How telomeres are replicated (Q36948200)

17 August 2017

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title

How telomeres are replicated (English)

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17 August 2017

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Eric Gilson

1

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PubMed ID

17885666

17 August 2017

Vincent Géli

series ordinal

2

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17 August 2017

1 October 2007

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Nature Reviews Molecular Cell Biology

17 August 2017

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17 August 2017

8

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17 August 2017

10

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17 August 2017

825-838

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https://scigraph.springernature.com/pub.10.1038/nrm2259

17 August 2017

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cites work

Loss of a yeast telomere: arrest, recovery, and chromosome loss.

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TRF2 Protects Human Telomeres from End-to-End Fusions

31 March 2020

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Shelterin: the protein complex that shapes and safeguards human telomeres

31 March 2020

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The telomerase cycle: normal and pathological aspects

31 March 2020

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Identification of a specific telomere terminal transferase activity in Tetrahymena extracts

31 March 2020

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Replication of the extrachromosomal ribosomal RNA genes of Tetrahymena thermophilia

31 March 2020

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Structural and temporal analysis of telomere replication in yeast

31 March 2020

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Saccharomyces Rrm3p, a 5' to 3' DNA helicase that promotes replication fork progression through telomeric and subtelomeric DNA.

31 March 2020

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Anatomy and dynamics of DNA replication fork movement in yeast telomeric regions

31 March 2020

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Semi-conservative DNA replication through telomeres requires Taz1

31 March 2020

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DNA primase and the replication of the telomeres in Oxytricha nova

31 March 2020

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Interactions between telomerase and primase physically link the telomere and chromosome replication machinery

31 March 2020

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Replication proteins influence the maintenance of telomere length and telomerase protein stability

31 March 2020

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Telomeric chromatin modulates replication timing near chromosome ends

31 March 2020

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Completion of replication map of Saccharomyces cerevisiae chromosome III.

31 March 2020

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Telomeric proteins regulate episomal maintenance of Epstein-Barr virus origin of plasmid replication

31 March 2020

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A topological mechanism for TRF2-enhanced strand invasion

31 March 2020

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The DNA damage machinery and homologous recombination pathway act consecutively to protect human telomeres

31 March 2020

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Replication dynamics of the yeast genome.

31 March 2020

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Position effect at S. cerevisiae telomeres: reversible repression of Pol II transcription

31 March 2020

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A position effect on the time of replication origin activation in yeast

31 March 2020

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Control of replication timing by a transcriptional silencer.

31 March 2020

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Limitations of silencing at native yeast telomeres

31 March 2020

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Chromosomal landscape of nucleosome-dependent gene expression and silencing in yeast.

31 March 2020

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Ku complex controls the replication time of DNA in telomere regions.

31 March 2020

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The Ctf18 RFC-like complex positions yeast telomeres but does not specify their replication time.

31 March 2020

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Cell cycle-dependent establishment of a late replication program

31 March 2020

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DNA replication forks pause at silent origins near the HML locus in budding yeast

31 March 2020

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Asynchronous replication timing of telomeres at opposite arms of mammalian chromosomes

31 March 2020

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Origin usage during euplotes ribosomal DNA amplification

31 March 2020

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Normal human telomeres are not late replicating

31 March 2020

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Replication timing of human telomeric DNA and other repetitive sequences analyzed by fluorescence in situ hybridization and flow cytometry

31 March 2020

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Position effect of human telomeric repeats on replication timing

31 March 2020

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Progressive cis-inhibition of telomerase upon telomere elongation.

31 March 2020

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Telomere length homeostasis is achieved via a switch between telomerase- extendible and -nonextendible states.

31 March 2020

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Early replication of short telomeres in budding yeast

31 March 2020

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Regulation of DNA-replication origins during cell-cycle progression

31 March 2020

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A Mec1- and Rad53-dependent checkpoint controls late-firing origins of DNA replication

31 March 2020

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Genomic mapping of single-stranded DNA in hydroxyurea-challenged yeasts identifies origins of replication

31 March 2020

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Defective telomere lagging strand synthesis in cells lacking WRN helicase activity.

