FcRn: the neonatal Fc receptor comes of age. (Q36912134)

17 August 2017

1 reference

title

FcRn: the neonatal Fc receptor comes of age. (English)

1 reference

17 August 2017

Shreeram Akilesh

2

0 references

author name string

Derry C Roopenian

series ordinal

1

1 reference

17 August 2017

17 August 2007

1 reference

Nature Reviews Immunology

17 August 2017

1 reference

17 August 2017

7

1 reference

17 August 2017

715-725

1 reference

17 August 2017

9

1 reference

Maturation of the maternofoetal transport system for human gamma-globulin in the mouse

17 August 2017

1 reference

The transmission of immunity from mother to young and the catabolism of immunoglobulins

31 March 2020

1 reference

Isolation and characterization of an Fc receptor from neonatal rat small intestine

31 March 2020

1 reference

An Fc receptor structurally related to MHC class I antigens

31 March 2020

1 reference

The mechanism of intestinal uptake and transcellular transport of IgG in the neonatal rat

31 March 2020

1 reference

An IgG-transporting Fc receptor expressed in the syncytiotrophoblast of human placenta

31 March 2020

1 reference

pH-dependent binding of immunoglobulins to intestinal cells of the neonatal rat

31 March 2020

1 reference

Crystal structure of the complex of rat neonatal Fc receptor with Fc

31 March 2020

1 reference

Analysis of the pH dependence of the neonatal Fc receptor/immunoglobulin G interaction using antibody and receptor variants.

31 March 2020

1 reference

Localization of the site of the murine IgG1 molecule that is involved in binding to the murine intestinal Fc receptor

31 March 2020

1 reference

Visualizing the site and dynamics of IgG salvage by the MHC class I-related receptor, FcRn.

31 March 2020

1 reference

Exocytosis of IgG as mediated by the receptor, FcRn: an analysis at the single-molecule level

31 March 2020

1 reference

Crystal structure at 2.2 A resolution of the MHC-related neonatal Fc receptor.

31 March 2020

1 reference

The chicken yolk sac IgY receptor, a functional equivalent of the mammalian MHC-related Fc receptor, is a phospholipase A2 receptor homolog.

31 March 2020

1 reference

The MHC class I-like IgG receptor controls perinatal IgG transport, IgG homeostasis, and fate of IgG-Fc-coupled drugs

31 March 2020

1 reference

The protection receptor for IgG catabolism is the beta2-microglobulin-containing neonatal intestinal transport receptor

31 March 2020

1 reference

Abnormally short serum half-lives of IgG in beta 2-microglobulin-deficient mice

31 March 2020

1 reference

Beta 2-microglobulin-, CD8+ T-cell-deficient mice survive inoculation with high doses of vaccinia virus and exhibit altered IgG responses

31 March 2020

1 reference

The major histocompatibility complex-related Fc receptor for IgG (FcRn) binds albumin and prolongs its lifespan

31 March 2020

1 reference

Perspective-- FcRn transports albumin: relevance to immunology and medicine

31 March 2020

1 reference

Evidence to support the cellular mechanism involved in serum IgG homeostasis in humans

31 March 2020

1 reference

Functional expression of the MHC class I-related receptor, FcRn, in endothelial cells of mice.

31 March 2020

1 reference

Expression of functionally active FcRn and the differentiated bidirectional transport of IgG in human placental endothelial cells

31 March 2020

1 reference

31 March 2020

1 reference

Cell surface recycling of internalized antigen permits dendritic cell priming of B cells

31 March 2020

1 reference

Distribution of the IgG Fc receptor, FcRn, in the human fetal intestine

31 March 2020

1 reference

Expression of the neonatal Fc receptor, FcRn, on human intestinal epithelial cells

31 March 2020

1 reference

Bidirectional FcRn-dependent IgG transport in a polarized human intestinal epithelial cell line

31 March 2020

1 reference

IgG transport across mucosal barriers by neonatal Fc receptor for IgG and mucosal immunity

31 March 2020

1 reference

Functional analysis of the mouse Fcgrt 5' proximal promoter.

31 March 2020

1 reference

Analysis of the promoter region of the human FcRn gene.

31 March 2020

1 reference

Human neonatal Fc receptor mediates transport of IgG into luminal secretions for delivery of antigens to mucosal dendritic cells.

31 March 2020

1 reference

Neonatal Fc receptor for IgG regulates mucosal immune responses to luminal bacteria

31 March 2020

1 reference

Expression of the neonatal Fc receptor (FcRn) at the blood-brain barrier

31 March 2020

1 reference

The blood-brain barrier: an overview: structure, regulation, and clinical implications

31 March 2020

1 reference

Mediated efflux of IgG molecules from brain to blood across the blood-brain barrier.

31 March 2020

1 reference

IgG-assisted age-dependent clearance of Alzheimer's amyloid beta peptide by the blood-brain barrier neonatal Fc receptor.

31 March 2020

1 reference

FcRn mediates elongated serum half-life of human IgG in cattle

31 March 2020

1 reference

FcRn-mediated transcytosis of immunoglobulin G in human renal proximal tubular epithelial cells

31 March 2020

1 reference

The neonatal Fc receptor (FcRn) is expressed in the bovine lung.

31 March 2020

1 reference

Receptor-mediated immunoglobulin G transport across mucosal barriers in adult life: functional expression of FcRn in the mammalian lung

31 March 2020

1 reference

Expression and transport functionality of FcRn within rat alveolar epithelium: a study in primary cell culture and in the isolated perfused lung

31 March 2020

1 reference

Net absorption of IgG via FcRn-mediated transcytosis across rat alveolar epithelial cell monolayers.

