Understanding B-cell tolerance through the use of immunoglobulin transgenic models (Q36974265)

17 August 2017

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title

Understanding B-cell tolerance through the use of immunoglobulin transgenic models (English)

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17 August 2017

Kirthi Raman Kumar

1

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PubMed ID

17943232

17 August 2017

Chandra Mohan

series ordinal

2

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PubMed ID

17943232

17 August 2017

language of work or name

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1 January 2008

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17 August 2017

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17 August 2017

40

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17 August 2017

3

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17 August 2017

208-223

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https://scigraph.springernature.com/pub.10.1007/s12026-007-8008-7

17 August 2017

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cites work

Impaired clearance of apoptotic cells induces the activation of autoreactive anti-Sm marginal zone and B-1 B cells

1 reference

https://api.crossref.org/works/10.1007%2FS12026-007-8008-7

Low-affinity anti-Smith antigen B cells are regulated by anergy as opposed to developmental arrest or differentiation to B-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-007-8008-7

Early preplasma cells define a tolerance checkpoint for autoreactive B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-007-8008-7

Tolerance to DNA in (NZB x NZW)F1 mice that inherit an anti-DNA V(H) as a conventional micro H chain transgene but not as a V(H) knock-in transgene

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12026-007-8008-7

CD95 (Fas)-dependent elimination of self-reactive B cells upon interaction with CD4+ T cells.

21 January 2018

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12 December 2020

Autoreactive B cell regulation: peripheral induction of developmental arrest by lupus-associated autoantigens.

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12 December 2020

Editing disease-associated autoantibodies

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12 December 2020

Lupus-specific antiribonucleoprotein B cell tolerance in nonautoimmune mice is maintained by differentiation to B-1 and governed by B cell receptor signaling thresholds

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12 December 2020

Activation and anergy in bone marrow B cells of a novel immunoglobulin transgenic mouse that is both hapten specific and autoreactive.

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12 December 2020

Light chain editing in kappa-deficient animals: a potential mechanism of B cell tolerance

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12 December 2020

Resistance to CpG DNA-induced autoimmunity through tolerogenic B cell antigen receptor ERK signaling

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12 December 2020

Loci predisposing to autoimmunity in MRL-Fas lpr and C57BL/6-Faslpr mice

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12 December 2020

MRL-lpr/lpr mice exhibit a defect in maintaining developmental arrest and follicular exclusion of anti-double-stranded DNA B cells

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12 December 2020

Impaired early B cell tolerance in patients with rheumatoid arthritis.

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12 December 2020

Ig-α Cytoplasmic Truncation Renders Immature B Cells More Sensitive to Antigen Contact

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12 December 2020

Secondary heavy chain rearrangement: a mechanism for generating anti-double-stranded DNA B cells

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12 December 2020

Production of high affinity autoantibodies in autoimmune New Zealand Black/New Zealand white F1 mice targeted with an anti-DNA heavy chain

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12 December 2020

Role of Bim and other Bcl-2 family members in autoimmune and degenerative diseases

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12 December 2020

Positive versus negative signaling by lymphocyte antigen receptors

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12 December 2020

A checkpoint for autoreactivity in human IgM+ memory B cell development

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12 December 2020

The fate of self-reactive B cells depends primarily on the degree of antigen receptor engagement and availability of T cell help.

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12 December 2020

Receptor editing is the main mechanism of B cell tolerance toward membrane antigens

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12 December 2020

Immunoglobulin M and D antigen receptors are both capable of mediating B lymphocyte activation, deletion, or anergy after interaction with specific antigen

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12 December 2020

Chronic graft-versus-host in Ig knockin transgenic mice abrogates B cell tolerance in anti-double-stranded DNA B cells

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12 December 2020

Developmental regulation of B lymphocyte immune tolerance compartmentalizes clonal selection from receptor selection.

