Apolipoprotein E and neurological disease: therapeutic potential and pharmacogenomic interactions (Q36918114)

17 August 2017

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title

Apolipoprotein E and neurological disease: therapeutic potential and pharmacogenomic interactions (English)

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17 August 2017

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Daniel T Laskowitz

1

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PubMed ID

17716229

17 August 2017

Michael P Vitek

series ordinal

2

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17 August 2017

1 August 2007

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17 August 2017

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17 August 2017

8

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17 August 2017

8

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17 August 2017

959-969

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Apolipoprotein E: diversity of cellular origins, structural and biophysical properties, and effects in Alzheimer's disease

17 August 2017

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.8.959

Profile and regulation of apolipoprotein E (ApoE) expression in the CNS in mice with targeting of green fluorescent protein gene to the ApoE locus.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.8.959

Phenotypes of apolipoprotein B and apolipoprotein E after liver transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.8.959

Apolipoprotein E and the CNS response to injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.8.959

Human apolipoprotein E4 domain interaction. Arginine 61 and glutamic acid 255 interact to direct the preference for very low density lipoproteins

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.8.959

Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.8.959

Apolipoprotein E, survival in Alzheimer's disease patients, and the competing risks of death and Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.8.959

Apolipoprotein E, amyloid, and Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.8.959

Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.8.959

Differential binding of apolipoprotein E isoforms to tau and other cytoskeletal proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.8.959

Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.8.959

Apolipoprotein E epsilon 4 allele is associated with deposition of amyloid beta-protein following head injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.8.959

Association of apolipoprotein E polymorphism with outcome after head injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.8.959

Apolipoprotein E-epsilon4 genotype predicts a poor outcome in survivors of traumatic brain injury

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.8.959

APOE influences vasospasm and cognition of noncomatose patients with subarachnoid hemorrhage.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.8.959

Apolipoprotein E epsilon4 and the risk of unfavorable outcome after aneurysmal subarachnoid hemorrhage

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.8.959

Effects of apolipoprotein E genotype on outcome after ischaemic stroke, intracerebral haemorrhage and subarachnoid haemorrhage.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.8.959

Apolipoprotein E polymorphism: survival and neurological outcome after cardiopulmonary resuscitation

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.8.959

Preliminary report of a genetic basis for cognitive decline after cardiac operations. The Neurologic Outcome Research Group of the Duke Heart Center.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.8.959

APOE genotype is a major predictor of long-term progression of disability in MS

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.8.959

Apolipoprotein E epsilon 4 is associated with rapid progression of multiple sclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.8.959

Apolipoprotein E and dementia in Parkinson disease: a meta-analysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.8.959

APOE epsilon variation in multiple sclerosis susceptibility and disease severity: some answers

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.8.959

Association of APOE polymorphisms with disease severity in MS is limited to women.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.8.959

Microglial activation by Alzheimer amyloid precursor protein and modulation by apolipoprotein E.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.8.959

Apolipoprotein E isoform mediated regulation of nitric oxide release

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.8.959

Modulation of nitric oxide production in human macrophages by apolipoprotein-E and amyloid-beta peptide.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.8.959

APOE Genotype and an ApoE-mimetic Peptide Modify the Systemic and Central Nervous System Inflammatory Response

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.8.959

Apolipoprotein E protects against bacterial lipopolysaccharide-induced lethality. A new therapeutic approach to treat gram-negative sepsis.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.8.959

Apolipoprotein-E allele-specific regulation of nitric oxide production.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.8.959

APOE polymorphism is associated with risk of severe sepsis in surgical patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.8.959

Apolipoprotein E genotype differentially influences the proinflammatory and anti-inflammatory response to cardiopulmonary bypass.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.8.959

APOE genotype-specific differences in human and mouse macrophage nitric oxide production.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.8.959

Endogenous apolipoprotein E suppresses LPS-stimulated microglial nitric oxide production.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.8.959

Downregulation of microglial activation by apolipoprotein E and apoE-mimetic peptides.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.8.959

Apolipoprotein E4 polymorphism as a genetic predisposition to delirium in critically ill patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.8.959

Reactive microglia in aging and dementia: an immunohistochemical study of postmortem human brain tissue.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.8.959

Evolution of apolipoprotein E: mouse sequence and evidence for an 11-nucleotide ancestral unit

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.8.959

Introduction of human apolipoprotein E4 "domain interaction" into mouse apolipoprotein E

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.8.959

Generation of mice carrying a mutant apolipoprotein E gene inactivated by gene targeting in embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.8.959

Apolipoprotein E-deficient mice have increased susceptibility to focal cerebral ischemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.8.959

Increased neuronal damage in apolipoprotein E-deficient mice following global ischaemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.8.959

