Molecular mechanisms of CD4+ T-cell anergy (Q36870857)

16 August 2017

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title

Molecular mechanisms of CD4+ T-cell anergy (English)

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16 August 2017

C Garrison Fathman

1

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16 August 2017

Neil B Lineberry

series ordinal

2

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16 August 2017

publication date

6 July 2007

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Nature Reviews Immunology

16 August 2017

published in

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16 August 2017

volume

7

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16 August 2017

issue

8

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16 August 2017

page(s)

599-609

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Regulation of immunity by self-reactive T cells

16 August 2017

cites work

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Pathways of apoptosis in lymphocyte development, homeostasis, and disease

31 March 2020

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Positive and negative selection of T cells

31 March 2020

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T-cell unresponsiveness in vivo and in vitro: fine specificity of induction and molecular characterization of the unresponsive state

31 March 2020

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31 March 2020

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Molecular events in the induction of a nonresponsive state in interleukin 2-producing helper T-lymphocyte clones

31 March 2020

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Reversal of in vitro T cell clonal anergy by IL-2 stimulation

31 March 2020

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Transactivation by AP-1 is a molecular target of T cell clonal anergy

31 March 2020

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Blocked Ras activation in anergic CD4+ T cells

31 March 2020

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Blocked Signal Transduction to the ERK and JNK Protein Kinases in Anergic CD4+ T Cells

31 March 2020

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Anergic T cells are defective in both jun NH2-terminal kinase and mitogen-activated protein kinase signaling pathways

31 March 2020

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Expression of NFAT-family proteins in normal human T cells

31 March 2020

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Immobilized anti-CD3 mAb induces anergy in murine naive and memory CD4+ T cells in vitro.

31 March 2020

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JNK is involved in signal integration during costimulation of T lymphocytes.

31 March 2020

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A nondeletional mechanism of thymic self tolerance

31 March 2020

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In vivo induction of anergy in peripheral V beta 8+ T cells by staphylococcal enterotoxin B.

31 March 2020

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Selective anergy of V beta 8+,CD4+ T cells in Staphylococcus enterotoxin B-primed mice

31 March 2020

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Conditions that induce tolerance in mature CD4+ T cells

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Clonal anergy blocks in vivo growth of mature T cells and can be reversed in the absence of antigen

31 March 2020

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Anergy and exhaustion are independent mechanisms of peripheral T cell tolerance

31 March 2020

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Induction of T cell anergy in the absence of CTLA-4/B7 interaction

31 March 2020

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Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement.

31 March 2020

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Stimulation of p21 ras upon T-cell activation

31 March 2020

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Role of protein kinase C in T-cell antigen receptor regulation of p21ras: evidence that two p21ras regulatory pathways coexist in T cells

31 March 2020

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Integration of calcium and Ras signalling.

31 March 2020

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RasGRP, a Ras guanyl nucleotide- releasing protein with calcium- and diacylglycerol-binding motifs

31 March 2020

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Phospholipase Cgamma activates Ras on the Golgi apparatus by means of RasGRP1

31 March 2020

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RasGRP is essential for mouse thymocyte differentiation and TCR signaling

31 March 2020

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Disruption of diacylglycerol metabolism impairs the induction of T cell anergy.

31 March 2020

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T cell anergy is reversed by active Ras and is regulated by diacylglycerol kinase-alpha

31 March 2020

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Regulation of T cell receptor-induced activation of the Ras-ERK pathway by diacylglycerol kinase zeta

31 March 2020

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Enhanced T cell responses due to diacylglycerol kinase zeta deficiency

31 March 2020

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Transcriptional mechanisms underlying lymphocyte tolerance.

31 March 2020

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Constitutive active p21ras enhances primary T cell responsiveness to Ca2+ signals without interfering with the induction of clonal anergy

31 March 2020

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Regulation of life and death by the zinc finger transcription factor Egr-1.

31 March 2020

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Early growth response gene-2, a zinc-finger transcription factor, is required for full induction of clonal anergy in CD4+ T cells

31 March 2020

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Egr-2 and Egr-3 are negative regulators of T cell activation.

31 March 2020

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Examining multiprotein signaling complexes from all angles

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Impaired activation and localization of LAT in anergic T cells as a consequence of a selective palmitoylation defect.

31 March 2020

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Isolation of a polypeptide that has lymphocyte-differentiating properties and is probably represented universally in living cells

31 March 2020

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Polyubiquitin chains: polymeric protein signals

31 March 2020

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SLIM is a nuclear ubiquitin E3 ligase that negatively regulates STAT signaling

31 March 2020

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Deltex regulates T-cell activation by targeted degradation of active MEKK1.

31 March 2020

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A novel E3 ubiquitin ligase TRAC-1 positively regulates T cell activation

31 March 2020

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A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity

31 March 2020

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Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins

31 March 2020

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GRAIL: an E3 ubiquitin ligase that inhibits cytokine gene transcription is expressed in anergic CD4+ T cells

31 March 2020

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E3 ubiquitin ligases as T cell anergy factors.