31 March 2020

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Telomere instability in a human tumor cell line expressing a dominant-negative WRN protein

31 March 2020

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Unwinding the molecular basis of the Werner syndrome

31 March 2020

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Telomere shortening exposes functions for the mouse Werner and Bloom syndrome genes

31 March 2020

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Essential role of limiting telomeres in the pathogenesis of Werner syndrome

31 March 2020

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Unexpected twist: harnessing the energy in positive supercoils to control telomere resolution.

31 March 2020

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To fire or not to fire: origin activation in Saccharomyces cerevisiae ribosomal DNA.

31 March 2020

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The S. cerevisiae Rrm3p DNA helicase moves with the replication fork and affects replication of all yeast chromosomes

31 March 2020

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Suppression of spontaneous genome rearrangements in yeast DNA helicase mutants

31 March 2020

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The Werner syndrome helicase and exonuclease cooperate to resolve telomeric D loops in a manner regulated by TRF1 and TRF2

31 March 2020

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Long G tails at both ends of human chromosomes suggest a C strand degradation mechanism for telomere shortening

31 March 2020

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Cell cycle-regulated generation of single-stranded G-rich DNA in the absence of telomerase

31 March 2020

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All gene-sized DNA molecules in four species of hypotrichs have the same terminal sequence and an unusual 3' terminus

31 March 2020

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The generation of proper constitutive G-tails on yeast telomeres is dependent on the MRX complex

31 March 2020

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Human telomeres have different overhang sizes at leading versus lagging strands

31 March 2020

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Processing of telomeric DNA ends requires the passage of a replication fork

31 March 2020

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G-strand overhangs on telomeres in telomerase-deficient mouse cells

31 March 2020

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In vitro reconstitution of the end replication problem

31 March 2020

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DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1

31 March 2020

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Regulation of telomere elongation by the cyclin-dependent kinase CDK1.

31 March 2020

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DNA degradation at unprotected telomeres in yeast is regulated by the CDK1 (Cdc28/Clb) cell-cycle kinase

31 March 2020

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DNA breaks are masked by multiple Rap1 binding in yeast: implications for telomere capping and telomerase regulation.

31 March 2020

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Late S phase-specific recruitment of Mre11 complex triggers hierarchical assembly of telomere replication proteins in Saccharomyces cerevisiae.

31 March 2020

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Apollo, an Artemis-related nuclease, interacts with TRF2 and protects human telomeres in S phase

31 March 2020

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The Apollo 5' exonuclease functions together with TRF2 to protect telomeres from DNA repair

31 March 2020

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Accumulation of single-stranded DNA and destabilization of telomeric repeats in yeast mutant strains carrying a deletion of RAD27.

31 March 2020

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The function of DNA polymerase alpha at telomeric G tails is important for telomere homeostasis

31 March 2020

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Fission yeast Dna2 is required for generation of the telomeric single-strand overhang

31 March 2020

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Eukaryotic DNA Polymerases

31 March 2020

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Pol12, the B subunit of DNA polymerase alpha, functions in both telomere capping and length regulation

31 March 2020

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CDC17: an essential gene that prevents telomere elongation in yeast

31 March 2020

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Saccharomyces telomeres acquire single-strand TG1-3 tails late in S phase

31 March 2020

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The Ku Heterodimer Performs Separable Activities at Double-Strand Breaks and Chromosome Termini

31 March 2020

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Vertebrate POT1 restricts G-overhang length and prevents activation of a telomeric DNA damage checkpoint but is dispensable for overhang protection

31 March 2020

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Are mouse telomeres going to pot?

