Human P2Y(6) receptor: molecular modeling leads to the rational design of a novel agonist based on a unique conformational preference. (Q36974147)

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14 January 2020

title

Human P2Y(6) receptor: molecular modeling leads to the rational design of a novel agonist based on a unique conformational preference (English)

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14 January 2020

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1

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14 January 2020

Kenneth A. Jacobson

8

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14 January 2020

author name string

Bhalchandra V Joshi

2

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14 January 2020

Savitri Maddileti

3

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14 January 2020

Liaman Mamedova

4

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14 January 2020

Maria J Gonzalez-Moa

5

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Victor E Marquez

6

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T Kendall Harden

7

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language of work or name

English

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publication date

1 December 2005

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Journal of Medicinal Chemistry

14 January 2020

published in

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14 January 2020

volume

48

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14 January 2020

issue

26

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14 January 2020

page(s)

8108-8111

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Human cytidine deaminase: a three-dimensional homology model of a tetrameric metallo-enzyme inferred from the crystal structure of a distantly related dimeric homologue

14 January 2020

cites work

1 reference

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Overview of the P2 receptors

29 September 2017

1 reference

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Essential role for the second extracellular loop in C5a receptor activation

29 September 2017

1 reference

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Architecture of P2Y nucleotide receptors: structural comparison based on sequence analysis, mutagenesis, and homology modeling.

29 September 2017

1 reference

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Nucleotide analogues containing 2-oxa-bicyclo[2.2.1]heptane and l-alpha-threofuranosyl ring systems: interactions with P2Y receptors

29 September 2017

1 reference

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2-Chloro N(6)-methyl-(N)-methanocarba-2'-deoxyadenosine-3',5'-bisphosphate is a selective high affinity P2Y(1) receptor antagonist

29 September 2017

1 reference

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Methanocarba modification of uracil and adenine nucleotides: high potency of Northern ring conformation at P2Y1, P2Y2, P2Y4, and P2Y11 but not P2Y6 receptors

29 September 2017

1 reference

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Methanocarba analogues of purine nucleosides as potent and selective adenosine receptor agonists.

29 September 2017

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The role of amino acids in extracellular loops of the human P2Y1 receptor in surface expression and activation processes.

29 September 2017

1 reference

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Role of the extracellular loops of G protein-coupled receptors in ligand recognition: a molecular modeling study of the human P2Y1 receptor.

29 September 2017

1 reference

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A mutational analysis of residues essential for ligand recognition at the human P2Y1 receptor.

29 September 2017

1 reference

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Nucleosides with a twist. Can fixed forms of sugar ring pucker influence biological activity in nucleosides and oligonucleotides?

29 September 2017

1 reference

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Purinergic P2Y6 receptors induce Ca2+ and CFTR dependent Cl- secretion in mouse trachea

27 June 2018

1 reference

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Molecular characterization of a purified 5-HT4 receptor: a structural basis for drug efficacy

4 September 2018

1 reference

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Structure, energetics, and dynamics of lipid-protein interactions: A molecular dynamics study of the gramicidin A channel in a DMPC bilayer

4 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16366591

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1021/JM050911P

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14 January 2020

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14 January 2020

PubMed publication ID

16366591

1 reference