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12 December 2020

A rheumatoid factor transgenic mouse model of autoantibody regulation

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12 December 2020

The role of complement in the development of systemic lupus erythematosus

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12 December 2020

Effects of the lpr mutation on elimination and inactivation of self-reactive B cells

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12 December 2020

Maternal Ig mediates neonatal tolerance in rheumatoid factor transgenic mice but tolerance breaks down in adult mice

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12 December 2020

Spontaneous B cell hyperactivity in autoimmune-prone MRL mice

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12 December 2020

Autoantigen-specific B cell activation in Fas-deficient rheumatoid factor immunoglobulin transgenic mice

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12 December 2020

The central and multiple roles of B cells in lupus pathogenesis

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12 December 2020

Protein tyrosine phosphatase 1C negatively regulates antigen receptor signaling in B lymphocytes and determines thresholds for negative selection.

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12 December 2020

An intrinsic B cell defect is required for the production of autoantibodies in the lpr model of murine systemic autoimmunity

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12 December 2020

B-cell anergy: from transgenic models to naturally occurring anergic B cells?

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12 December 2020

Enforced Bcl-2 expression inhibits antigen-mediated clonal elimination of peripheral B cells in an antigen dose-dependent manner and promotes receptor editing in autoreactive, immature B cells

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12 December 2020

Induction of autoimmunity in a transgenic model of B cell receptor peripheral tolerance: changes in coreceptors and B cell receptor-induced tyrosine-phosphoproteins

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12 December 2020

Systemic lupus erythematosus

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12 December 2020

Editors and editing of anti-DNA receptors.

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12 December 2020

Regulation of anti-double-stranded DNA B cells in nonautoimmune mice: localization to the T-B interface of the splenic follicle

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12 December 2020

Protein kinase Cδ controls self-antigen-induced B-cell tolerance

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12 December 2020

Reduced life span of anergic self-reactive B cells in a double-transgenic model

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12 December 2020

Repression of B7.2 on self-reactive B cells is essential to prevent proliferation and allow Fas-mediated deletion by CD4(+) T cells

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12 December 2020

Cutting edge: lupus susceptibility interval Sle3/5 confers responsiveness to prolactin in C57BL/6 mice

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12 December 2020

The site and stage of anti-DNA B-cell deletion.

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12 December 2020

Analysis of Lyn/CD22 double-deficient B cells in vivo demonstrates Lyn- and CD22-independent pathways affecting BCR regulation and B cell survival

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12 December 2020

Deletion and editing of B cells that express antibodies to DNA

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12 December 2020

Elimination of self-reactive B lymphocytes proceeds in two stages: arrested development and cell death.

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12 December 2020

The protooncogene MYC can break B cell tolerance

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12 December 2020

Anergic self-reactive B cells present self antigen and respond normally to CD40-dependent T-cell signals but are defective in antigen-receptor-mediated functions.

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12 December 2020

Efficient peripheral clonal elimination of B lymphocytes in MRL/lpr mice bearing autoantibody transgenes

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12 December 2020

How self-tolerance and the immunosuppressive drug FK506 prevent B-cell mitogenesis.

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12 December 2020

Expansion or elimination of B cells in vivo: dual roles for CD40- and Fas (CD95)-ligands modulated by the B cell antigen receptor.

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12 December 2020

Regulation of B-lymphocyte negative and positive selection by tyrosine phosphatase CD45

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12 December 2020

Competition for follicular niches excludes self-reactive cells from the recirculating B-cell repertoire.

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12 December 2020

In vivo assessment of the relative contributions of deletion, anergy, and editing to B cell self-tolerance

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12 December 2020

Receptor editing can lead to allelic inclusion and development of B cells that retain antibodies reacting with high avidity autoantigens

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12 December 2020

Receptor editing: an approach by autoreactive B cells to escape tolerance

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12 December 2020

Peripheral B cell receptor editing may promote the production of high-affinity autoantibodies in CD22-deficient mice.

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12 December 2020

Self-reactive B lymphocytes overexpressing Bcl-xL escape negative selection and are tolerized by clonal anergy and receptor editing.