31 March 2020

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ERCC1/XPF removes the 3' overhang from uncapped telomeres and represses formation of telomeric DNA-containing double minute chromosomes

31 March 2020

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DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion

31 March 2020

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Lagging strand replication proteins in genome stability and DNA repair

31 March 2020

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Evidence suggesting that Pif1 helicase functions in DNA replication with the Dna2 helicase/nuclease and DNA polymerase delta

31 March 2020

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Saccharomyces cerevisiae RNase H(35) functions in RNA primer removal during lagging-strand DNA synthesis, most efficiently in cooperation with Rad27 nuclease

31 March 2020

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RNase H2 of Saccharomyces cerevisiae is a complex of three proteins

31 March 2020

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Synthesis of the mammalian telomere lagging strand in vitro

31 March 2020

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Coordinate regulation of G- and C strand length during new telomere synthesis

31 March 2020

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Generation of Telomeric G Strand Overhangs Involves Both G and C Strand Cleavage

31 March 2020

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Telomere-end processing the terminal nucleotides of human chromosomes

31 March 2020

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POT1 protects telomeres from a transient DNA damage response and determines how human chromosomes end

31 March 2020

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T-loop assembly in vitro involves binding of TRF2 near the 3' telomeric overhang

31 March 2020

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The basic domain of TRF2 directs binding to DNA junctions irrespective of the presence of TTAGGG repeats

31 March 2020

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Strand-Specific Postreplicative Processing of Mammalian Telomeres

31 March 2020

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Homologous recombination generates T-loop-sized deletions at human telomeres

31 March 2020

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The clustering of telomeres and colocalization with Rap1, Sir3, and Sir4 proteins in wild-type Saccharomyces cerevisiae

31 March 2020

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Chromosome dynamics in the yeast interphase nucleus

31 March 2020

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Cell cycle restriction of telomere elongation

31 March 2020

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Telomerase-mediated telomere addition in vivo requires DNA primase and DNA polymerases alpha and delta.

31 March 2020

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Est1p as a cell cycle-regulated activator of telomere-bound telomerase

31 March 2020

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RPA regulates telomerase action by providing Est1p access to chromosome ends

31 March 2020

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Delivery of yeast telomerase to a DNA break depends on the recruitment functions of Cdc13 and Est1

31 March 2020

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Proteasome-dependent degradation of Est1p regulates the cell cycle-restricted assembly of telomerase in Saccharomyces cerevisiae

31 March 2020

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S. cerevisiae Tel1p and Mre11p are required for normal levels of Est1p and Est2p telomere association.

31 March 2020

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Ku interacts with telomerase RNA to promote telomere addition at native and broken chromosome ends

31 March 2020

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Cell cycle-dependent regulation of yeast telomerase by Ku.

31 March 2020

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Est1 and Cdc13 as comediators of telomerase access

31 March 2020

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Cdc13p: a single-strand telomeric DNA-binding protein with a dual role in yeast telomere maintenance

31 March 2020

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Cdc13 delivers separate complexes to the telomere for end protection and replication

31 March 2020

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Cdc13 cooperates with the yeast Ku proteins and Stn1 to regulate telomerase recruitment

31 March 2020

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Saccharomyces cerevisiae telomerase is an Sm small nuclear ribonucleoprotein particle

31 March 2020

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A bulged stem tethers Est1p to telomerase RNA in budding yeast

31 March 2020

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The function of a stem-loop in telomerase RNA is linked to the DNA repair protein Ku.

31 March 2020

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A phylogenetically based secondary structure for the yeast telomerase RNA.

31 March 2020

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Yeast telomerase RNA: a flexible scaffold for protein subunits

31 March 2020

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A miniature yeast telomerase RNA functions in vivo and reconstitutes activity in vitro

31 March 2020

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RPA-like proteins mediate yeast telomere function

31 March 2020

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Telomere formation by rap1p binding site arrays reveals end-specific length regulation requirements and active telomeric recombination

31 March 2020

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The yeast Pif1p helicase removes telomerase from telomeric DNA.

31 March 2020

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The finger subdomain of yeast telomerase cooperates with Pif1p to limit telomere elongation

31 March 2020

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A protein-counting mechanism for telomere length regulation in yeast.

31 March 2020

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Circular chromosome formation in a fission yeast mutant defective in two ATM homologues.

31 March 2020

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Altering telomere structure allows telomerase to act in yeast lacking ATM kinases

31 March 2020

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TEL1, a gene involved in controlling telomere length in S. cerevisiae, is homologous to the human ataxia telangiectasia gene.

