Identification and functional studies of a new Nrf2 partner IQGAP1: a critical role in the stability and transactivation of Nrf2. (Q36945767)

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7 February 2020

title

Identification and functional studies of a new Nrf2 partner IQGAP1: a critical role in the stability and transactivation of Nrf2 (English)

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7 February 2020

1

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7 February 2020

David B. Sacks

3

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7 February 2020

Jong Hun Lee

4

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7

Ah-Ng Tony Kong

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7 February 2020

author name string

Eugenia Y Xu

2

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7 February 2020

Limin Shu

5

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7 February 2020

Bing Xia

6

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7 February 2020

publication date

17 September 2012

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Antioxidants & Redox Signaling

7 February 2020

published in

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7 February 2020

volume

19

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7 February 2020

issue

2

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7 February 2020

page(s)

89-101

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The nuclear cofactor RAC3/AIB1/SRC-3 enhances Nrf2 signaling by interacting with transactivation domains

7 February 2020

cites work

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29 September 2017

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29 September 2017

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Phosphorylation of Nrf2 at multiple sites by MAP kinases has a limited contribution in modulating the Nrf2-dependent antioxidant response

29 September 2017

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Nrf2:INrf2 (Keap1) signaling in oxidative stress

29 September 2017

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Direct interaction between Nrf2 and p21(Cip1/WAF1) upregulates the Nrf2-mediated antioxidant response

29 September 2017

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Small Maf proteins in mammalian gene control: mere dimerization partners or dynamic transcriptional regulators?

29 September 2017

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IQGAP1 binds Rap1 and modulates its activity

29 September 2017

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GSK-3beta acts upstream of Fyn kinase in regulation of nuclear export and degradation of NF-E2 related factor 2.

29 September 2017

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DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2

29 September 2017

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IQGAP1 in cellular signaling: bridging the GAP.

29 September 2017

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Glycogen synthase kinase-3beta inhibits the xenobiotic and antioxidant cell response by direct phosphorylation and nuclear exclusion of the transcription factor Nrf2.

29 September 2017

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Role of Nrf2 in the regulation of the Mrp2 (ABCC2) gene

29 September 2017

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Keap1 regulates the oxidation-sensitive shuttling of Nrf2 into and out of the nucleus via a Crm1-dependent nuclear export mechanism

29 September 2017

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Bach1 competes with Nrf2 leading to negative regulation of the antioxidant response element (ARE)-mediated NAD(P)H:quinone oxidoreductase 1 gene expression and induction in response to antioxidants.

29 September 2017

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Molecular mechanisms activating the Nrf2-Keap1 pathway of antioxidant gene regulation

29 September 2017

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Nrf2-Keap1 defines a physiologically important stress response mechanism

29 September 2017

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Targeted disruption of Nrf2 causes regenerative immune-mediated hemolytic anemia

29 September 2017

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PERK-dependent activation of Nrf2 contributes to redox homeostasis and cell survival following endoplasmic reticulum stress

29 September 2017

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Scaffolding of Keap1 to the actin cytoskeleton controls the function of Nrf2 as key regulator of cytoprotective phase 2 genes

29 September 2017

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Transcription factor Nrf2 is required for the constitutive and inducible expression of multidrug resistance-associated protein1 in mouse embryo fibroblasts

29 September 2017

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29 September 2017

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IQGAP1 as signal integrator: Ca2+, calmodulin, Cdc42 and the cytoskeleton

29 September 2017

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Increased protein stability as a mechanism that enhances Nrf2-mediated transcriptional activation of the antioxidant response element. Degradation of Nrf2 by the 26 S proteasome

29 September 2017

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Phosphorylation of Nrf2 at Ser-40 by protein kinase C regulates antioxidant response element-mediated transcription

29 September 2017

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Identification of the interactive interface and phylogenic conservation of the Nrf2-Keap1 system.

29 September 2017

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Induction of xenobiotic enzymes by the MAP kinase pathway and the antioxidant or electrophile response element (ARE/EpRE).

29 September 2017

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Two domains of Nrf2 cooperatively bind CBP, a CREB binding protein, and synergistically activate transcription

29 September 2017

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29 September 2017

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An important function of Nrf2 in combating oxidative stress: detoxification of acetaminophen

29 September 2017

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High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzymes and antioxidant genes

29 September 2017

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29 September 2017

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Nrf2 is essential for protection against acute pulmonary injury in mice

29 September 2017

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Nrf2, a Cap'n'Collar transcription factor, regulates induction of the heme oxygenase-1 gene

29 September 2017

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29 September 2017

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29 September 2017

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IQGAP1, a calmodulin-binding protein with a rasGAP-related domain, is a potential effector for cdc42Hs

29 September 2017

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A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure

29 September 2017

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Transcriptional regulation of the rat glutathione S-transferase Ya subunit gene. Characterization of a xenobiotic-responsive element controlling inducible expression by phenolic antioxidants

29 September 2017

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Functional interference between glycogen synthase kinase-3 beta and the transcription factor Nrf2 in protection against kainate-induced hippocampal cell death

27 June 2018

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Subcellular localization and cytoplasmic complex status of endogenous Keap1.

4 September 2018

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Participation of the calcium/calmodulin-dependent kinases in hydrogen peroxide-induced Ikappa B phosphorylation in human T lymphocytes

4 September 2018

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The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes

4 September 2018

1 reference

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Allyl sulfides from garlic suppress the in vitro proliferation of human A549 lung tumor cells.

4 September 2018

1 reference

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Cancer chemoprevention: principles and prospects.

4 September 2018

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PI3K is a key molecule in the Nrf2-mediated regulation of antioxidative proteins by hemin in human neuroblastoma cells

4 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22793650

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Regulation of human NAD(P)H:quinone oxidoreductase gene. Role of AP1 binding site contained within human antioxidant response element

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22793650

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

IQGAP1 integrates Ca2+/calmodulin and Cdc42 signaling

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22793650

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1089/ARS.2012.4586

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22793650%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22793650%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

PubMed publication ID

22793650

1 reference