Klotho locus, metabolic traits, and serum hemoglobin in hospitalized older patients: a genetic association analysis. (Q36927446)

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5 February 2020

title

Klotho locus, metabolic traits, and serum hemoglobin in hospitalized older patients: a genetic association analysis (English)

1 reference

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5 February 2020

1 reference

1

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5 February 2020

Francesco Panza

3

1 reference

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5 February 2020

Massimiliano Copetti

5

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5 February 2020

Grazia D'Onofrio

6

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5 February 2020

Luigi Fontana

8

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5 February 2020

author name string

Davide Seripa

2

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5 February 2020

Filomena Addante

4

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5 February 2020

Fabio Pellegrini

7

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5 February 2020

Alberto Pilotto

9

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publication date

22 June 2011

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5 February 2020

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5 February 2020

volume

34

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5 February 2020

issue

4

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5 February 2020

page(s)

949-968

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Klotho deficiency is an early biomarker of renal ischemia-reperfusion injury and its replacement is protective

5 February 2020

cites work

1 reference

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Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP

29 September 2017

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29 September 2017

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Polymorphisms in the ACE and ADRB2 genes and risks of aging-associated phenotypes: the case of myocardial infarction

29 September 2017

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The FGF23-Klotho axis: endocrine regulation of phosphate homeostasis

29 September 2017

1 reference

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Evidence against a direct role of klotho in insulin resistance

29 September 2017

1 reference

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KLOTHO gene polymorphisms G-395A and C1818T are associated with low-density lipoprotein cholesterol and uric acid in Japanese hemodialysis patients

29 September 2017

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Interrelationships among HDL metabolism, aging, and atherosclerosis

29 September 2017

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KLOTHO gene polymorphisms G-395A and C1818T are associated with lipid and glucose metabolism, bone mineral density and systolic blood pressure in Japanese healthy subjects

29 September 2017

1 reference

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The frequency of Klotho KL-VS polymorphism in a large Italian population, from young subjects to centenarians, suggests the presence of specific time windows for its effect

29 September 2017

1 reference

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Altered brain gene expression profiles associated with the pathogenesis of phenylketonuria in a mouse model

29 September 2017

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Current understanding of klotho

29 September 2017

1 reference

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PPAR-gamma and aging: one link through klotho?

29 September 2017

1 reference

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Endocrine FGFs and Klothos: emerging concepts

29 September 2017

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Development and validation of a multidimensional prognostic index for one-year mortality from comprehensive geriatric assessment in hospitalized older patients

29 September 2017

1 reference

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A homozygous missense mutation in human KLOTHO causes severe tumoral calcinosis

29 September 2017

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Endocrine regulation of ageing

29 September 2017

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HDL cholesterol transport during inflammation

29 September 2017

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Advances in endocrinology of aging research, 2005-2006

29 September 2017

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Klotho converts canonical FGF receptor into a specific receptor for FGF23

29 September 2017

1 reference

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The functional "KL-VS" variant of KLOTHO is not associated with type 2 diabetes in 5028 UK Caucasians

29 September 2017

1 reference

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The quest for genetic determinants of human longevity: challenges and insights

29 September 2017

1 reference

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Sickle cell leg ulcers: associations with haemolysis and SNPs in Klotho, TEK and genes of the TGF-beta/BMP pathway

29 September 2017

1 reference

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Lipoprotein genotype and conserved pathway for exceptional longevity in humans

29 September 2017

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Modifier genes and sickle cell anemia

29 September 2017

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Regulation of fibroblast growth factor-23 signaling by klotho

29 September 2017

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Aging syndrome genes and premature coronary artery disease

29 September 2017

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Klotho gene polymorphisms are associated with osteocalcin levels but not bone density of aged postmenopausal women

29 September 2017

1 reference

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Suppression of aging in mice by the hormone Klotho

29 September 2017

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Genetic dissection and prognostic modeling of overt stroke in sickle cell anemia

29 September 2017

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Association of single nucleotide polymorphisms in klotho with priapism in sickle cell anaemia

29 September 2017

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High density lipoproteins in the intersection of diabetes mellitus, inflammation and cardiovascular disease

29 September 2017

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HDL: a recipe for longevity

29 September 2017

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Unique lipoprotein phenotype and genotype associated with exceptional longevity

29 September 2017

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KLOTHO allele status and the risk of early-onset occult coronary artery disease

29 September 2017

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HDL and arteriosclerosis: beyond reverse cholesterol transport

29 September 2017

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Association of human aging with a functional variant of klotho

29 September 2017

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Population admixture may appear to mask, change or reverse genetic effects of genes underlying complex traits

29 September 2017

1 reference

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The Mini Nutritional Assessment (MNA) for grading the nutritional state of elderly patients: presentation of the MNA, history and validation

