A phosphatidylserine binding site in factor Va C1 domain regulates both assembly and activity of the prothrombinase complex. (Q36915890)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18587009%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

title

A phosphatidylserine binding site in factor Va C1 domain regulates both assembly and activity of the prothrombinase complex (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18587009%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

1

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9 January 2020

author name string

Mary Ann Quinn-Allen

series ordinal

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18587009%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

William H Kane

series ordinal

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18587009%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

Barry R Lentz

series ordinal

4

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9 January 2020

language of work or name

English

0 references

publication date

27 June 2008

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9 January 2020

number of pages

8

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inferred from page(s)

published in

Blood

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9 January 2020

volume

112

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9 January 2020

issue

7

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9 January 2020

page(s)

2795-2802

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18587009%20AND%20SRC:MED&resulttype=core&format=json

The phosphatidylserine binding site of the factor Va C2 domain accounts for membrane binding but does not contribute to the assembly or activity of a human factor Xa-factor Va complex

9 January 2020

cites work

1 reference

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The crystal structure of activated protein C-inactivated bovine factor Va: Implications for cofactor function

29 September 2017

1 reference

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Trp2063 and Trp2064 in the factor Va C2 domain are required for high-affinity binding to phospholipid membranes but not for assembly of the prothrombinase complex

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2556615

Effects of water soluble phosphotidylserine on bovine factor Xa: functional and structural changes plus dimerization.

29 September 2017

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Factor V: a combination of Dr Jekyll and Mr Hyde

29 September 2017

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29 September 2017

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Crystal structures of the membrane-binding C2 domain of human coagulation factor V

29 September 2017

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Partial glycosylation at asparagine-2181 of the second C-type domain of human factor V modulates assembly of the prothrombinase complex.

29 September 2017

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Roles of factor Va heavy and light chains in protein and lipid rearrangements associated with the formation of a bovine factor Va-membrane complex

29 September 2017

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Insights into the complex association of bovine factor Va with acidic-lipid-containing synthetic membranes

29 September 2017

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Localization of functionally important epitopes within the second C-type domain of coagulation factor V using recombinant chimeras

29 September 2017

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Human coagluation factor V purification and thrombin-catalyzed activation

29 September 2017

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Activation of human prothrombin by human prothrombinase. Influence of factor Va on the reaction mechanism

29 September 2017

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Blood coagulation factors V and VIII: structural and functional similarities and their relationship to hemorrhagic and thrombotic disorders

29 September 2017

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Complete cDNA and derived amino acid sequence of human factor V

29 September 2017

1 reference

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Cloning of a cDNA coding for human factor V, a blood coagulation factor homologous to factor VIII and ceruloplasmin

29 September 2017

1 reference

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The contribution of bovine Factor V and Factor Va to the activity of prothrombinase

29 September 2017

1 reference

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Efficient thrombin generation requires molecular phosphatidylserine, not a membrane surface.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2556615

Soluble phosphatidylserine binds to a single identified site in the C2 domain of human factor Va.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2556615

Studies of the role of factor Va in the factor Xa-catalyzed activation of prothrombin, fragment 1.2-prethrombin-2, and dansyl-L-glutamyl-glycyl-L-arginine-meizothrombin in the absence of phospholipid.

27 June 2018

1 reference

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Complement proteins C5b-9 induce vesiculation of the endothelial plasma membrane and expose catalytic surface for assembly of the prothrombinase enzyme complex

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2556615

Characterization of a factor Xa binding site on factor Va near the Arg-506 activated protein C cleavage site.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2556615

Mutation of hydrophobic residues in the factor Va C1 and C2 domains blocks membrane-dependent prothrombin activation

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2556615

The factor V C1 domain is involved in membrane binding: identification of functionally important amino acid residues within the C1 domain of factor V using alanine scanning mutagenesis.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2556615

Defining the factor Xa-binding site on factor Va by site-directed glycosylation

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2556615

Specificity of soluble phospholipid binding sites on human factor Xa.

4 September 2018

1 reference

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Soluble phosphatidylserine triggers assembly in solution of a prothrombin-activating complex in the absence of a membrane surface.

4 September 2018

1 reference

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Phosphatidylserine binding alters the conformation and specifically enhances the cofactor activity of bovine factor Va.

4 September 2018

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Role of procoagulant lipids in human prothrombin activation. 1. Prothrombin activation by factor X(a) in the absence of factor V(a) and in the absence and presence of membranes.

4 September 2018

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Identification of functionally important amino acid residues within the C2-domain of human factor V using alanine-scanning mutagenesis

4 September 2018

1 reference

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Binding site for blood coagulation factor Xa involving residues 311-325 in factor Va.

4 September 2018

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Soluble Phospholipids Enhance Factor Xa-Catalyzed Prothrombin Activation in Solution†

4 September 2018

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Purification and characterization of human coagulation factor V

4 December 2018

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12 December 2020

Mutations in a potential phospholipid binding loop in the C2 domain of factor V affecting the assembly of the prothrombinase complex

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12 December 2020

The active site of blood coagulation factor Xa. Its distance from the phospholipid surface and its conformational sensitivity to components of the prothrombinase complex

1 reference

12 December 2020

Role of Procoagulant Lipids in Human Prothrombin Activation. 2. Soluble Phosphatidylserine Upregulates and Directs Factor Xato Appropriate Peptide Bonds in Prothrombin†

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12 December 2020

The enzymatic synthesis of phosphatidylserine and purification by CM-cellulose column chromatography

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12 December 2020

Blood clotting in minimally altered whole blood

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12 December 2020

The subunit structure of thrombin-activated factor V. Isolation of activated factor V, separation of subunits, and reconstitution of biological activity

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12 December 2020

Proposed structural models of human factor Va and prothrombinase

1 reference

12 December 2020

A new model to describe extrinsic protein binding to phospholipid membranes of varying composition: application to human coagulation proteins

1 reference

12 December 2020

Identification of a binding site for blood coagulation factor Xa on the heavy chain of factor Va. Amino acid residues 323-331 of factor V represent an interactive site for activated factor X

1 reference

12 December 2020

Partial glycosylation of Asn2181 in human factor V as a cause of molecular and functional heterogeneity. Modulation of glycosylation efficiency by mutagenesis of the consensus sequence for N-linked glycosylation

1 reference

12 December 2020

Cooperative roles of factor V(a) and phosphatidylserine-containing membranes as cofactors in prothrombin activation

1 reference

12 December 2020

Activation of human factor V by factor Xa and thrombin

1 reference

12 December 2020

Expression of coagulant activity in human platelets: Release of membranous vesicles providing platelet factor 1 and platelet factor 3

1 reference

12 December 2020

Functional properties of human factor Va lacking the Asp683-Arg709 domain of the heavy chain

1 reference

12 December 2020

Mixed Micelles of Sodium Deoxycholate and Polyoxyethylene Sorbitan Monooleate (Tween 80)

1 reference

12 December 2020

Characterization of two forms of human factor Va with different cofactor activities

1 reference

12 December 2020

10.1182/BLOOD-2008-02-138941

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18587009%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18587009%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

PubMed publication ID

18587009

1 reference