31 March 2020

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Sudden telomere lengthening triggers a Rad53-dependent checkpoint in Saccharomyces cerevisiae

31 March 2020

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Telomerase and Tel1p preferentially associate with short telomeres in S. cerevisiae.

31 March 2020

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Increased association of telomerase with short telomeres in yeast.

31 March 2020

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Subtelomeric proteins negatively regulate telomere elongation in budding yeast

31 March 2020

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Subtelomeric factors antagonize telomere anchoring and Tel1-independent telomere length regulation

31 March 2020

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Telomere end-binding proteins control the formation of G-quadruplex DNA structures in vivo

31 March 2020

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DNA binding features of human POT1: a nonamer 5'-TAGGGTTAG-3' minimal binding site, sequence specificity, and internal binding to multimeric sites

31 March 2020

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POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex

31 March 2020

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Human POT1 facilitates telomere elongation by telomerase

31 March 2020

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Rescue of an hTERT mutant defective in telomere elongation by fusion with hPot1

31 March 2020

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Human protection of telomeres 1 (POT1) is a negative regulator of telomerase activity in vitro

31 March 2020

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Switching human telomerase on and off with hPOT1 protein in vitro

31 March 2020

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TIN2 mediates functions of TRF2 at human telomeres

31 March 2020

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PTOP interacts with POT1 and regulates its localization to telomeres

31 March 2020

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TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres

31 March 2020

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A critical role for TPP1 and TIN2 interaction in high-order telomeric complex assembly

31 March 2020

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A dynamic molecular link between the telomere length regulator TRF1 and the chromosome end protector TRF2

31 March 2020

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OB(oligonucleotide/oligosaccharide binding)-fold: common structural and functional solution for non-homologous sequences

31 March 2020

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The POT1-TPP1 telomere complex is a telomerase processivity factor

31 March 2020

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TPP1 is a homologue of ciliate TEBP-beta and interacts with POT1 to recruit telomerase

31 March 2020

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Targeting assay to study the cis functions of human telomeric proteins: evidence for inhibition of telomerase by TRF1 and for activation of telomere degradation by TRF2

31 March 2020

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POT1 as a terminal transducer of TRF1 telomere length control

31 March 2020

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Chromatin structure of the molecular ends of Oxytricha macronuclear DNA: phased nucleosomes and a telomeric complex

31 March 2020

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Saccharomyces telomeres assume a non-nucleosomal chromatin structure

31 March 2020

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Telomere maintenance, function and evolution: the yeast paradigm.

31 March 2020

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The epigenetic regulation of mammalian telomeres

31 March 2020

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Telomere position effect in human cells

31 March 2020

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Human telomeric position effect is determined by chromosomal context and telomeric chromatin integrity

31 March 2020

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A human telomeric protein

31 March 2020

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Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2

31 March 2020

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Telomeric localization of TRF2, a novel human telobox protein

31 March 2020

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Mammalian telomeres end in a large duplex loop

31 March 2020

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POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substrates

31 March 2020

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Human POT1 disrupts telomeric G-quadruplexes allowing telomerase extension in vitro

31 March 2020

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TRF1 promotes parallel pairing of telomeric tracts in vitro

31 March 2020

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A RAP1/TRF2 complex inhibits nonhomologous end-joining at human telomeric DNA ends

31 March 2020

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Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines

31 March 2020

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A novel telomere structure in a human alternative lengthening of telomeres cell line

31 March 2020

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Break-induced replication and recombinational telomere elongation in yeast

31 March 2020

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Telomere maintenance without telomerase

31 March 2020

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Two retrotransposons maintain telomeres in Drosophila

31 March 2020

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Endonuclease-independent LINE-1 retrotransposition at mammalian telomeres

31 March 2020

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Human replication protein A unfolds telomeric G-quadruplexes

31 March 2020

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Telomere repeat binding factor 2 interacts with base excision repair proteins and stimulates DNA synthesis by DNA polymerase beta

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRM2259

1 reference

PubMed ID

17885666

Dimensions Publication ID

17 August 2017

0 references

1 reference

PubMed ID

17885666