Phase I study of the Hedgehog pathway inhibitor IPI-926 in adult patients with solid tumors (Q36959835)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23575478%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

title

Phase I study of the Hedgehog pathway inhibitor IPI-926 in adult patients with solid tumors (English)

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28 February 2020

5

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28 February 2020

Charles Rudin

16

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28 February 2020

author name string

Antonio Jimeno

1

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28 February 2020

Glen J Weiss

2

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28 February 2020

Wilson H Miller

3

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28 February 2020

Anne Lynne S Chang

6

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28 February 2020

Joi Dunbar

7

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28 February 2020

Shannon Devens

8

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28 February 2020

Kerrie Faia

9

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28 February 2020

Georgios Skliris

10

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28 February 2020

Jeff Kutok

11

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28 February 2020

Karl D Lewis

12

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28 February 2020

Raoul Tibes

13

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28 February 2020

William H Sharfman

14

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28 February 2020

Robert W Ross

15

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28 February 2020

Scott Gettinger

4

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28 February 2020

language of work or name

English

0 references

publication date

10 April 2013

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28 February 2020

published in

Clinical Cancer Research

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28 February 2020

volume

19

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28 February 2020

issue

10

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28 February 2020

page(s)

2766-2774

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Inhibition of the hedgehog pathway targets the tumor-associated stroma in pancreatic cancer

28 February 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3694426

Mechanisms of resistance to crizotinib in patients with ALK gene rearranged non-small cell lung cancer.

29 September 2017

1 reference

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A crucial requirement for Hedgehog signaling in small cell lung cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3694426

Phase I trial of hedgehog pathway inhibitor vismodegib (GDC-0449) in patients with refractory, locally advanced or metastatic solid tumors.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3694426

Approaches to phase 1 clinical trial design focused on safety, efficiency, and selected patient populations: a report from the clinical trial design task force of the national cancer institute investigational drug steering committee

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3694426

Inhibition of the hedgehog pathway in advanced basal-cell carcinoma

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3694426

Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3694426

A direct pancreatic cancer xenograft model as a platform for cancer stem cell therapeutic development.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3694426

Basal cell carcinomas: attack of the hedgehog

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3694426

Hedgehog signaling maintains a tumor stem cell compartment in multiple myeloma

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3694426

Modulation of hair growth with small molecule agonists of the hedgehog signaling pathway

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3694426

Hedgehog signalling in prostate regeneration, neoplasia and metastasis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3694426

Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3694426

Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3694426

Hedgehog signaling in animal development: paradigms and principles

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3694426

New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3694426

Basal cell carcinomas in mice arise from hair follicle stem cells and multiple epithelial progenitor populations.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3694426

Basal cell carcinomas arise from hair follicle stem cells in Ptch1(+/-) mice

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3694426

Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: a new paradigm for combination therapy in solid cancers

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3694426

The role of the hedgehog/patched signaling pathway in epithelial stem cell proliferation: from fly to human

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3694426

Pretreatment EGFR T790M mutation and BRCA1 mRNA expression in erlotinib-treated advanced non-small-cell lung cancer patients with EGFR mutations.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3694426

Ligand-dependent activation of the hedgehog pathway in glioma progenitor cells.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3694426

Medulloblastoma growth inhibition by hedgehog pathway blockade

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3694426

10.1158/1078-0432.CCR-12-3654

4 September 2018

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23575478%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

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28 February 2020

1 reference