Integrins: signaling, disease, and therapy (Q36939598)

17 August 2017

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title

Integrins: signaling, disease, and therapy (English)

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17 August 2017

Stephan Huveneers

1

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17 August 2017

Hoa Truong

series ordinal

2

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17 August 2017

H J Danen

series ordinal

3

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17 August 2017

publication date

1 November 2007

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International Journal of Radiation Biology

17 August 2017

published in

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17 August 2017

volume

83

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17 August 2017

issue

11-12

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17 August 2017

page(s)

743-751

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Inhibition of alpha(v)beta3 integrin survival signaling enhances antiangiogenic and antitumor effects of radiotherapy

17 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1080%2F09553000701481808

Integrin alpha v beta 3 antagonist Cilengitide enhances efficacy of radiotherapy in endothelial cell and non-small-cell lung cancer models

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701481808

In vitro and in vivo effects of a cyclic peptide with affinity for the alpha(nu)beta3 integrin in human melanoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701481808

Matrix survival signaling: from fibronectin via focal adhesion kinase to c-Jun NH(2)-terminal kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701481808

Coordinate signaling by integrins and receptor tyrosine kinases in the regulation of G1 phase cell-cycle progression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701481808

Disease-modifying activity of SB 273005, an orally active, nonpeptide alphavbeta3 (vitronectin receptor) antagonist, in rat adjuvant-induced arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701481808

Disubstituted indazoles as potent antagonists of the integrin alpha(v)beta(3).

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701481808

Regulation of the expression of c-Myc by beta1 integrins in epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701481808

Novel platelet inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701481808

Integrins in development: moving on, responding to, and sticking to the extracellular matrix

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701481808

Structure and function of hemidesmosomes: more than simple adhesion complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701481808

Functional consequences of integrin gene mutations in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701481808

Requirement of vascular integrin alpha v beta 3 for angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701481808

Integrin alpha v beta 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701481808

Antiintegrin alpha v beta 3 blocks human breast cancer growth and angiogenesis in human skin

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701481808

Focal adhesions, contractility, and signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701481808

Anti-angiogenic cancer therapy based on integrin alphavbeta3 antagonism

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701481808

Improving the efficacy of antibody-based cancer therapies

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701481808

Integrin-mediated activation of MEK and mitogen-activated protein kinase is independent of Ras [corrected].

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701481808

Human endothelial cells synthesize and express an Arg-Gly-Asp-directed adhesion receptor involved in attachment to fibrinogen and von Willebrand factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701481808

Integrin-mediated cell-matrix interactions for prosurvival and antiapoptotic signaling after genotoxic injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701481808

A small molecule, orally active, alpha4beta1/alpha4beta7 dual antagonist reduces leukocyte infiltration and airway hyper-responsiveness in an experimental model of allergic asthma in Brown Norway rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701481808

Fibronectin, integrins, and growth control

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701481808

Integrin and ECM functions: roles in vertebrate development

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701481808

N-Methylated cyclic RGD peptides as highly active and selective alpha(V)beta(3) integrin antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701481808

A peptidomimetic antagonist of the alpha(v)beta3 integrin inhibits bone resorption in vitro and prevents osteoporosis in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701481808

A tumor-associated beta 1 integrin mutation that abrogates epithelial differentiation control

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701481808

Diversity does make a difference: fibroblast growth factor-heparin interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701481808

Treatment of ulcerative colitis with a humanized antibody to the alpha4beta7 integrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701481808

Tumor angiogenesis: therapeutic implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701481808

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701481808

Transmembrane crosstalk between the extracellular matrix--cytoskeleton crosstalk

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701481808

Natalizumab for active Crohn's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701481808

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701481808

Integrin signaling in epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701481808

Nanomolar small molecule inhibitors for alphav(beta)6, alphav(beta)5, and alphav(beta)3 integrins

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701481808

Disintegrins: a family of integrin inhibitory proteins from viper venoms

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701481808

Integrin signalling during tumour progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701481808

alpha(v)beta(3) Integrin antagonists as inhibitors of bone resorption

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701481808

Beta3-integrin-deficient mice are a model for Glanzmann thrombasthenia showing placental defects and reduced survival.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701481808

Anchorage-dependent ERK signaling--mechanisms and consequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701481808

What have snakes taught us about integrins?

