Genome-wide association studies provide new insights into type 2 diabetes aetiology (Q36912145)

17 August 2017

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title

Genome-wide association studies provide new insights into type 2 diabetes aetiology (English)

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genome-wide association study

17 August 2017

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Timothy M Frayling

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publication date

1 September 2007

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17 August 2017

Nature Reviews Genetics

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17 August 2017

8

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17 August 2017

9

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17 August 2017

657-662

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https://scigraph.springernature.com/pub.10.1038/nrg2178

17 August 2017

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cites work

Type 2 (non-insulin-dependent) diabetes mellitus. New genetics for old nightmares

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Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus

31 March 2020

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Haplotype structure and genotype-phenotype correlations of the sulfonylurea receptor and the islet ATP-sensitive potassium channel gene region

31 March 2020

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Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes

31 March 2020

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The E23K variant of Kir6.2 associates with impaired post-OGTT serum insulin response and increased risk of type 2 diabetes

31 March 2020

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The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes

31 March 2020

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Two variants on chromosome 17 confer prostate cancer risk and the one in TCF2 protects against type 2 diabetes

31 March 2020

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Evaluation of Common Variants in the Six Known Maturity-Onset Diabetes of the Young (MODY) Genes for Association With Type 2 Diabetes

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Common variants in WFS1 confer risk of type 2 diabetes

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Dominant negative mutations in human PPARgamma associated with severe insulin resistance, diabetes mellitus and hypertension

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Activating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6.2 and permanent neonatal diabetes

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A gene encoding a transmembrane protein is mutated in patients with diabetes mellitus and optic atrophy (Wolfram syndrome)

31 March 2020

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Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels

31 March 2020

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A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants

31 March 2020

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A genome-wide association study identifies novel risk loci for type 2 diabetes

31 March 2020

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A variant in CDKAL1 influences insulin response and risk of type 2 diabetes

31 March 2020

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Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes

31 March 2020

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A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity

31 March 2020

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Replicating genotype-phenotype associations

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Hex homeobox gene-dependent tissue positioning is required for organogenesis of the ventral pancreas

31 March 2020

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A common variant on chromosome 9p21 affects the risk of myocardial infarction

31 March 2020

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A common allele on chromosome 9 associated with coronary heart disease

31 March 2020

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p16INK4a induces an age-dependent decline in islet regenerative potential

31 March 2020

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Inhibition of cyclin-dependent kinase 5 activity protects pancreatic beta cells from glucotoxicity

31 March 2020

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Cdk5-dependent regulation of glucose-stimulated insulin secretion.

31 March 2020

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Variation in TCF7L2 influences therapeutic response to sulfonylureas: a GoDARTs study

31 March 2020

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Genome-wide association study identifies novel breast cancer susceptibility loci

31 March 2020

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Variation in FTO contributes to childhood obesity and severe adult obesity

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31 March 2020

Identifiers

DOI

10.1038/NRG2178

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17 August 2017

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PubMed ID

17703236