Promiscuity and the single receptor: NKG2D. (Q36900826)

17 August 2017

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title

Promiscuity and the single receptor: NKG2D. (English)

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17 August 2017

Robert A Eagle

1

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PubMed ID

17673918

17 August 2017

John Trowsdale

series ordinal

2

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PubMed ID

17673918

17 August 2017

language of work or name

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3 August 2007

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Nature Reviews Immunology

17 August 2017

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17 August 2017

7

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17 August 2017

9

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17 August 2017

737-744

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In search of the 'missing self': MHC molecules and NK cell recognition

17 August 2017

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Cellular ligands of activating NK receptors.

31 March 2020

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Direct recognition of cytomegalovirus by activating and inhibitory NK cell receptors

31 March 2020

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Recognition of haemagglutinins on virus-infected cells by NKp46 activates lysis by human NK cells

31 March 2020

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31 March 2020

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Roles of the NKG2D immunoreceptor and its ligands

31 March 2020

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Identification of PVR (CD155) and Nectin-2 (CD112) as cell surface ligands for the human DNAM-1 (CD226) activating molecule

31 March 2020

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A novel dendritic cell subset involved in tumor immunosurveillance

31 March 2020

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Interferon-producing killer dendritic cells provide a link between innate and adaptive immunity

31 March 2020

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Natural killer cells as an initial defense against pathogens

31 March 2020

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The role of the NKG2D receptor for tumor immunity

31 March 2020

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The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor

31 March 2020

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Cell stress-regulated human major histocompatibility complex class I gene expressed in gastrointestinal epithelium

31 March 2020

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Promoter region architecture and transcriptional regulation of the genes for the MHC class I-related chain A and B ligands of NKG2D.

31 March 2020

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Stimulation of T cell autoreactivity by anomalous expression of NKG2D and its MIC ligands in rheumatoid arthritis

31 March 2020

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A direct role for NKG2D/MICA interaction in villous atrophy during celiac disease.

31 March 2020

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Coordinated induction by IL15 of a TCR-independent NKG2D signaling pathway converts CTL into lymphokine-activated killer cells in celiac disease.

31 March 2020

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Impairment of NK cell function by NKG2D modulation in NOD mice

31 March 2020

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A second lineage of mammalian major histocompatibility complex class I genes

31 March 2020

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Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA

31 March 2020

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ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor

31 March 2020

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ULBP4 is a novel ligand for human NKG2D

31 March 2020

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Two human ULBP/RAET1 molecules with transmembrane regions are ligands for NKG2D

31 March 2020

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Ligands for the murine NKG2D receptor: expression by tumor cells and activation of NK cells and macrophages.

31 March 2020

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Retinoic acid early inducible genes define a ligand family for the activating NKG2D receptor in mice

31 March 2020

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Cutting edge: murine UL16-binding protein-like transcript 1: a newly described transcript encoding a high-affinity ligand for murine NKG2D.

31 March 2020

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A novel ligand for the NKG2D receptor activates NK cells and macrophages and induces tumor immunity

31 March 2020

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A cluster of ten novel MHC class I related genes on human chromosome 6q24.2-q25.3

31 March 2020

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MICA and MICB genes: can the enigma of their polymorphism be resolved?

31 March 2020

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Genomic organization and evolution of the ULBP genes in cattle

31 March 2020

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ULBPs, human ligands of the NKG2D receptor, stimulate tumor immunity with enhancement by IL-15.

31 March 2020

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Porcine UL16-binding protein 1 expressed on the surface of endothelial cells triggers human NK cytotoxicity through NKG2D.

31 March 2020

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MIC-A polymorphism in Japanese and a MIC-A-MIC-B null haplotype.

31 March 2020

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Escape of mutant double-stranded DNA virus from innate immune control.

31 March 2020

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NKp46 and NKG2D recognition of infected dendritic cells is necessary for NK cell activation in the human response to influenza infection.

31 March 2020

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The switch from latent to productive infection in epstein-barr virus-infected B cells is associated with sensitization to NK cell killing.

31 March 2020

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Selective intracellular retention of virally induced NKG2D ligands by the human cytomegalovirus UL16 glycoprotein

31 March 2020

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Intracellular retention of the MHC class I-related chain B ligand of NKG2D by the human cytomegalovirus UL16 glycoprotein

31 March 2020

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Human cytomegalovirus glycoprotein UL16 causes intracellular sequestration of NKG2D ligands, protecting against natural killer cell cytotoxicity

31 March 2020

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Expression of the UL16 glycoprotein of Human Cytomegalovirus protects the virus-infected cell from attack by natural killer cells

31 March 2020

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Effects of human cytomegalovirus infection on ligands for the activating NKG2D receptor of NK cells: up-regulation of UL16-binding protein (ULBP)1 and ULBP2 is counteracted by the viral UL16 protein

31 March 2020

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Recognition of a virus-encoded ligand by a natural killer cell activation receptor

31 March 2020

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Effect of human cytomegalovirus on expression of MHC class I-related chains A.

31 March 2020

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Down-regulation of the NKG2D ligand MICA by the human cytomegalovirus glycoprotein UL142

31 March 2020

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Rae1 and H60 ligands of the NKG2D receptor stimulate tumour immunity

31 March 2020

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Ectopic expression of retinoic acid early inducible-1 gene (RAE-1) permits natural killer cell-mediated rejection of a MHC class I-bearing tumor in vivo

31 March 2020

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NKG2D function protects the host from tumor initiation

31 March 2020

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Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation

31 March 2020

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Transforming growth factor beta 1 inhibits expression of NKp30 and NKG2D receptors: consequences for the NK-mediated killing of dendritic cells

31 March 2020

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Elevated TGF-beta1 secretion and down-modulation of NKG2D underlies impaired NK cytotoxicity in cancer patients.