31 March 2020

1 reference

Pulmonary delivery of an erythropoietin Fc fusion protein in non-human primates through an immunoglobulin transport pathway

31 March 2020

1 reference

Delivery of an erythropoietin-Fc fusion protein by inhalation in humans through an immunoglobulin transport pathway.

31 March 2020

1 reference

Oral and pulmonary delivery of FSH-Fc fusion proteins via neonatal Fc receptor-mediated transcytosis.

31 March 2020

1 reference

Pulmonary administration of therapeutic proteins using an immunoglobulin transport pathway

31 March 2020

1 reference

Monomeric Fc fusions: impact on pharmacokinetic and biological activity of protein therapeutics

31 March 2020

1 reference

Mapping of the C1q binding site on rituxan, a chimeric antibody with a human IgG1 Fc

31 March 2020

1 reference

Crystal structure at 2.8 A of an FcRn/heterodimeric Fc complex: mechanism of pH-dependent binding

31 March 2020

1 reference

Crystal structure of a streptococcal protein G domain bound to an Fab fragment

31 March 2020

1 reference

Structure of human IgM rheumatoid factor Fab bound to its autoantigen IgG Fc reveals a novel topology of antibody-antigen interaction

31 March 2020

1 reference

Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9- and 2.8-A resolution

31 March 2020

1 reference

Structural basis of pH-dependent antibody binding by the neonatal Fc receptor

31 March 2020

1 reference

Mapping the site on human IgG for binding of the MHC class I-related receptor, FcRn

31 March 2020

1 reference

The MHC class I-related receptor, FcRn, plays an essential role in the maternofetal transfer of gamma-globulin in humans

31 March 2020

1 reference

High resolution mapping of the binding site on human IgG1 for Fc gamma RI, Fc gamma RII, Fc gamma RIII, and FcRn and design of IgG1 variants with improved binding to the Fc gamma R.

31 March 2020

1 reference

Enhanced half-life of genetically engineered human IgG1 antibodies in a humanized FcRn mouse model: potential application in humorally mediated autoimmune disease.

31 March 2020

1 reference

Identification of critical IgG binding epitopes on the neonatal Fc receptor

31 March 2020

1 reference

Multiple roles for the major histocompatibility complex class I- related receptor FcRn

31 March 2020

1 reference

Characterization of the 2:1 complex between the class I MHC-related Fc receptor and its Fc ligand in solution

31 March 2020

1 reference

Crystallization and stoichiometry of binding of a complex between a rat intestinal Fc receptor and Fc

31 March 2020

1 reference

The stoichiometry and affinity of the interaction of murine Fc fragments with the MHC class I-related receptor, FcRn

31 March 2020

1 reference

Stoichiometry of the interaction between the major histocompatibility complex-related Fc receptor and its Fc ligand

31 March 2020

1 reference

Crystal structure and immunoglobulin G binding properties of the human major histocompatibility complex-related Fc receptor(,)

31 March 2020

1 reference

Ligand valency affects transcytosis, recycling and intracellular trafficking mediated by the neonatal Fc receptor

31 March 2020

1 reference

Catabolism of the murine IgG1 molecule: evidence that both CH2-CH3 domain interfaces are required for persistence of IgG1 in the circulation of mice

31 March 2020

1 reference

Membrane-anchored human FcRn can oligomerize in the absence of IgG.

31 March 2020

1 reference

Engineered human IgG antibodies with longer serum half-lives in primates

31 March 2020

1 reference

Quantitative methods for developing Fc mutants with extended half-lives.

31 March 2020

1 reference

Engineering the Fc region of immunoglobulin G to modulate in vivo antibody levels.

31 March 2020

1 reference

Properties of human IgG1s engineered for enhanced binding to the neonatal Fc receptor (FcRn).

31 March 2020

1 reference

An engineered human IgG1 antibody with longer serum half-life.

31 March 2020

1 reference

Overview of monoclonal antibodies in cancer therapy: present and promise

31 March 2020

1 reference

Increasing the affinity of a human IgG1 for the neonatal Fc receptor: biological consequences.

31 March 2020

1 reference

Divergent activities of an engineered antibody in murine and human systems have implications for therapeutic antibodies

31 March 2020

1 reference

A Theoretical Model of γ-Globulin Catabolism

31 March 2020

1 reference

THE METABOLISM OF NORMAL PLASMA PROTEINS AND GAMMA-MYELOMA PROTEIN IN MICE BEARING PLASMA-CELL TUMORS

31 March 2020

1 reference

Mechanism of intravenous immune globulin therapy in antibody-mediated autoimmune diseases

31 March 2020

1 reference

Anti-inflammatory activity of IVIG mediated through the inhibitory Fc receptor

31 March 2020

1 reference

Complete FcRn dependence for intravenous Ig therapy in autoimmune skin blistering diseases

31 March 2020

1 reference

Investigation of the interaction between the class I MHC-related Fc receptor and its immunoglobulin G ligand.

31 March 2020

1 reference

Pharmacokinetic effects of 4C9, an anti-FcRn antibody, in rats: implications for the use of FcRn inhibitors for the treatment of humoral autoimmune and alloimmune conditions

31 March 2020

1 reference

Amelioration of experimental autoimmune myasthenia gravis in rats by neonatal FcR blockade

31 March 2020

1 reference

Convergent solutions to binding at a protein-protein interface

31 March 2020

1 reference

Prevention of systemic lupus erythematosus in MRL/lpr mice by administration of an immunoglobulin-binding peptide.

31 March 2020

1 reference

Differences in promiscuity for antibody-FcRn interactions across species: implications for therapeutic antibodies

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRI2155

1 reference

17 August 2017

1 reference

PubMed ID

17703228