SCF/{beta}-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner. (Q39606140)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21245377%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

title

SCF/{beta}-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner (English)

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20 January 2020

5

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20 January 2020

Michael McMahon

4

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20 January 2020

Antonio Cuadrado

6

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20 January 2020

Ana I Rojo

2

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20 January 2020

author name string

Patricia Rada

1

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20 January 2020

Sudhir Chowdhry

3

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20 January 2020

language of work or name

English

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publication date

18 January 2011

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Molecular and Cellular Biology

20 January 2020

published in

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20 January 2020

volume

31

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20 January 2020

issue

6

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20 January 2020

page(s)

1121-1133

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The rise of antioxidant signaling--the evolution and hormetic actions of Nrf2.

20 January 2020

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14 September 2017

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14 September 2017

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14 September 2017

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Degradation of Mcl-1 by beta-TrCP mediates glycogen synthase kinase 3-induced tumor suppression and chemosensitization

14 September 2017

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Evidence for the direct involvement of {beta}TrCP in Gli3 protein processing

14 September 2017

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Nrf2 as a target for cancer chemoprevention

14 September 2017

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BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase

14 September 2017

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Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex

14 September 2017

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14 September 2017

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The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: oxidative stress sensing by a Cul3-Keap1 ligase

14 September 2017

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Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2

14 September 2017

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Redox-regulated turnover of Nrf2 is determined by at least two separate protein domains, the redox-sensitive Neh2 degron and the redox-insensitive Neh6 degron

14 September 2017

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Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid

14 September 2017

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Distinct Cysteine Residues in Keap1 Are Required for Keap1-Dependent Ubiquitination of Nrf2 and for Stabilization of Nrf2 by Chemopreventive Agents and Oxidative Stress

14 September 2017

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Nrf2 Is a Direct PERK Substrate and Effector of PERK-Dependent Cell Survival

14 September 2017

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14 September 2017

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14 September 2017

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A complex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p

14 September 2017

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14 September 2017

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14 September 2017

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Ubiquitin-dependent c-Jun degradation in vivo is mediated by the delta domain

14 September 2017

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beta-TrCP-mediated ubiquitination and degradation of PHLPP1 are negatively regulated by Akt.

14 September 2017

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14 September 2017

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Nrf2 enhances cell proliferation and resistance to anticancer drugs in human lung cancer

14 September 2017

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14 September 2017

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A mutation of Keap1 found in breast cancer impairs its ability to repress Nrf2 activity

14 September 2017

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beta-Trcp mediates ubiquitination and degradation of the erythropoietin receptor and controls cell proliferation

14 September 2017

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Glycogen synthase kinase-3beta inhibits the xenobiotic and antioxidant cell response by direct phosphorylation and nuclear exclusion of the transcription factor Nrf2.

14 September 2017

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14 September 2017

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14 September 2017

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Functional interference between glycogen synthase kinase-3 beta and the transcription factor Nrf2 in protection against kainate-induced hippocampal cell death

25 September 2017

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GSK-3beta down-regulates the transcription factor Nrf2 after oxidant damage: relevance to exposure of neuronal cells to oxidative stress.

21 August 2018

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Dimerization of substrate adaptors can facilitate cullin-mediated ubiquitylation of proteins by a "tethering" mechanism: a two-site interaction model for the Nrf2-Keap1 complex.

21 August 2018

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In vitro reconstitution of SCF substrate ubiquitination with purified proteins

21 August 2018

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The FWD1/beta-TrCP-mediated degradation pathway establishes a 'turning off switch' of a Cdc42 guanine nucleotide exchange factor, FGD1.

21 August 2018

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Ceramide and reactive oxygen species generated by H2O2 induce caspase-3-independent degradation of Akt/protein kinase B.

21 August 2018

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Inhibition of PKB/Akt1 by C2-ceramide involves activation of ceramide-activated protein phosphatase in PC12 cells.

21 August 2018

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The transcription factor Nrf2 as a new therapeutic target in Parkinson's disease

21 August 2018

1 reference

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Regulated proteolysis of Xom mediates dorsoventral pattern formation during early Xenopus development

2 December 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21245377

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

UV-induced degradation of securin is mediated by SKP1-CUL1- TrCP E3 ubiquitin ligase

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21245377

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1128/MCB.01204-10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21245377%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21245377%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

PubMed publication ID

21245377

1 reference