Lipodystrophy in HIV 1-infected patients: lessons for obesity research (Q36891873)

16 August 2017

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title

Lipodystrophy in HIV 1-infected patients: lessons for obesity research (English)

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16 August 2017

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Villarroya F

1

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16 August 2017

Domingo P

series ordinal

2

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16 August 2017

Giralt M

series ordinal

3

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16 August 2017

language of work or name

English

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publication date

24 July 2007

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International Journal of Obesity

16 August 2017

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16 August 2017

31

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16 August 2017

12

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16 August 2017

1763-1776

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https://scigraph.springernature.com/pub.10.1038/sj.ijo.0803698

16 August 2017

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cites work

Cardiovascular risk and body-fat abnormalities in HIV-infected adults

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

Current concepts in the diagnosis and management of metabolic complications of HIV infection and its therapy.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

Therapeutic approaches to combating lipoatrophy: do they work?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

Regulation of adiponectin in human immunodeficiency virus-infected patients: relationship to body composition and metabolic indices

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

Lipoatrophy revisited

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

The HIV-1 nucleoside reverse transcriptase inhibitors stavudine and zidovudine alter adipocyte functions in vitro

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

Microarray analysis during adipogenesis identifies new genes altered by antiretroviral drugs

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

In vitro suppression of the lipogenic pathway by the nonnucleoside reverse transcriptase inhibitor efavirenz in 3T3 and human preadipocytes or adipocytes.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

C/EBPalpha reverses the anti-adipogenic effects of the HIV protease inhibitor nelfinavir

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

Association between altered expression of adipogenic factor SREBP1 in lipoatrophic adipose tissue from HIV-1-infected patients and abnormal adipocyte differentiation and insulin resistance

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

The HIV protease inhibitor indinavir impairs sterol regulatory element-binding protein-1 intranuclear localization, inhibits preadipocyte differentiation, and induces insulin resistance

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

Synergistic antiadipogenic effects of HIV type 1 protease inhibitors with tumor necrosis factor alpha: suppression of extracellular insulin action mediated by extracellular matrix-degrading proteases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

1 reference

7 January 2021

Mitochondrial DNA depletion and morphologic changes in adipocytes associated with nucleoside reverse transcriptase inhibitor therapy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

Improvements in lipoatrophy, mitochondrial DNA levels and fat apoptosis after replacing stavudine with abacavir or zidovudine

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

Changes in body composition and mitochondrial nucleic acid content in patients switched from failed nucleoside analogue therapy to ritonavir-boosted indinavir and efavirenz.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

Mitochondrial biogenesis and remodeling during adipogenesis and in response to the insulin sensitizer rosiglitazone

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

Expression of the thermogenic nuclear hormone receptor coactivator PGC-1α is reduced in the adipose tissue of morbidly obese subjects

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

Downregulation of Electron Transport Chain Genes in Visceral Adipose Tissue in Type 2 Diabetes Independent of Obesity and Possibly Involving Tumor Necrosis Factor-

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

Adipose gene expression patterns of weight gain suggest counteracting steroid hormone synthesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

Expression of the mitochondrial uncoupling protein gene from the aP2 gene promoter prevents genetic obesity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

Inhibition of preadipocyte proliferation by mitochondrial reactive oxygen species.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

Mitochondrial reactive oxygen species control the transcription factor CHOP-10/GADD153 and adipocyte differentiation: a mechanism for hypoxia-dependent effect

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

Mitochondria are impaired in the adipocytes of type 2 diabetic mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

Role of energy charge and AMP-activated protein kinase in adipocytes in the control of body fat stores

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

Induced adiposity and adipocyte hypertrophy in mice lacking the AMP-activated protein kinase-alpha2 subunit

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

Increased oxidative stress in obesity and its impact on metabolic syndrome

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

Uncoupling protein-2 controls adiponectin gene expression in adipose tissue through the modulation of reactive oxygen species production.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

"Buffalo hump" in men with HIV-1 infection.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

"Buffalo hump" in HIV-1 infection

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

Facial lipohypertrophy in HIV-infected subjects who underwent autologous fat tissue transplantation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

Uncoupling protein 1 gene expression implicates brown adipocytes in highly active antiretroviral therapy-associated lipomatosis.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

Retinoblastoma protein functions as a molecular switch determining white versus brown adipocyte differentiation.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