31 March 2020

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Loss of nonclassical MHC molecules MIC-A/B expression during progression of uveal melanoma

31 March 2020

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Functional expression and release of ligands for the activating immunoreceptor NKG2D in leukemia

31 March 2020

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Vdelta1 T lymphocytes from B-CLL patients recognize ULBP3 expressed on leukemic B cells and up-regulated by trans-retinoic acid.

31 March 2020

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TGF-beta and metalloproteinases differentially suppress NKG2D ligand surface expression on malignant glioma cells

31 March 2020

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Downregulation and/or release of NKG2D ligands as immune evasion strategy of human neuroblastoma

31 March 2020

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Regulation of NKG2D ligand gene expression.

31 March 2020

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BCR/ABL oncogene directly controls MHC class I chain-related molecule A expression in chronic myelogenous leukemia

31 March 2020

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Natural killer cell-mediated lysis of hepatoma cells via specific induction of NKG2D ligands by the histone deacetylase inhibitor sodium valproate

31 March 2020

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A scan for positively selected genes in the genomes of humans and chimpanzees

31 March 2020

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Positive selection in the evolution of cancer

31 March 2020

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IFNgamma and lymphocytes prevent primary tumour development and shape tumour immunogenicity

31 March 2020

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A role for activation-induced cytidine deaminase in the host response against a transforming retrovirus

31 March 2020

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Adenovirus serotype 5 E1A sensitizes tumor cells to NKG2D-dependent NK cell lysis and tumor rejection

31 March 2020

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Thermodynamic analysis of degenerate recognition by the NKG2D immunoreceptor: not induced fit but rigid adaptation

31 March 2020

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Molecular Competition for NKG2D

31 March 2020

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Interactions of human NKG2D with its ligands MICA, MICB, and homologs of the mouse RAE-1 protein family

31 March 2020

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What is the importance of the immunological synapse?

31 March 2020

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Cell surface organization of stress-inducible proteins ULBP and MICA that stimulate human NK cells and T cells via NKG2D

31 March 2020

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Stress management: MHC class I and class I-like molecules as reporters of cellular stress

31 March 2020

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NKG2D ligands are expressed on stressed human airway epithelial cells

31 March 2020

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A basolateral sorting motif in the MICA cytoplasmic tail.

31 March 2020

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Genomic structures and characterization of Rae1 family members encoding GPI-anchored cell surface proteins and expressed predominantly in embryonic mouse brain

31 March 2020

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Function of NKG2D in natural killer cell-mediated rejection of mouse bone marrow grafts

31 March 2020

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Interaction between human NK cells and bone marrow stromal cells induces NK cell triggering: role of NKp30 and NKG2D receptors

31 March 2020

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Placenta-derived soluble MHC class I chain-related molecules down-regulate NKG2D receptor on peripheral blood mononuclear cells during human pregnancy: a possible novel immune escape mechanism for fetal survival.

31 March 2020

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Cutting edge: Toll-like receptor signaling in macrophages induces ligands for the NKG2D receptor

31 March 2020

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Reciprocal regulation of human natural killer cells and macrophages associated with distinct immune synapses

31 March 2020

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Activated, but not resting, T cells can be recognized and killed by syngeneic NK cells

31 March 2020

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The abundant NK cells in human secondary lymphoid tissues require activation to express killer cell Ig-like receptors and become cytolytic

31 March 2020

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Binding of Escherichia coli adhesin AfaE to CD55 triggers cell-surface expression of the MHC class I-related molecule MICA

31 March 2020

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NKG2D blockade prevents autoimmune diabetes in NOD mice

31 March 2020

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Fas-ligand-mediated paracrine T cell regulation by the receptor NKG2D in tumor immunity.

31 March 2020

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Expression and function of NKG2D in CD4+ T cells specific for human cytomegalovirus.

31 March 2020

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The activating NKG2D receptor assembles in the membrane with two signaling dimers into a hexameric structure.

31 March 2020

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Human cytomegalovirus encodes an MHC class I-like molecule (UL142) that functions to inhibit NK cell lysis

31 March 2020

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TLR signaling in the gut in health and disease

31 March 2020

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A new polymorphic and multicopy MHC gene family related to nonmammalian class I

31 March 2020

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A novel secreted tumor antigen with a glycosylphosphatidylinositol-anchored structure ubiquitously expressed in human cancers

31 March 2020

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Letal, A tumor-associated NKG2D immunoreceptor ligand, induces activation and expansion of effector immune cells

31 March 2020

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MCMV glycoprotein gp40 confers virus resistance to CD8+ T cells and NK cells in vivo.

31 March 2020

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NKG2D-mediated natural killer cell protection against cytomegalovirus is impaired by viral gp40 modulation of retinoic acid early inducible 1 gene molecules

31 March 2020

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The cytomegalovirus m155 gene product subverts natural killer cell antiviral protection by disruption of H60-NKG2D interactions

31 March 2020

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Selective down-regulation of the NKG2D ligand H60 by mouse cytomegalovirus m155 glycoprotein

31 March 2020

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The herpesviral Fc receptor fcr-1 down-regulates the NKG2D ligands MULT-1 and H60.

31 March 2020

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NK cell activation through the NKG2D ligand MULT-1 is selectively prevented by the glycoprotein encoded by mouse cytomegalovirus gene m145.

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRI2144

1 reference

17 August 2017

1 reference

PubMed ID

17673918