Induction of intrachromosomal homologous recombination in human cells by raltitrexed, an inhibitor of thymidylate synthase. (Q36981985)

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10 January 2020

title

Induction of intrachromosomal homologous recombination in human cells by raltitrexed, an inhibitor of thymidylate synthase (English)

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10 January 2020

6

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author name string

Barbara Criscuolo Waldman

1

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10 January 2020

Yibin Wang

2

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10 January 2020

Kasturi Kilaru

3

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10 January 2020

Zhengguan Yang

4

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10 January 2020

Alaukik Bhasin

5

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10 January 2020

Alan S Waldman

7

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publication date

21 July 2008

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10 January 2020

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10 January 2020

volume

7

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10 January 2020

issue

10

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10 January 2020

page(s)

1624-1635

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Uracil incorporation into genomic DNA does not predict toxicity caused by chemotherapeutic inhibition of thymidylate synthase.

10 January 2020

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Accurate homologous recombination is a prominent double-strand break repair pathway in mammalian chromosomes and is modulated by mismatch repair protein Msh2.

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29 September 2017

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Determination of apoptosis, uracil incorporation, DNA strand breaks, and sister chromatid exchanges under conditions of thymidylate deprivation in a model of BER deficiency

29 September 2017

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Incorporation of dUMP into DNA is a major source of spontaneous DNA damage, while excision of uracil is not required for cytotoxicity of fluoropyrimidines in mouse embryonic fibroblasts

29 September 2017

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Involvement of base excision repair in response to therapy targeted at thymidylate synthase

29 September 2017

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Modulation of error-prone double-strand break repair in mammalian chromosomes by DNA mismatch repair protein Mlh1

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Pathways for mitotic homologous recombination in mammalian cells

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Anticancer Antifolates: Current Status and Future Directions

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5-Fluorouracil: mechanisms of action and clinical strategies

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Thymine metabolism and thymineless death in prokaryotes and eukaryotes

29 September 2017

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Cell cycle effects of antifolate antimetabolites: implications for cytotoxicity and cytostasis

29 September 2017

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Thymine starvation-induced structural changes in Escherichia coli DNA. Detection by pulsed field gel electrophoresis and evidence for involvement of homologous recombination

29 September 2017

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Methotrexate-induced misincorporation of uracil into DNA.

29 September 2017

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Induction of mitotic recombination in yeast by starvation for thymine nucleotides

29 September 2017

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Nucleotide sequence of the thymidine kinase gene of herpes simplex virus type 1

29 September 2017

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Thymineless death and genetic events in mammalian cells

29 September 2017

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Induction, by thymidylate stress, of genetic recombination as evidenced by deletion of a transferred genetic marker in mouse FM3A cells

29 September 2017

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Ratio of 2'-deoxyadenosine-5'-triphosphate/thymidine-5'-triphosphate influences the commitment of human colon carcinoma cells to thymineless death.

29 September 2017

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Cellular heterogeneity in DNA damage and growth inhibition induced by ICI D1694, thymidylate synthase inhibitor, using single cell assays

29 September 2017

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Induction of resistance to fluorodeoxyuridine cytotoxicity and DNA damage in human tumor cells by expression of Escherichia coli deoxyuridinetriphosphatase

29 September 2017

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Recombination-deficient mutations and thymineless death in Escherichia coli K12: reciprocal effects of recBC and recF and indifference of recA mutations.

27 June 2018

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Induction of intrachromosomal recombination in yeast by inhibition of thymidylate biosynthesis

27 June 2018

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Thymineless death in Escherichia coli mutants deficient in the RecF recombination pathway

27 June 2018

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ICI D1694, a quinazoline antifolate thymidylate synthase inhibitor that is a potent inhibitor of L1210 tumor cell growth in vitro and in vivo: a new agent for clinical study

27 June 2018

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Thymidylate stress induces homologous recombination activity in mammalian cells

27 June 2018

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Raltitrexed increases tumorigenesis as a single agent yet exhibits anti-tumor synergy with 5-fluorouracil in ApcMin/+ mice

27 June 2018

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Expression of uracil DNA glycosylase (UDG) does not affect cellular sensitivity to thymidylate synthase (TS) inhibition

4 September 2018

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Isolation and genetic characterization of a thymineless death-resistant mutant of Escherichia coli K12: identification of a new mutation (recQ1) that blocks the RecF recombination pathway.

4 September 2018

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DNA damage and p53 induction do not cause ZD1694-induced cell cycle arrest in human colon carcinoma cells

4 September 2018

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12 December 2020

Mating-type switching in yeast is induced by thymine nucleotide depletion

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12 December 2020

Inhibition of thymidylate biosynthesis induces mitotic unequal sister chromatid recombination in Saccharomyces cerevisiae

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12 December 2020

Chromosome breakage induced by thymidylate stress in thymidylate synthase-negative mutants of mouse FM3A cells

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12 December 2020

Deoxyribonucleoside triphosphate imbalance. 5-Fluorodeoxyuridine-induced DNA double strand breaks in mouse FM3A cells and the mechanism of cell death

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12 December 2020

Accumulation of DNA strand breaks during thymineless death in thymidylate synthase-negative mutants of mouse FM3A cells

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12 December 2020

Thymidylate stress and sister chromatid exchanges

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12 December 2020

10.1016/J.DNAREP.2008.06.006

Identifiers

DOI

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10 January 2020

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10 January 2020

PubMed publication ID

18603020

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