Brown adipose tissue: function and physiological significance

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https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

Uncoupling protein-1 mRNA expression in lipomas from patients bearing pathogenic mitochondrial DNA mutations

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

Altered expression of master regulatory genes of adipogenesis in lipomas from patients bearing tRNALys point mutations in mitochondrial DNA

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https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

Are 'buffalo hump' syndrome, Madelung's disease and multiple symmetrical lipomatosis variants of the same dysmetabolism?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

Buffalo hump seen in HIV-associated lipodystrophy is associated with hyperinsulinemia but not dyslipidemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

The role of brown adipose tissue in human obesity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

Reduced Expression of FOXC2 and Brown Adipogenic Genes in Human Subjects with Insulin Resistance

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

Mechanisms of the depot specificity of peroxisome proliferator-activated receptor gamma action on adipose tissue metabolism

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

Thiazolidinediones and Rexinoids Induce Peroxisome Proliferator-Activated Receptor-Coactivator (PGC)-1α Gene Transcription: An Autoregulatory Loop Controls PGC-1α Expression in Adipocytes via Peroxisome Proliferator-Activated Receptor-γ Coactivati

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

Pioglitazone induces mitochondrial biogenesis in human subcutaneous adipose tissue in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

Unexpected evidence for active brown adipose tissue in adult humans

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

HIV lipodystrophy: prevalence, severity and correlates of risk in Australia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

Anthropometrics and examiner-reported body habitus abnormalities in the multicenter AIDS cohort study

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

Hypertriglyceridemia in the acquired immunodeficiency syndrome

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

The esterified plasma fatty acid profile is altered in early HIV-1 infection

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

Highly active antiretroviral therapy-induced lipodystrophy has minor effects on human immunodeficiency virus-induced changes in lipolysis, but normalizes resting energy expenditure

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

Human adipose cells express CD4, CXCR4, and CCR5 [corrected] receptors: a new target cell type for the immunodeficiency virus-1?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

HIV and antiretroviral drug distribution in plasma and fat tissue of HIV-infected patients with lipodystrophy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

In vitro infection of human primary adipose cells with HIV-1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

Tumor necrosis factor-alpha stimulates HIV-1 production in primary culture of human adipocytes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

HIV-1 infection of mononuclear phagocytic cells: the case for bacterial innate immune deficiency in AIDS.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

Human immunodeficiency virus type-1 accessory protein Vpr: a causative agent of the AIDS-related insulin resistance/lipodystrophy syndrome?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

A review of HIV-1 Tat protein biological effects

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

HIV-1 accessory protein Vpr inhibits the effect of insulin on the Foxo subfamily of forkhead transcription factors by interfering with their binding to 14-3-3 proteins: potential clinical implications regarding the insulin resistance of HIV-1-infect

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

Effects of transgenic expression of HIV-1 Vpr on lipid and energy metabolism in mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

Human immunodeficiency virus type 1 (HIV-1) Vpr-regulated cell death: insights into mechanism

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

Lipodystrophy following hepatitis infection: a causative relationship?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

Is there a relationship between hepatitis C virus infection and antiretroviral-associated lipoatrophy?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

Human adenovirus-36 is associated with increased body weight and paradoxical reduction of serum lipids

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

Virus-induced obesity

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https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

Increased adiposity in animals due to a human virus

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https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

A human adenovirus enhances preadipocyte differentiation.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

Adipose tissue expression of IL-18 and HIV-associated lipodystrophy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

Increased systemic and adipose tissue cytokines in patients with HIV-associated lipodystrophy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

Increased expression of TNF-alpha, IL-6, and IL-8 in HALS: implications for reduced adiponectin expression and plasma levels

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

Longitudinal evolution of HIV-1-associated lipodystrophy is correlated to serum cortisol:DHEA ratio and IFN-alpha

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

Subcutaneous adipocyte apoptosis in HIV-1 protease inhibitor-associated lipodystrophy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

The effects of HIV infection on endothelial function

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

Clinical aspects of endothelial dysfunction associated with human immunodeficiency virus infection and antiretroviral agents

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

HIV-1 Tat promotes monocyte chemoattractant protein-1 secretion followed by transmigration of monocytes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

Release of interleukins and other inflammatory cytokines by human adipose tissue is enhanced in obesity and primarily due to the nonfat cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

