Loss of c-Cbl RING finger function results in high-intensity TCR signaling and thymic deletion. (Q39491192)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16211006%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

title

Loss of c-Cbl RING finger function results in high-intensity TCR signaling and thymic deletion (English)

1 reference

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7 January 2020

3

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7 January 2020

Andrew M Lew

4

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7 January 2020

Christopher E Andoniou

6

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7 January 2020

author name string

Christine B F Thien

1

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7 January 2020

Frøydis D Blystad

2

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7 January 2020

Valentina Voigt

5

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7 January 2020

Wallace Y Langdon

7

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7 January 2020

language of work or name

English

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publication date

6 October 2005

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7 January 2020

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7 January 2020

volume

24

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7 January 2020

page(s)

3807-3819

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7 January 2020

issue

21

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A novel protein kinase B (PKB)/AKT-binding protein enhances PKB kinase activity and regulates DNA synthesis

7 January 2020

cites work

1 reference

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12 September 2017

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Catalytic domains of tyrosine kinases determine the phosphorylation sites within c-Cbl

12 September 2017

1 reference

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Ubiquitin ligases and the immune response

12 September 2017

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Negative selection and autoimmunity

12 September 2017

1 reference

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Cbl signaling networks in the regulation of cell function

12 September 2017

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Negative selection--clearing out the bad apples from the T-cell repertoire

12 September 2017

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A mouse with a loss-of-function mutation in the c-Cbl TKB domain shows perturbed thymocyte signaling without enhancing the activity of the ZAP-70 tyrosine kinase

12 September 2017

1 reference

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Without peripheral interference, thymic deletion is mediated in a cohort of double-positive cells without classical activation

12 September 2017

1 reference

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c-Cbl and Cbl-b regulate T cell responsiveness by promoting ligand-induced TCR down-modulation

12 September 2017

1 reference

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Positive and negative selection of T cells

12 September 2017

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A positive regulatory role for Cbl family proteins in tumor necrosis factor-related activation-induced cytokine (trance) and CD40L-mediated Akt activation.

12 September 2017

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Cbl: many adaptations to regulate protein tyrosine kinases

12 September 2017

1 reference

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RING finger mutations that abolish c-Cbl-directed polyubiquitination and downregulation of the EGF receptor are insufficient for cell transformation

12 September 2017

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Protein kinase B regulates T lymphocyte survival, nuclear factor kappaB activation, and Bcl-X(L) levels in vivo

12 September 2017

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Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1

12 September 2017

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Constitutive Bcl-2 expression throughout the hematopoietic compartment affects multiple lineages and enhances progenitor cell survival

12 September 2017

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Cellular survival: a play in three Akts

12 September 2017

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The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB.

12 September 2017

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The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase

12 September 2017

1 reference

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Fyn associates with Cbl and phosphorylates tyrosine 731 in Cbl, a binding site for phosphatidylinositol 3-kinase

12 September 2017

1 reference

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Altered thymic positive selection and intracellular signals in Cbl-deficient mice

12 September 2017

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CD5 expression is developmentally regulated by T cell receptor (TCR) signals and TCR avidity

12 September 2017

1 reference

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The JNK pathway regulates the In vivo deletion of immature CD4(+)CD8(+) thymocytes

12 September 2017

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Tissue hyperplasia and enhanced T-cell signalling via ZAP-70 in c-Cbl-deficient mice

12 September 2017

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Coordinated regulation of the tyrosine phosphorylation of Cbl by Fyn and Syk tyrosine kinases

12 September 2017

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Fyn, Yes, and Syk phosphorylation sites in c-Cbl map to the same tyrosine residues that become phosphorylated in activated T cells

12 September 2017

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T cell receptor (TCR)-induced death of immature CD4+CD8+ thymocytes by two distinct mechanisms differing in their requirement for CD28 costimulation: implications for negative selection in the thymus

12 September 2017

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Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

12 September 2017

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Activation events during thymic selection

12 September 2017

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Calcineurin B1 is essential for positive but not negative selection during thymocyte development

12 September 2017

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Regulation of stem cell factor receptor signaling by Cbl family proteins (Cbl-b/c-Cbl).

14 September 2017

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14 September 2017

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Negative selection in the thymus includes semimature T cells

17 June 2018

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Constitutively active protein kinase B enhances Lck and Erk activities and influences thymocyte selection and activation

17 June 2018

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Thymocyte apoptosis induced by T cell activation is mediated by glucocorticoids in vivo

21 August 2018

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Differential roles of ERK and p38 MAP kinase pathways in positive and negative selection of T lymphocytes.

21 August 2018

1 reference

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CD4 help-independent induction of cytotoxic CD8 cells to allogeneic P815 tumor cells is absolutely dependent on costimulation

21 August 2018

1 reference

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The RING Finger Domain of Cbl Is Essential for Negative Regulation of the Syk Tyrosine Kinase

4 November 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FSJ.EMBOJ.7600841

Predominant transgene expression in exocrine pancreas directed by the CMV promoter

21 January 2018

1 reference

12 December 2020

Cbl and Cbl-b in T-cell regulation

1 reference

12 December 2020

CD28 costimulation mediates down-regulation of p27kip1 and cell cycle progression by activation of the PI3K/PKB signaling pathway in primary human T cells

1 reference

12 December 2020

A role for CD5 in TCR-mediated signal transduction and thymocyte selection

1 reference

12 December 2020

Antigen-specific and nonspecific deletion of immature cortical thymocytes caused by antigen injection

1 reference

12 December 2020

Perturbed regulation of ZAP-70 and sustained tyrosine phosphorylation of LAT and SLP-76 in c-Cbl-deficient thymocytes

1 reference

12 December 2020

Identifiers

DOI

10.1038/SJ.EMBOJ.7600841

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16211006%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16211006%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

1 reference