanisms of diabetic nephropathy

1 reference

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29 September 2017

Functional analysis of Nox4 reveals unique characteristics compared to other NADPH oxidases

1 reference

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PDK1 nucleates T cell receptor-induced signaling complex for NF-kappaB activation

1 reference

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29 September 2017

Direct interaction of the novel Nox proteins with p22phox is required for the formation of a functionally active NADPH oxidase

1 reference

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29 September 2017

Reactive oxygen species and angiotensin II signaling in vascular cells -- implications in cardiovascular disease

1 reference

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Advances in protein kinase B signalling: AKTion on multiple fronts

1 reference

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Sphingosine 1-phosphate transactivates the platelet-derived growth factor beta receptor and epidermal growth factor receptor in vascular smooth muscle cells

1 reference

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Angiotensin II-induced ERK1/ERK2 activation and protein synthesis are redox-dependent in glomerular mesangial cells

1 reference

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Pyk2- and Src-dependent tyrosine phosphorylation of PDK1 regulates focal adhesions

1 reference

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Effect of hyperglycemia on signal transduction in skeletal muscle from diabetic Goto-Kakizaki rats

1 reference

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29 September 2017

The renin-angiotensin-aldosterone system: cardiorenal effects and implications for renal and cardiovascular disease states

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2527116

29 September 2017

Vascular NAD(P)H oxidases: specific features, expression, and regulation

1 reference

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29 September 2017

Nox4 mediates angiotensin II-induced activation of Akt/protein kinase B in mesangial cells

1 reference

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29 September 2017

NAD(P)H oxidase-derived reactive oxygen species as mediators of angiotensin II signaling

1 reference

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Remission of renal disease: recounting the challenge, acquiring the goal

1 reference

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Angiotensin II and growth factors in the pathogenesis of diabetic nephropathy

1 reference

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Redox-linked signal transduction pathways for protein tyrosine kinase activation

1 reference

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Oxidative stress and vanadate induce tyrosine phosphorylation of phosphoinositide-dependent kinase 1 (PDK1).

1 reference

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Molecular and cellular mechanisms of angiotensin II-mediated cardiovascular and renal diseases

1 reference

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The PI3K-PDK1 connection: more than just a road to PKB

1 reference

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Phosphorylation of Ser-241 is essential for the activity of 3-phosphoinositide-dependent protein kinase-1: identification of five sites of phosphorylation in vivo

1 reference

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Molecular mechanisms of diabetic renal hypertrophy

1 reference

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ACE-I vs angiotensin II receptor antagonists: prevention of renal injury in chronic rat models

1 reference

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Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

1 reference

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1 reference

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NAD(P)H oxidases regulate HIF-2alpha protein expression.

1 reference

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4 September 2018

Nox4 NAD(P)H oxidase mediates hypertrophy and fibronectin expression in the diabetic kidney

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2527116

4 September 2018

Mesangial cell NADPH oxidase upregulation in high glucose is protein kinase C dependent and required for collagen IV expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2527116

4 September 2018

Mechanisms of reactive oxygen species-dependent downregulation of insulin receptor substrate-1 by angiotensin II.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2527116

4 September 2018

Phosphoinositide-dependent kinase 1 and p21-activated protein kinase mediate reactive oxygen species-dependent regulation of platelet-derived growth factor-induced smooth muscle cell migration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2527116

4 September 2018

Involvement of calcineurin in transforming growth factor-beta-mediated regulation of extracellular matrix accumulation

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2527116

4 September 2018

The Phosphatidylinositol 3-Kinase/Akt Pathway Enhances Smad3-stimulated Mesangial Cell Collagen I Expression in Response to Transforming Growth Factor-β1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2527116

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RET/PTC (rearranged in transformation/papillary thyroid carcinomas) tyrosine kinase phosphorylates and activates phosphoinositide-dependent kinase 1 (PDK1): an alternative phosphatidylinositol 3-kinase-independent pathway to activate PDK1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2527116

4 September 2018

Insulin stimulates increased catalytic activity of phosphoinositide-dependent kinase-1 by a phosphorylation-dependent mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2527116

4 September 2018

Angiotensin II activates Akt/protein kinase B by an arachidonic acid/redox-dependent pathway and independent of phosphoinositide 3-kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2527116

4 September 2018

Identification of tyrosine phosphorylation sites on 3-phosphoinositide-dependent protein kinase-1 and their role in regulating kinase activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2527116

4 September 2018

Epidermal growth factor receptor transactivation by angiotensin II requires reactive oxygen species in vascular smooth muscle cells.

1 reference

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5-Hydroxytryptamine1A receptor/Gibetagamma stimulates mitogen-activated protein kinase via NAD(P)H oxidase and reactive oxygen species upstream of src in chinese hamster ovary fibroblasts

1 reference

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Novel sources of reactive oxygen species in the human body

1 reference

https://pubmed.ncbi.nlm.nih.gov/18559349

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peroxovanadate induces tyrosine phosphorylation of phosphoinositide-dependent protein kinase-1

1 reference

https://pubmed.ncbi.nlm.nih.gov/18559349

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Collagen I induction by high glucose levels is mediated by epidermal growth factor receptor and phosphoinositide 3-kinase/Akt signalling in mesangial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18559349

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of angiotensin II receptors and PKC isoforms by glucose in rat mesangial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18559349

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Arachidonic acid-dependent activation of a p22(phox)-based NAD(P)H oxidase mediates angiotensin II-induced mesangial cell protein synthesis and fibronectin expression via Akt/PKB

1 reference

https://pubmed.ncbi.nlm.nih.gov/18559349

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alpha1-adrenergic receptors activate AKT via a Pyk2/PDK-1 pathway that is tonically inhibited by novel protein kinase C isoforms in cardiomyocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/18559349

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High glucose, high insulin, and their combination rapidly induce laminin-beta1 synthesis by regulation of mRNA translation in renal epithelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18559349

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M803964200

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

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