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12 December 2020

Induction of self-tolerance in T cells but not B cells of transgenic mice expressing little self antigen.

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12 December 2020

A critical role for complement in maintenance of self-tolerance

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12 December 2020

Antigen-induced exclusion from follicles and anergy are separate and complementary processes that influence peripheral B cell fate

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12 December 2020

VL-VH expression by monoclonal antibodies recognizing avian lysozyme

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12 December 2020

Immunoglobulin heavy chain gene replacement: a mechanism of receptor editing

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12 December 2020

Entry of B cell receptor into signaling domains is inhibited in tolerant B cells.

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12 December 2020

B lymphocytes from the autoimmune-prone mouse strain MLR/lpr manifest an intrinsic defect in tetraparental MRL/lpr in equilibrium DBA/2 chimeras

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12 December 2020

Loss of the pro-apoptotic BH3-only Bcl-2 family member Bim inhibits BCR stimulation-induced apoptosis and deletion of autoreactive B cells

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12 December 2020

Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognizing membrane-bound antigens

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12 December 2020

Autoreactive B cells in lupus-prone New Zealand black mice exhibit aberrant survival and proliferation in the presence of self-antigen in vivo

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12 December 2020

Chronic GVH prevents anergy in bone marrow self-reactive B cells: a selective increase in post-endoplasmic reticulum processing and trafficking to the cell surface of autoreactive IgM receptors

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12 December 2020

Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice.

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12 December 2020

Autoantibodies in chronic graft versus host result from cognate T-B interactions

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12 December 2020

High affinity rheumatoid factor transgenic B cells are eliminated in normal mice

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12 December 2020

The origin of anti-nuclear antibodies in bcl-2 transgenic mice.

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12 December 2020

Maintenance of B cell anergy requires constant antigen receptor occupancy and signaling

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12 December 2020

Characterization of anti-single-stranded DNA B cells in a non-autoimmune background

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12 December 2020

Transgenic mice and analysis of B-cell tolerance

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12 December 2020

Autoreactive B cells in the marginal zone that express dual receptors

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12 December 2020

Novel roles for Lyn in B cell migration and lipopolysaccharide responsiveness revealed using anti-double-stranded DNA Ig transgenic mice

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12 December 2020

Autoimmune NZB/NZW F1 mice utilize B cell receptor editing for generating high-affinity anti-dsDNA autoantibodies from low-affinity precursors

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12 December 2020

Polygenic autoimmune traits: Lyn, CD22, and SHP-1 are limiting elements of a biochemical pathway regulating BCR signaling and selection

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12 December 2020

The regulation of lupus-associated autoantibodies: immunoglobulin transgenic models

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12 December 2020

Fas/Fas ligand deficiency results in altered localization of anti-double-stranded DNA B cells and dendritic cells

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12 December 2020

Transgenic models of tolerance and autoimmunity: with special reference to systemic lupus erythematosus

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12 December 2020

Ig light chain receptor editing in anergic B cells

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12 December 2020

B cell receptor-independent stimuli trigger immunoglobulin (Ig) class switch recombination and production of IgG autoantibodies by anergic self-reactive B cells.

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12 December 2020

The inhibitory Fcγ receptor modulates autoimmunity by limiting the accumulation of immunoglobulin G+ anti-DNA plasma cells

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12 December 2020

Different sensitivity to receptor editing of B cells from mice hemizygous or homozygous for targeted Ig transgenes

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12 December 2020

Anti-DNA B cells in MRL/lpr mice show altered differentiation and editing pattern

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12 December 2020

B cell depletion therapy in autoimmune diseases

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12 December 2020

Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations

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12 December 2020

Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors

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12 December 2020

Different nuclear signals are activated by the B cell receptor during positive versus negative signaling.

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12 December 2020

Loss of the proapoptotic protein, Bim, breaks B cell anergy

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12 December 2020

Role of Syk in B-cell development and antigen-receptor signaling

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12 December 2020

Predominant autoantibody production by early human B cell precursors

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12 December 2020

Breakdown of self-tolerance in anergic B lymphocytes.