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701481808

Integrins: bidirectional, allosteric signaling machines

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701481808

Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701481808

Small molecule alpha(v) integrin antagonists: novel anticancer agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701481808

Regulation of angiogenesis in vivo by ligation of integrin alpha5beta1 with the central cell-binding domain of fibronectin

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701481808

Tissue phenotype depends on reciprocal interactions between the extracellular matrix and the structural organization of the nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701481808

Influence of a reconstituted basement membrane and its components on casein gene expression and secretion in mouse mammary epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701481808

Integrin activation takes shape

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701481808

Integrin alphaVbeta3 contains a receptor site for resveratrol

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701481808

Lotrafiban: an oral platelet glycoprotein IIb/IIIa blocker

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701481808

Synergy between an antiangiogenic integrin alphav antagonist and an antibody-cytokine fusion protein eradicates spontaneous tumor metastases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701481808

Demonstration of mechanical connections between integrins, cytoskeletal filaments, and nucleoplasm that stabilize nuclear structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701481808

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701481808

A controlled trial of natalizumab for relapsing multiple sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701481808

Role of integrins in cancer: survey of expression patterns

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701481808

Endostatin: an endogenous inhibitor of angiogenesis and tumor growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701481808

Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701481808

The effect of Arg-Gly-Asp-containing peptides on fibrinogen and von Willebrand factor binding to platelets

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701481808

A pilot trial of Vitaxin, a humanized anti-vitronectin receptor (anti alpha v beta 3) antibody in patients with metastatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701481808

Cilengitide (EMD 121974) arrests the growth of a heavily pretreated highly vascularised head and neck tumour

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701481808

Growth factor activation of MAP kinase requires cell adhesion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701481808

Loss of beta1 integrin function results in a retardation of myogenic, but an acceleration of neuronal, differentiation of embryonic stem cells in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701481808

RGD and other recognition sequences for integrins

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701481808

Integrin signalling and tyrosine phosphorylation: just the FAKs?

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701481808

Integrins and Src: dynamic duo of adhesion signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701481808

Integrin signals, transcription factors, and monocyte differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701481808

Therapeutic antagonists and conformational regulation of integrin function

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701481808

Synthesis and SAR of N-benzoyl-L-biphenylalanine derivatives: discovery of TR-14035, a dual alpha(4)beta(7)/alpha(4)beta(1) integrin antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701481808

Inhibition of integrin alpha5beta1 function with a small peptide (ATN-161) plus continuous 5-FU infusion reduces colorectal liver metastases and improves survival in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701481808

Apoptosis of adherent cells by recruitment of caspase-8 to unligated integrins

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701481808

Contortrostatin, a snake venom disintegrin with anti-angiogenic and anti-tumor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701481808

alpha v-Integrin antagonist EMD 121974 induces apoptosis in brain tumor cells growing on vitronectin and tenascin

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701481808

A systems approach to cancer therapy. (Antioncogenics + standard cytotoxics-->mechanism(s) of interaction).

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701481808

Integrins (alpha7beta1) in muscle function and survival. Disrupted expression in merosin-deficient congenital muscular dystrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701481808

Function and interactions of integrins

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701481808

Integrin alpha 5 beta 1 expression negatively regulates cell growth: reversal by attachment to fibronectin

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701481808

Role of integrins in regulating epidermal adhesion, growth and differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701481808

beta4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701481808

Arming antibodies: prospects and challenges for immunoconjugates

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701481808

Integrin regulation of growth factor receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09553000701481808

10.1080/09553000701481808

21 January 2018

Identifiers

DOI

1 reference

17 August 2017

1 reference