Apolipoprotein E deficiency worsens outcome from global cerebral ischemia in the mouse.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.8.959

Regional CBF in apolipoprotein E-deficient and wild type mice during focal cerebral ischemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.8.959

Motor and cognitive deficits in apolipoprotein E-deficient mice after closed head injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.8.959

Antioxidant mechanisms in apolipoprotein E deficient mice prior to and following closed head injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.8.959

Susceptibility of transgenic mice expressing human apolipoprotein E to closed head injury: the allele E3 is neuroprotective whereas E4 increases fatalities.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.8.959

Apolipoprotein E isoform-specific differences in outcome from focal ischemia in transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.8.959

Augmented delayed infarct expansion and reactive astrocytosis after permanent focal ischemia in apolipoprotein E4 knock-in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.8.959

Apolipoprotein E protects against NMDA excitotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.8.959

Apolipoprotein E receptor 2 interactions with the N-methyl-D-aspartate receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.8.959

Apolipoprotein E allele-specific antioxidant activity and effects on cytotoxicity by oxidative insults and beta-amyloid peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.8.959

Stable expression and secretion of apolipoproteins E3 and E4 in mouse neuroblastoma cells produces differential effects on neurite outgrowth

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.8.959

Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.8.959

Functions of lipoprotein receptors in neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.8.959

Apolipoprotein E receptors: linking brain development and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.8.959

Multiple pathways of apolipoprotein E signaling in primary neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.8.959

LRP and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.8.959

Apolipoprotein E isoform-dependent dendritic recovery of hippocampal neurons following activation of innate immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.8.959

Apolipoprotein E4 enhances brain inflammation by modulation of the NF-kappaB signaling cascade.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.8.959

Protective effect of apolipoprotein E-mimetic peptides on N-methyl-D-aspartate excitotoxicity in primary rat neuronal-glial cell cultures.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.8.959

Apolipoprotein E-derived peptides reduce CNS inflammation: implications for therapy of neurological disease

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.8.959

A novel therapeutic derived from apolipoprotein E reduces brain inflammation and improves outcome after closed head injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.8.959

Apolipoprotein E-derived peptides ameliorate clinical disability and inflammatory infiltrates into the spinal cord in a murine model of multiple sclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.8.959

The novel apolipoprotein E-based peptide COG1410 improves sensorimotor performance and reduces injury magnitude following cortical contusion injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.8.959

COG1410, a novel apolipoprotein E-based peptide, improves functional recovery in a murine model of traumatic brain injury

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.8.959

Dominant negative effects of apolipoprotein E4 revealed in transgenic models of neurodegenerative disease

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.8.959

Neuron-specific apolipoprotein e4 proteolysis is associated with increased tau phosphorylation in brains of transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.8.959

Lipid- and receptor-binding regions of apolipoprotein E4 fragments act in concert to cause mitochondrial dysfunction and neurotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.8.959

Apolipoprotein E fragments present in Alzheimer's disease brains induce neurofibrillary tangle-like intracellular inclusions in neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.8.959

Apolipoprotein E4: a causative factor and therapeutic target in neuropathology, including Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.8.959

Secretion of apolipoprotein E by brain glia requires protein prenylation and is suppressed by statins

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.8.959

Apolipoprotein (apo) E4 enhances amyloid beta peptide production in cultured neuronal cells: apoE structure as a potential therapeutic target

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.8.959

Pharmacogenetics and drug development: the path to safer and more effective drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.8.959

Modulation of astrocytic activation by arundic acid (ONO-2506) mitigates detrimental effects of the apolipoprotein E4 isoform after permanent focal ischemia in apolipoprotein E knock-in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.8.959

An apolipoprotein E-based therapeutic improves outcome and reduces Alzheimer's disease pathology following closed head injury: evidence of pharmacogenomic interaction.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.8.959

APOE genotype influences acquisition and recall following traumatic brain injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.8.959

Genetic vulnerability following traumatic brain injury: the role of apolipoprotein E.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.8.959

Association between apolipoprotein E genotype and outcome of traumatic brain injury

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.8.959

Effect of APOE polymorphisms on early responses to traumatic brain injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.8.959

The Influence of Apolipoprotein E Genotype on Outcome after Spontaneous Subarachnoid Hemorrhage: A Preliminary Study

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.8.959

Apo E in multiple sclerosis and optic neuritis: the Apo E-o4 allele is associated with progression of multiple sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.8.959

Apolipoprotein E polymorphism and neuropsychological outcome following subarachnoid haemorrhage

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.8.959

21 January 2018

Identifiers

DOI

10.2217/14622416.8.8.959

1 reference

17 August 2017

1 reference

PubMed ID

17716229