Enzymatic transition state theory and transition state analogue design (Q36906493)

17 August 2017

1 reference

title

Enzymatic transition state theory and transition state analogue design (English)

1 reference

17 August 2017

Vern L Schramm

1

1 reference

PubMed ID

17690091

17 August 2017

language of work or name

English

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publication date

9 August 2007

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Journal of Biological Chemistry

17 August 2017

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17 August 2017

282

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17 August 2017

39

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17 August 2017

28297-28300

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Molecular Architecture and Biological Reactions

17 August 2017

1 reference

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Thermodynamic and extrathermodynamic requirements of enzyme catalysis

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Enzymatic transition states: thermodynamics, dynamics and analogue design

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Ever-fluctuating single enzyme molecules: Michaelis-Menten equation revisited

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Protein dynamics and catalysis: the problems of transition state theory and the subtlety of dynamic control

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The expression of isotope effects on enzyme-catalyzed reactions

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Purine nucleoside phosphorylase. Catalytic mechanism and transition-state analysis of the arsenolysis reaction.

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One-third-the-sites transition-state inhibitors for purine nucleoside phosphorylase

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Transition state analysis for human and Plasmodium falciparum purine nucleoside phosphorylases.

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Achieving the ultimate physiological goal in transition state analogue inhibitors for purine nucleoside phosphorylase

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1 reference

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Synthesis of second-generation transition state analogues of human purine nucleoside phosphorylase

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Addition of lithiated 9-deazapurine derivatives to a carbohydrate cyclic imine: convergent synthesis of the aza-C-nucleoside immucillins.

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Forodesine, an inhibitor of purine nucleoside phosphorylase, induces apoptosis in chronic lymphocytic leukemia cells

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Novel purine nucleoside analogues for T-cell-lineage acute lymphoblastic leukaemia and lymphoma

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A proof-of-principle pharmacokinetic, pharmacodynamic, and clinical study with purine nucleoside phosphorylase inhibitor immucillin-H (BCX-1777, forodesine)

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Transition state structure of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Escherichia coli and its similarity to transition state analogues

21 January 2018

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The methionine salvage pathway compound 4-methylthio-2-oxobutanate causes apoptosis independent of down-regulation of ornithine decarboxylase.

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Thirty Years of Polyamine-Related Approaches to Cancer Therapy. Retrospect and Prospect. Part 1. Selective Enzyme Inhibitors

21 January 2018

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Transition-state structure of human 5'-methylthioadenosine phosphorylase

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Atomic motion in enzymatic reaction coordinates

21 January 2018

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Transition state structure of purine nucleoside phosphorylase and principles of atomic motion in enzymatic catalysis

21 January 2018

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A transition state analogue of 5'-methylthioadenosine phosphorylase induces apoptosis in head and neck cancers

21 January 2018

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Cross-species induction of luminescence in the quorum-sensing bacterium Vibrio harveyi

21 January 2018

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Quorum-sensing blockade as a strategy for enhancing host defences against bacterial pathogens.

21 January 2018

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Quorum-sensing systems in staphylococci as therapeutic targets

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Synthesis of a Transition State Analogue Inhibitor of Purine Nucleoside Phosphorylase via the Mannich Reaction

21 January 2018

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Transition State Analogues for Enzyme Catalysis

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.R700018200

1 reference

release_xa2c3vlymvcbze23pp4cvafbvq

17 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/xa2c3vlymvcbze23pp4cvafbvq

mapped directly with Wikidata item

24 November 2022

based on heuristic

PubMed ID

17690091

1 reference

PubMed ID

17690091