Chk2 phosphorylation of survivin-DeltaEx3 contributes to a DNA damage-sensing checkpoint in cancer. (Q36963631)

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1 February 2020

title

Chk2 phosphorylation of survivin-DeltaEx3 contributes to a DNA damage-sensing checkpoint in cancer (English)

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6

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Valentina Vaira

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Silvano Bosari

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13

Dario C Altieri

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author name string

Alessia Lopergolo

1

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Michele Tavecchio

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Sofia Lisanti

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Jagadish C Ghosh

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Takehiko Dohi

5

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Nobuhiko Tanigawa

9

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Domenico Delia

10

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Andrew V Kossenkov

11

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Louise C Showe

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language of work or name

English

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publication date

14 May 2012

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volume

72

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issue

13

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page(s)

3251-3259

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Inactivation of chk2 and mus81 leads to impaired lymphocytes development, reduced genomic instability, and suppression of cancer

1 February 2020

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29 September 2017

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Survivin may enhance DNA double-strand break repair capability by up-regulating Ku70 in human KB cells

29 September 2017

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Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2.

29 September 2017

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Survivin: key regulator of mitosis and apoptosis and novel target for cancer therapeutics

29 September 2017

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Gene expression of survivin and its spliced isoforms associated with proliferation and aggressive phenotypes of prostate cancer

29 September 2017

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ATM and the Mre11 complex combine to recognize and signal DNA double-strand breaks

29 September 2017

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29 September 2017

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Alternative splice variants of survivin as potential targets in cancer

29 September 2017

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Forced expression of survivin-2B abrogates mitotic cells and induces mitochondria-dependent apoptosis by blockade of tubulin polymerization and modulation of Bcl-2, Bax, and survivin

29 September 2017

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The survivin isoform survivin-3B is cytoprotective and can function as a chromosomal passenger complex protein

29 September 2017

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Characterisation of the anti-apoptotic function of survivin-DeltaEx3 during TNFalpha-mediated cell death

29 September 2017

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29 September 2017

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The Survivin-Crm1 interaction is essential for chromosomal passenger complex localization and function

29 September 2017

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Dissecting the role of endothelial SURVIVIN DeltaEx3 in angiogenesis

29 September 2017

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Defective Mre11-dependent activation of Chk2 by ataxia telangiectasia mutated in colorectal carcinoma cells in response to replication-dependent DNA double strand breaks

29 September 2017

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Molecular analysis of survivin isoforms: evidence that alternatively spliced variants do not play a role in mitosis

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Survivin enhances radiation resistance in primary human glioblastoma cells via caspase-independent mechanisms

29 September 2017

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29 September 2017

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Characterization of an anti-apoptotic glycoprotein encoded by Kaposi's sarcoma-associated herpesvirus which resembles a spliced variant of human survivin

29 September 2017

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Homology-directed dna repair, mitomycin-c resistance, and chromosome stability is restored with correction of a Brca1 mutation

29 September 2017

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A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage

29 September 2017

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XRCC3 promotes homology-directed repair of DNA damage in mammalian cells

29 September 2017

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The clinical significance of splice variants and subcellular localisation of survivin in non-small cell lung cancers

29 September 2017

1 reference

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Survivin inhibition and DNA double-strand break repair: a molecular mechanism to overcome radioresistance in glioblastoma.

27 June 2018

1 reference

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In vivo expression of survivin and its splice variant survivin-2B: impact on clinical outcome in acute myeloid leukemia.

4 September 2018

1 reference

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Differential subcellular localization of functionally divergent survivin splice variants.

4 September 2018

1 reference

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Survivin exists in immunochemically distinct subcellular pools and is involved in spindle microtubule function

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3695608

CRM1-mediated nuclear export determines the cytoplasmic localization of the antiapoptotic protein Survivin

4 September 2018

1 reference

12 December 2020

Identification of a novel nucleolar localization signal and a degradation signal in Survivin-deltaEx3: a potential link between nucleolus and protein degradation

1 reference

12 December 2020

Multicenter phase II trial of YM155, a small-molecule suppressor of survivin, in patients with advanced, refractory, non-small-cell lung cancer

1 reference

12 December 2020

Radiosensitizing effect of YM155, a novel small-molecule survivin suppressant, in non-small cell lung cancer cell lines

1 reference

12 December 2020

10.1158/0008-5472.CAN-11-4035

Identifiers

DOI

1 reference

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1 February 2020

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1 February 2020

PubMed publication ID

22586065

1 reference