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12 December 2020

Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes

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12 December 2020

Peripheral deletion of self-reactive B cells

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12 December 2020

Receptor editing for better or for worse

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12 December 2020

Promotion and prevention of autoimmunity by B lymphocytes.

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12 December 2020

Induction of self-tolerance in mature peripheral B lymphocytes

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12 December 2020

The calcineurin phosphatase complex modulates immunogenic B cell responses

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12 December 2020

Characterization of anergic anti-DNA B cells: B cell anergy is a T cell-independent and potentially reversible process

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12 December 2020

Regulation of anti-DNA B cells in recombination-activating gene-deficient mice

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12 December 2020

Altered selection processes of B lymphocytes in autoimmune NZB/W mice, despite intact central tolerance against DNA

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12 December 2020

Analysis of central B cell tolerance in autoimmune-prone MRL/lpr mice bearing autoantibody transgenes

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12 December 2020

Receptor editing in self-reactive bone marrow B cells

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12 December 2020

Self-antigen does not accelerate immature B cell apoptosis, but stimulates receptor editing as a consequence of developmental arrest.

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12 December 2020

Persistent expression of autoantibodies in SLE patients in remission

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12 December 2020

Silencing of autoreactive B cells by anergy: a fresh perspective.

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12 December 2020

CD19-regulated signaling thresholds control peripheral tolerance and autoantibody production in B lymphocytes

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12 December 2020

Germinal center exclusion of autoreactive B cells is defective in human systemic lupus erythematosus.

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12 December 2020

Resting and anergic B cells are defective in CD28-dependent costimulation of naive CD4+ T cells.

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12 December 2020

B cell deletion, anergy, and receptor editing in "knock in" mice targeted with a germline-encoded or somatically mutated anti-DNA heavy chain

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12 December 2020

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12 December 2020

Regulation of autoreactive anti-IgG (rheumatoid factor) B cells in normal and autoimmune mice

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12 December 2020

Light chain editing generates polyreactive antibodies in chronic graft-versus-host reaction.

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12 December 2020

Involvement of NFAT1 in B cell self-tolerance

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12 December 2020

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12 December 2020

Lpr and gld: single gene models of systemic autoimmunity and lymphoproliferative disease

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12 December 2020

Lupus susceptibility genes may breach tolerance to DNA by impairing receptor editing of nuclear antigen-reactive B cells

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12 December 2020

Development and selection of edited B cells in B6.56R mice

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12 December 2020

TLR4, TLR9 and MyD88 are not required for the positive selection of autoreactive B cells into the primary repertoire

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12 December 2020

Defective B cell tolerance checkpoints in systemic lupus erythematosus

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12 December 2020

Regulation of B cell tolerance by the lupus susceptibility gene Ly108.

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12 December 2020

Expression of anti-DNA immunoglobulin transgenes in non-autoimmune mice

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12 December 2020

CD5 maintains tolerance in anergic B cells

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12 December 2020

Essential role of membrane cholesterol in accelerated BCR internalization and uncoupling from NF-kappa B in B cell clonal anergy

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12 December 2020

Light chain replacement: a new model for antibody gene rearrangement

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12 December 2020

Anti-Sm B cell differentiation in Ig transgenic MRL/Mp-lpr/lpr mice: altered differentiation and an accelerated response

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12 December 2020

Cr2, a candidate gene in the murine Sle1c lupus susceptibility locus, encodes a dysfunctional protein

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12 December 2020

Excess BAFF rescues self-reactive B cells from peripheral deletion and allows them to enter forbidden follicular and marginal zone niches.

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12 December 2020

Evolution of autoantibody responses via somatic hypermutation outside of germinal centers

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12 December 2020

10.1007/S12026-007-8008-7

Identifiers

DOI

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17 August 2017

1 reference

PubMed ID

17943232