Predictive models for oral drug absorption: from in silico methods to integrated dynamical models (Q36909311)

17 August 2017

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title

Predictive models for oral drug absorption: from in silico methods to integrated dynamical models (English)

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17 August 2017

Aristides Dokoumetzidis

series ordinal

1

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17 August 2017

Lida Kalantzi

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2

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17 August 2017

Nikoletta Fotaki

series ordinal

3

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17 August 2017

language of work or name

English

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publication date

1 August 2007

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Expert Opinion on Drug Metabolism & Toxicology

17 August 2017

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17 August 2017

3

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17 August 2017

4

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17 August 2017

491-505

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Computational models to predict aqueous drug solubility, permeability and intestinal absorption

17 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.491

From physicochemistry to absorption and distribution: predictive mechanistic modelling and computational tools

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.491

Setting bioequivalence requirements for drug development based on preclinical data: optimizing oral drug delivery systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.491

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.491

A 'rule of unity' for human intestinal absorption

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.491

A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.491

The use of biopharmaceutic classification of drugs in drug discovery and development: current status and future extension

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.491

Estimating the fraction dose absorbed from suspensions of poorly soluble compounds in humans: a mathematical model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.491

Modern bioavailability, bioequivalence and biopharmaceutics classification system. New scientific approaches to international regulatory standards

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.491

Predicting drug disposition via application of BCS: transport/absorption/ elimination interplay and development of a biopharmaceutics drug disposition classification system

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.491

Quantitative biopharmaceutics classification system: the central role of dose/solubility ratio.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.491

Simulation of fasting gastric conditions and its importance for the in vivo dissolution of lipophilic compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.491

Canine intestinal contents vs. simulated media for the assessment of solubility of two weak bases in the human small intestinal contents.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.491

Solubility and partitioning I: Solubility of nonelectrolytes in water.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.491

Solubility of organic solutes in ethanol/water mixtures.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.491

Prediction of drug solubility by the general solubility equation (GSE).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.491

Estimation of the aqueous solubility I: application to organic nonelectrolytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.491

ADME evaluation in drug discovery. 4. Prediction of aqueous solubility based on atom contribution approach.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.491

Human intestinal permeability

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.491

Assessing the absorption of new pharmaceuticals

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.491

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.491

Linear correlation of the fraction of oral dose absorbed of 64 drugs between humans and rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.491

Recent advances in computational prediction of drug absorption and permeability in drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.491

QSAR analysis of membrane permeability to organic compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.491

Evaluation of physicochemical parameters important to the oral bioavailability of peptide-like compounds: implications for the synthesis of renin inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.491

Relationship between tissue selectivity and lipophilicity for inhibitors of HMG-CoA reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.491

Correlation of human jejunal permeability (in vivo) of drugs with experimentally and theoretically derived parameters. A multivariate data analysis approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.491

In silico prediction models for blood-brain barrier permeation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.491

ADMET in silico modelling: towards prediction paradise?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.491

Classification analysis of P-glycoprotein substrate specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.491

Enhancement of drug absorption by noncharged detergents through membrane and P-glycoprotein binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.491

A general pattern for substrate recognition by P-glycoprotein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.491

Structure-activity relationship of P-glycoprotein substrates and modifiers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.491

Progress in understanding the structure-activity relationships of P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.491

Progress in predicting human ADME parameters in silico

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.491

Modeling of active transport systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.491

Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.491

Predicting P-glycoprotein substrates by a quantitative structure-activity relationship model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.491

Kinetic considerations for the quantitative assessment of efflux activity and inhibition: implications for understanding and predicting the effects of efflux inhibition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.491

Saturable small intestinal drug absorption in humans: modeling and interpretation of cefatrizine data

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.491

General solution for diffusion-controlled dissolution of spherical particles. 1. Theory.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.491

Linearization of dissolution rate curves by the Weibull distribution.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.491

On the heterogeneity of drug dissolution and release

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.491

Use of fractal geometry to determine effects of surface morphology on drug dissolution.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.491

A population growth model of dissolution.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.491

A stochastic differential equation model for drug dissolution and its parameters.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.491

Forecasting the in vivo performance of four low solubility drugs from their in vitro dissolution data

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.491

In vitro-in vivo correlations for lipophilic, poorly water-soluble drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.491

Biorelevant dissolution testing to predict the plasma profile of lipophilic drugs after oral administration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.491

Forecasting the oral absorption behavior of poorly soluble weak bases using solubility and dissolution studies in biorelevant media

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.491

In vivo in vitro correlations for a poorly soluble drug, danazol, using the flow-through dissolution method with biorelevant dissolution media

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.491

Canine versus in vitro data for predicting input profiles of L-sulpiride after oral administration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.491

Biorelevant dissolution media as a predictive tool for glyburide a class II drug.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.491

In vitro assessment of oral lipid based formulations

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.491

Use of in vitro lipid digestion data to explain the in vivo performance of triglyceride-based oral lipid formulations of poorly water-soluble drugs: studies with halofantrine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.491

Lipids and lipid-based formulations: optimizing the oral delivery of lipophilic drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.491

Solubilisation of poorly water-soluble drugs during in vitro lipolysis of medium- and long-chain triacylglycerols

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.491

Use of a dynamic in vitro lipolysis model to rationalize oral formulation development for poor water soluble drugs: correlation with in vivo data and the relationship to intra-enterocyte processes in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.491

Modeling of drug release from delivery systems based on hydroxypropyl methylcellulose (HPMC).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.491

Gastrointestinal behavior of orally administered radiolabeled erythromycin pellets in man as determined by gamma scintigraphy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.491

Comparison of the rates of disintegration, gastric emptying, and drug absorption following administration of a new and a conventional paracetamol formulation, using gamma scintigraphy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.491

Magnetic markers as a noninvasive tool to monitor gastrointestinal transit.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.491

A compartmental absorption and transit model for estimating oral drug absorption.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.491

Predicting the impact of physiological and biochemical processes on oral drug bioavailability

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.491

Gastrointestinal transit and drug absorption

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.491

A physiologic model for simulating gastrointestinal flow and drug absorption in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.491

A physiological model for the estimation of the fraction dose absorbed in humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.491

Heterogeneous tube model for the study of small intestinal transit flow

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.491

Prediction of intestinal absorption: comparative assessment of GASTROPLUS and IDEA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.491

An evaluation of the utility of physiologically based models of pharmacokinetics in early drug discovery.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.491

A strategy for preclinical formulation development using GastroPlus as pharmacokinetic simulation tool and a statistical screening design applied to a dog study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.491

Predicting pharmacokinetic food effects using biorelevant solubility media and physiologically based modelling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.491

The prediction of drug metabolism, tissue distribution, and bioavailability of 50 structurally diverse compounds in rat using mechanism-based absorption, distribution, and metabolism prediction tools.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.491

Dispersion of Soluble Matter in Solvent Flowing Slowly through a Tube

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.491

Model Selection Based on Structural Similarity−Method Description and Application to Water Solubility Prediction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.491

21 January 2018

Identifiers

DOI

10.1517/17425255.3.4.491

1 reference

17 August 2017

1 reference