Uracil incorporation into genomic DNA does not predict toxicity caused by chemotherapeutic inhibition of thymidylate synthase. (Q40066683)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17942376%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

title

Uracil incorporation into genomic DNA does not predict toxicity caused by chemotherapeutic inhibition of thymidylate synthase (English)

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9 January 2020

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3

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9 January 2020

author name string

Yuhong Luo

series ordinal

1

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9 January 2020

Mike Walla

series ordinal

2

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9 January 2020

publication date

17 October 2007

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9 January 2020

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9 January 2020

volume

7

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9 January 2020

issue

2

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9 January 2020

page(s)

162-169

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Human base excision repair complex is physically associated to DNA replication and cell cycle regulatory proteins

9 January 2020

cites work

1 reference

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5-Fluorouracil incorporated into DNA is excised by the Smug1 DNA glycosylase to reduce drug cytotoxicity

22 September 2017

1 reference

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Methylating agents and DNA repair responses: Methylated bases and sources of strand breaks

22 September 2017

1 reference

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Chk1-dependent slowing of S-phase progression protects DT40 B-lymphoma cells against killing by the nucleoside analogue 5-fluorouracil.

22 September 2017

1 reference

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Linking uracil base excision repair and 5-fluorouracil toxicity in yeast

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2258137

Uracil DNA glycosylase is dispensable for human immunodeficiency virus type 1 replication and does not contribute to the antiviral effects of the cytidine deaminase Apobec3G.

22 September 2017

1 reference

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AP endonuclease deficiency results in extreme sensitivity to thymidine deprivation

22 September 2017

1 reference

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Determination of apoptosis, uracil incorporation, DNA strand breaks, and sister chromatid exchanges under conditions of thymidylate deprivation in a model of BER deficiency

22 September 2017

1 reference

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DNA mismatch repair-dependent response to fluoropyrimidine-generated damage.

22 September 2017

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Incorporation of dUMP into DNA is a major source of spontaneous DNA damage, while excision of uracil is not required for cytotoxicity of fluoropyrimidines in mouse embryonic fibroblasts

22 September 2017

1 reference

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5-fluoro-2'-deoxyuridine-induced cdc25A accumulation correlates with premature mitotic entry and clonogenic death in human colon cancer cells

22 September 2017

1 reference

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Small interfering RNA-mediated suppression of dUTPase sensitizes cancer cell lines to thymidylate synthase inhibition

22 September 2017

1 reference

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Involvement of base excision repair in response to therapy targeted at thymidylate synthase

22 September 2017

1 reference

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5-Fluorouracil: mechanisms of action and clinical strategies

22 September 2017

1 reference

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Uracil in DNA--occurrence, consequences and repair

22 September 2017

1 reference

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Human MRE11 is inactivated in mismatch repair-deficient cancers

22 September 2017

1 reference

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Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress

22 September 2017

1 reference

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The ability to accumulate deoxyuridine triphosphate and cellular response to thymidylate synthase (TS) inhibition

22 September 2017

1 reference

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Biphasic kinetics of the human DNA repair protein MED1 (MBD4), a mismatch-specific DNA N-glycosylase

22 September 2017

1 reference

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Uracil-DNA glycosylase (UNG)-deficient mice reveal a primary role of the enzyme during DNA replication

22 September 2017

1 reference

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Post-replicative base excision repair in replication foci

22 September 2017

1 reference

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dUTP pyrophosphatase is an essential enzyme in Saccharomyces cerevisiae

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2258137

Crystal structure of human uracil-DNA glycosylase in complex with a protein inhibitor: protein mimicry of DNA

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2258137

Multiple mutant of Escherichia coli synthesizing virtually thymineless DNA during limited growth

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2258137

Deoxyuridine triphosphatase (dUTPase) expression and sensitivity to the thymidylate synthase (TS) inhibitor ZD9331

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2258137

Mechanism and pharmacological specificity of dUTPase-mediated protection from DNA damage and cytotoxicity in human tumor cells

25 September 2017

1 reference

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Ratio of 2'-deoxyadenosine-5'-triphosphate/thymidine-5'-triphosphate influences the commitment of human colon carcinoma cells to thymineless death.

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2258137

Induction of resistance to fluorodeoxyuridine cytotoxicity and DNA damage in human tumor cells by expression of Escherichia coli deoxyuridinetriphosphatase

25 September 2017

1 reference

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A naturally occurring variation in thymidylate synthase structure is associated with a reduced response to 5-fluoro-2'-deoxyuridine in a human colon tumor cell line.

17 June 2018

1 reference

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Uracil-DNA glycosylase inhibitor gene of bacteriophage PBS2 encodes a binding protein specific for uracil-DNA glycosylase

17 June 2018

1 reference

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Differential roles of checkpoint kinase 1, checkpoint kinase 2, and mitogen-activated protein kinase-activated protein kinase 2 in mediating DNA damage-induced cell cycle arrest: implications for cancer therapy.

17 June 2018

1 reference

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Uracil in DNA, determined by an improved assay, is increased when deoxynucleosides are added to folate-deficient cultured human lymphocytes

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2258137

Expression of uracil DNA glycosylase (UDG) does not affect cellular sensitivity to thymidylate synthase (TS) inhibition

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2258137

dUTPase and uracil-DNA glycosylase are central modulators of antifolate toxicity in Saccharomyces cerevisiae.

20 August 2018

1 reference

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Separating substrate recognition from base hydrolysis in human thymine DNA glycosylase by mutational analysis

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2258137

DNA damage and p53 induction do not cause ZD1694-induced cell cycle arrest in human colon carcinoma cells

20 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17942376

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Fluorodeoxyuridine modulates cellular expression of the DNA base excision repair enzyme uracil-DNA glycosylase

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17942376

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.DNAREP.2007.09.001

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17942376%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17942376%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

PubMed publication ID

17942376

1 reference