Tumour necrosis factor alpha in fat redistribution syndromes associated with combination antiretroviral therapy in HIV-1-infected patients: potential role in subcutaneous adipocyte apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

Tumor necrosis factor alpha: a key component of the obesity-diabetes link

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

Inflammation, stress, and diabetes

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https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

Obesity is associated with macrophage accumulation in adipose tissue

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https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

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https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

CCR2 modulates inflammatory and metabolic effects of high-fat feeding

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https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

Inflammation and metabolic disorders

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https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

Inflamed fat: what starts the fire?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

Increased rates of lipolysis among human immunodeficiency virus-infected men receiving highly active antiretroviral therapy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

Improved triglycerides and insulin sensitivity with 3 months of acipimox in human immunodeficiency virus-infected patients with hypertriglyceridemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

The HIV protease inhibitor saquinavir impairs lipid metabolism and glucose transport in cultured adipocytes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

Markedly diminished lipolysis and partial restoration of glucose metabolism, without changes in fat distribution after extended discontinuation of protease inhibitors in severe lipodystrophic human immunodeficient virus-1-infected patients

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

Interleukin-6 Regulates Human Adipose Tissue Lipid Metabolism and Leptin Productionin Vitro

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

Tumor necrosis factor alpha stimulates lipolysis in adipocytes by decreasing Gi protein concentrations

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

Tumor necrosis factor alpha is associated with insulin-mediated suppression of free fatty acids and net lipid oxidation in HIV-infected patients with lipodystrophy.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

A paracrine loop between adipocytes and macrophages aggravates inflammatory changes: role of free fatty acids and tumor necrosis factor alpha

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

Thematic review series: patient-oriented research. Free fatty acid metabolism in human obesity

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https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

Importance of TNFalpha and neutral lipases in human adipose tissue lipolysis

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https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

Adipose cell apoptosis: death in the energy depot

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https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

Tumor necrosis factor-alpha induces apoptosis of human adipose cells

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https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

Novel treatments for obesity and osteoporosis: targeting apoptotic pathways in adipocytes

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https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

Docosahexaenoic acid inhibits adipocyte differentiation and induces apoptosis in 3T3-L1 preadipocytes.

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https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

Inhibition of adenine nucleotide translocator pore function and protection against apoptosis in vivo by an HIV protease inhibitor

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https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

Ultrastructural features of highly active antiretroviral therapy-associated partial lipodystrophy.

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https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

Switching to nevirapine decreases insulin levels but does not improve subcutaneous adipocyte apoptosis in patients with highly active antiretroviral therapy-associated lipodystrophy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

Lipodystrophy associated with highly active anti-retroviral therapy for HIV infection: the adipocyte as a target of anti-retroviral-induced mitochondrial toxicity.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

AMPK activation regulates apoptosis, adipogenesis, and lipolysis by eIF2alpha in adipocytes

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https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

Fat apoptosis through targeted activation of caspase 8: a new mouse model of inducible and reversible lipoatrophy

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https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

IFN-alpha induces apoptosis of adipose tissue cells

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https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans

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https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

Visceral abdominal-fat accumulation associated with use of indinavir

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https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

Do regional differences in adipocyte biology provide new pathophysiological insights?

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https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

Regional differences in oxidative capacity of rat white adipose tissue are linked to the mitochondrial content of mature adipocytes

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https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

Site specific alterations of adipose tissue mitochondria in 3'-azido-3'-deoxythymidine (AZT)-treated rats: an early stage in lipodystrophy?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

Higher production of IL-8 in visceral vs. subcutaneous adipose tissue. Implication of nonadipose cells in adipose tissue

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

Comparison of the release of adipokines by adipose tissue, adipose tissue matrix, and adipocytes from visceral and subcutaneous abdominal adipose tissues of obese humans

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

Monocyte chemoattractant protein-1 release is higher in visceral than subcutaneous human adipose tissue (AT): implication of macrophages resident in the AT.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

Differences in mRNA expression of the proteins secreted by the adipocytes in human subcutaneous and visceral adipose tissues

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https://api.crossref.org/works/10.1038%2FSJ.IJO.0803698

7 January 2021

Identifiers

DOI

10.1038/SJ.IJO.0803698

1 reference

Dimensions Publication ID

16 August 2017

0 references

1 reference