Rational design, synthesis, and evaluation of key analogues of CC-1065 and the duocarmycins (Q36865765)

16 August 2017

Rational design, synthesis, and evaluation of key analogues of CC-1065 and the duocarmycins (English)

1 reference

16 August 2017

Mark S Tichenor

1

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16 August 2017

Karen S MacMillan

2

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16 August 2017

James S Stover

3

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16 August 2017

Scott E Wolkenberg

4

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16 August 2017

Maria G Pavani

5

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16 August 2017

Lorenzo Zanella

6

1 reference

16 August 2017

Abdel N Zaid

7

1 reference

16 August 2017

Gianpiero Spalluto

8

1 reference

16 August 2017

Thomas J Rayl

9

1 reference

16 August 2017

Inkyu Hwang

10

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16 August 2017

Pier Giovanni Baraldi

11

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16 August 2017

Dale L Boger

12

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16 August 2017

language of work or name

English

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publication date

19 October 2007

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Journal of the American Chemical Society

16 August 2017

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16 August 2017

129

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16 August 2017

45

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16 August 2017

14092-14099

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Systematic exploration of the structural features of yatakemycin impacting DNA alkylation and biological activity

16 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2531197

Asymmetric total synthesis of (+)- and ent-(-)-yatakemycin and duocarmycin SA: evaluation of yatakemycin key partial structures and its unnatural enantiomer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2531197

Sequence-selective DNA recognition: natural products and nature's lessons

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2531197

Synthesis and evaluation of N-aryl and N-alkenyl CBI derivatives.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2531197

Mechanisms of in situ activation for DNA-targeting antitumor agents

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2531197

CC-1065 and the duocarmycins: unraveling the keys to a new class of naturally derived DNA alkylating agents

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2531197

Duocarmycin A, a new antitumor antibiotic from Streptomyces

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2531197

A demonstration of the intrinsic importance of stabilizing hydrophobic binding and non-covalent van der Waals contacts dominant in the non-covalent CC-1065/B-DNA binding

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2531197

Demonstration of a pronounced effect of noncovalent binding selectivity on the (+)-CC-1065 DNA alkylation and identification of the pharmacophore of the alkylation subunit

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2531197

Stereoelectronic factors influencing the biological activity and DNA interaction of synthetic antitumor agents modeled on CC-1065.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2531197

Adozelesin, a selected lead among cyclopropylpyrroloindole analogs of the DNA-binding antibiotic, CC-1065.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2531197

Alkylation of duplex DNA in nucleosome core particles by duocarmycin SA and yatakemycin

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2531197

Establishing the parabolic relationship between reactivity and activity for derivatives and analogues of the duocarmycin and CC-1065 alkylation subunits

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2531197

DNA alkylation properties of yatakemycin

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2531197

Yatakemycin, a novel antifungal antibiotic produced by Streptomyces sp. TP-A0356.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2531197

Synthesis and Properties of Substituted CBI Analogs of CC-1065 and the Duocarmycins Incorporating the 7-Methoxy-1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-one (MCBI) Alkylation Subunit: Magnitude of Electronic Effects on the Functional Reactivit

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2531197

Molecular basis for sequence selective DNA alkylation by (+)- and ent-(-)-CC-1065 and related agents: alkylation site models that accommodate the offset AT-rich adenine N3 alkylation selectivity

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2531197

Preparation of benzene, furan, and thiophene analogs of duocarmycin SA employing a newly-devised phenol-forming reaction

4 September 2018

1 reference

12 December 2020

CC-1065 and the Duocarmycins: Synthetic Studies

1 reference

12 December 2020

Duocarmycin SA, a new antitumor antibiotic from Streptomyces sp

1 reference

12 December 2020

An alternative and convenient strategy for generation of substantial quantities of singly 5'-32P-end-labeled double-stranded DNA for binding studies: development of a protocol for examination of functional features of (+)-CC-1065 and the duocarmycin

1 reference

12 December 2020

Molecular basis for sequence-specific DNA alkylation by CC-1065

1 reference

12 December 2020

CC-1065 (NSC 298223), a potent new antitumor agent improved production and isolation, characterization and antitumor activity

1 reference

12 December 2020

Synthesis and biochemical evaluation of the CBI-PDE-I-dimer, a benzannelated analog of (+)-CC-1065 that also produces delayed toxicity in mice

1 reference

12 December 2020

1,2,9,9a-Tetrahydrocyclopropa[c]benz[e]indol-4-one (CBI) analogs of CC-1065 and the duocarmycins: synthesis and evaluation

1 reference

12 December 2020

Catalysis of the CC-1065 and duocarmycin DNA alkylation reaction: DNA binding induced conformational change in the agent results in activation

1 reference

12 December 2020

Yatakemycin, a Novel Antifungal Antibiotic Produced by Streptomyces sp. TP-A0356.

1 reference

COCI

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.56.107

Duocarmycin A, a new antitumor antibiotic from Streptomyces.

12 April 2024

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.41.1915

Identifiers

DOI

10.1021/JA073989Z

1 reference

16 August 2017

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16 August 2017

PubMed publication ID

17948994

1 reference