29 September 2017

1 reference

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Biodemographic trajectories of longevity

29 September 2017

1 reference

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Identification of the human klotho gene and its two transcripts encoding membrane and secreted klotho protein

29 September 2017

1 reference

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Mutation of the mouse klotho gene leads to a syndrome resembling ageing

29 September 2017

1 reference

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Validation of the Cumulative Illness Rating Scale in a geriatric residential population

29 September 2017

1 reference

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A simple salting out procedure for extracting DNA from human nucleated cells

29 September 2017

1 reference

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Blood mononuclear cell gene expression profiles characterize the oxidant, hemolytic, and inflammatory stress of sickle cell disease

29 September 2017

1 reference

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Klotho in acute kidney injury: biomarker, therapy, or a bit of both?

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3682056

Varying expression of four genes sharing a common regulatory sequence may differentiate rheumatoid arthritis from ageing effects on the CD4(+) lymphocytes

27 June 2018

1 reference

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Association of klotho, bone morphogenic protein 6, and annexin A2 polymorphisms with sickle cell osteonecrosis

27 June 2018

1 reference

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Total, LDL, and HDL cholesterol decrease with age in older men and women. The Rancho Bernardo Study 1984-1994.

27 June 2018

1 reference

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Insulin receptor autophosphorylation and signaling is altered by modulation of membrane physical properties.

27 June 2018

1 reference

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Apolipoprotein E polymorphism in a Danish population compared to findings in 45 other study populations around the world

27 June 2018

1 reference

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A Short Portable Mental Status Questionnaire for the Assessment of Organic Brain Deficit in Elderly Patients†

27 June 2018

1 reference

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The differential effects of age on the association of KLOTHO gene polymorphisms with coronary artery disease.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3682056

Klotho is a genetic risk factor for ischemic stroke caused by cardioembolism in Korean females.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3682056

Relationship between polymorphisms G395A in promoter and C1818T in exon 4 of the KLOTHO gene with glucose metabolism and cardiovascular risk factors in Korean women.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3682056

Premature aging-like phenotype in fibroblast growth factor 23 null mice is a vitamin D-mediated process

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3682056

Klotho reduces apoptosis in experimental ischaemic acute renal failure

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3682056

Association between a functional variant of the KLOTHO gene and high-density lipoprotein cholesterol, blood pressure, stroke, and longevity

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3682056

Association of polymorphisms of the androgen receptor and klotho genes with bone mineral density in Japanese women.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3682056

False positive rates in association studies as a function of degree of stratification

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3682056

Secreted Klotho protein in sera and CSF: implication for post-translational cleavage in release of Klotho protein from cell membrane.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3682056

STUDIES OF ILLNESS IN THE AGED. THE INDEX OF ADL: A STANDARDIZED MEASURE OF BIOLOGICAL AND PSYCHOSOCIAL FUNCTION.

4 September 2018

1 reference

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Severely reduced production of klotho in human chronic renal failure kidney.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3682056

Impairment of B lymphopoiesis in precocious aging (klotho) mice.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3682056

New mice for old questions

4 September 2018

1 reference

Crossref

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Lack of replication of genetic associations with human longevity

21 January 2018

1 reference

12 December 2020

Klotho-induced insulin resistance: a blessing in disguise?

1 reference

12 December 2020

Long-lived Klotho mice: new insights into the roles of IGF-1 and insulin in aging

1 reference

12 December 2020

Toward a better understanding of Klotho

1 reference

12 December 2020

Decreased insulin production and increased insulin sensitivity in the klotho mutant mouse, a novel animal model for human aging

1 reference

12 December 2020

In vivo klotho gene delivery protects against endothelial dysfunction in multiple risk factor syndrome

1 reference

12 December 2020

Klotho gene polymorphisms associated with bone density of aged postmenopausal women

1 reference

12 December 2020

Mattresses for preventing pressure sores in geriatric patients

1 reference

12 December 2020

Assessment of older people: self-maintaining and instrumental activities of daily living

1 reference

12 December 2020

Determinants of change in total cholesterol and HDL-C with age: the Framingham Study

1 reference

12 December 2020

Downregulation of the Klotho gene in the kidney under sustained circulatory stress in rats

1 reference

12 December 2020

Klotho gene polymorphism may be a genetic risk factor for atherosclerotic coronary artery disease but not for vasospastic angina in Japanese

1 reference

12 December 2020

Klotho--a common link in physiological and rheumatoid arthritis-related aging of human CD4+ lymphocytes

1 reference

12 December 2020

Elderly Survivors with Homozygous Sickle Cell Disease

1 reference

12 December 2020

10.1007/S11357-011-9273-X

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21695423%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

1 reference

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5 February 2020

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