31 March 2020

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Tyrosine phosphorylation and complex formation of Cbl-b upon T cell receptor stimulation

31 March 2020

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Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b

31 March 2020

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Cbl-b regulates the CD28 dependence of T-cell activation.

31 March 2020

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Cutting edge: Cbl-b: one of the key molecules tuning CD28- and CTLA-4-mediated T cell costimulation

31 March 2020

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Cutting Edge: Regulation of T Cell Activation Threshold by CD28 Costimulation Through Targeting Cbl-b for Ubiquitination

31 March 2020

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Cbl-b, a member of the Sli-1/c-Cbl protein family, inhibits Vav-mediated c-Jun N-terminal kinase activation.

31 March 2020

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Cbl-b is a negative regulator of receptor clustering and raft aggregation in T cells

31 March 2020

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T lymphocyte costimulation mediated by reorganization of membrane microdomains

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Proteolysis-independent regulation of PI3K by Cbl-b-mediated ubiquitination in T cells.

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Cbl-b, a RING-type E3 ubiquitin ligase, targets phosphatidylinositol 3-kinase for ubiquitination in T cells.

31 March 2020

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Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav

31 March 2020

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Essential role of the E3 ubiquitin ligase Cbl-b in T cell anergy induction.

31 March 2020

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Scaffolding of antigen receptors for immunogenic versus tolerogenic signaling.

31 March 2020

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Activation-induced ubiquitination of the T cell antigen receptor

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T cell antigen receptor ubiquitination is a consequence of receptor-mediated tyrosine kinase activation

31 March 2020

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Down-regulation of T cell receptors on self-reactive T cells as a novel mechanism for extrathymic tolerance induction.

31 March 2020

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Altered thymic positive selection and intracellular signals in Cbl-deficient mice

31 March 2020

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Loss of c-Cbl RING finger function results in high-intensity TCR signaling and thymic deletion.

31 March 2020

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c-Cbl and Cbl-b regulate T cell responsiveness by promoting ligand-induced TCR down-modulation

31 March 2020

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Establishment of the major compatibility complex-dependent development of CD4+ and CD8+ T cells by the Cbl family proteins

31 March 2020

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31 March 2020

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The E3 ubiquitin ligase GREUL1 anteriorizes ectoderm during Xenopus development

31 March 2020

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Two isoforms of otubain 1 regulate T cell anergy via GRAIL

31 March 2020

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A novel E3 ubiquitin ligase substrate screen identifies Rho guanine dissociation inhibitor as a substrate of gene related to anergy in lymphocytes

31 March 2020

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Rho signalling at a glance

31 March 2020

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The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice

31 March 2020

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The HECT domain ligase itch ubiquitinates endophilin and localizes to the trans-Golgi network and endosomal system

31 March 2020

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Dysregulation of T lymphocyte function in itchy mice: a role for Itch in TH2 differentiation.

31 March 2020

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Jun turnover is controlled through JNK-dependent phosphorylation of the E3 ligase Itch

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Activation of the E3 ubiquitin ligase Itch through a phosphorylation-induced conformational change

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Negative regulation of the E3 ubiquitin ligase itch via Fyn-mediated tyrosine phosphorylation.

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Ubiquitin-mediated fluorescence complementation reveals that Jun ubiquitinated by Itch/AIP4 is localized to lysosomes.

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Convergence of Itch-induced ubiquitination with MEKK1-JNK signaling in Th2 tolerance and airway inflammation

31 March 2020

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N4WBP5, a potential target for ubiquitination by the Nedd4 family of proteins, is a novel Golgi-associated protein

31 March 2020

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Ndfip1 protein promotes the function of itch ubiquitin ligase to prevent T cell activation and T helper 2 cell-mediated inflammation

31 March 2020

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Cloning and characterization of N4WBP5A, an inducible, cyclosporine-sensitive, Nedd4-binding protein in human T lymphocytes

31 March 2020

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WW domain HECT E3s target Cbl RING finger E3s for proteasomal degradation

31 March 2020

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The ubiquitin ligase itch is auto-ubiquitylated in vivo and in vitro but is protected from degradation by interacting with the deubiquitylating enzyme FAM/USP9X

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Ubiquitin-binding domains

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Regulation of ZAP-70 activation and TCR signaling by two related proteins, Sts-1 and Sts-2

31 March 2020

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Suppressors of T-cell receptor signaling Sts-1 and Sts-2 bind to Cbl and inhibit endocytosis of receptor tyrosine kinases

31 March 2020

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TULA: an SH3- and UBA-containing protein that binds to c-Cbl and ubiquitin

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Mechanisms underlying ubiquitination

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A genomic and functional inventory of deubiquitinating enzymes

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Ubiquitination on nonlysine residues by a viral E3 ubiquitin ligase

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B-cell anergy: from transgenic models to naturally occurring anergic B cells?

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRI2131

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16 August 2017

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