Alzheimer's brains harbor somatic mtDNA control-region mutations that suppress mitochondrial transcription and replication (Q36986848)

17 August 2017

Alzheimer's brains harbor somatic mtDNA control-region mutations that suppress mitochondrial transcription and replication (English)

1 reference

17 August 2017

0 references

2

M Flint Beal

1 reference

17 August 2017

Pinar E Coskun

1

1 reference

PMCID

490002

17 August 2017

Douglas C Wallace

series ordinal

3

1 reference

PMCID

490002

17 August 2017

language of work or name

English

0 references

publication date

9 July 2004

1 reference

Proceedings of the National Academy of Sciences of the United States of America

17 August 2017

1 reference

17 August 2017

101

1 reference

17 August 2017

10726-10731

1 reference

17 August 2017

29

1 reference

Mitochondrial abnormalities in cybrid cell models of sporadic Alzheimer's disease worsen with passage in culture

17 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=490002

Differences in assembly or stability of complex I and other mitochondrial OXPHOS complexes in inherited complex I deficiency

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=490002

Effects of purifying and adaptive selection on regional variation in human mtDNA.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=490002

Coupled reductions in brain oxidative phosphorylation and synaptic function can be quantified and staged in the course of Alzheimer disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=490002

Mitochondrial Polymorphisms Significantly Reduce the Risk of Parkinson Disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=490002

Control region mtDNA variants: longevity, climatic adaptation, and a forensic conundrum

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=490002

Strikingly higher frequency in centenarians and twins of mtDNA mutation causing remodeling of replication origin in leukocytes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=490002

Amyloid-beta and tau serve antioxidant functions in the aging and Alzheimer brain

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=490002

Role of mitochondrial dysfunction in Alzheimer's disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=490002

Alzheimer's disease and oxygen radicals: new insights

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=490002

Frequent intracellular clonal expansions of somatic mtDNA mutations: significance and mechanisms

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=490002

Alzheimer's disease: role of aging in pathogenesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=490002

Cytochrome c oxidase and mitochondrial F1F0-ATPase (ATP synthase) activities in platelets and brain from patients with Alzheimer's disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=490002

Oxidative processes in the brain and non-neuronal tissues as biomarkers of Alzheimer's disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=490002

High aggregate burden of somatic mtDNA point mutations in aging and Alzheimer's disease brain

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=490002

Muscle-specific mutations accumulate with aging in critical human mtDNA control sites for replication

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=490002

Impact of apoE deficiency on oxidative insults and antioxidant levels in the brain

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=490002

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=490002

Tracing European founder lineages in the Near Eastern mtDNA pool

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=490002

Molecular genetics of Alzheimer's disease: the role of beta-amyloid and the presenilins.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=490002

Cloning of neuronal mtDNA variants in cultured cells by synaptosome fusion with mtDNA-less cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=490002

Aging-dependent large accumulation of point mutations in the human mtDNA control region for replication

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=490002

Cell-by-cell scanning of whole mitochondrial genomes in aged human heart reveals a significant fraction of myocytes with clonally expanded deletions

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=490002

Decreased brain protein levels of cytochrome oxidase subunits in Alzheimer's disease and in hereditary spinocerebellar ataxia disorders: a nonspecific change?

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=490002

The mtDNA-encoded ND6 subunit of mitochondrial NADH dehydrogenase is essential for the assembly of the membrane arm and the respiratory function of the enzyme

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=490002

Mitochondrial DNA maintenance in vertebrates

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=490002

The tRNA(Gln) 4336 mitochondrial DNA variant is not a high penetrance mutation which predisposes to dementia before the age of 75 years.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=490002

Apolipoprotein E allele-specific antioxidant activity and effects on cytotoxicity by oxidative insults and beta-amyloid peptides

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=490002

Morphological, biochemical, and genetic support for an apolipoprotein E effect on microtubular metabolism

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=490002

A mitochondrial DNA clone is associated with increased risk for Alzheimer disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=490002

Point mutations of the mtDNA control region in normal and neurodegenerative human brains

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=490002

Mitochondrial DNA sequence analysis of four Alzheimer's and Parkinson's disease patients.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=490002

The role of cytochrome c oxidase deficient hippocampal neurones in Alzheimer's disease

27 June 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0403649101

Cytochrome c oxidase is decreased in Alzheimer's disease platelets

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0403649101

Decreased hippocampal metabolic activity in Alzheimer patients is not reflected in the immunoreactivity of cytochrome oxidase subunits.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0403649101

Mitochondrial enzyme expression in the hippocampus in relation to Alzheimer-type pathology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0403649101

Mitochondrial DNA variants observed in Alzheimer disease and Parkinson disease patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0403649101

Association of the mitochondrial tRNA(A4336G) mutation with Alzheimer's and Parkinson's diseases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0403649101

No association found between Alzheimer's disease and a mitochondrial tRNA glutamine gene variant.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0403649101

Low mutational burden of individual acquired mitochondrial DNA mutations in brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0403649101

Is mitochondrial DNA depletion involved in Alzheimer's disease?

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0403649101

Decreased expression of nuclear and mitochondrial DNA-encoded genes of oxidative phosphorylation in association neocortex in Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0403649101

Morphological, Biochemical, and Genetic Support for an Apolipoprotein E Effect on Microtubular Metabolisma

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0403649101

Oxidative insults are associated with apolipoprotein E genotype in Alzheimer's disease brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0403649101

ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0403649101

Energy hypometabolism in posterior cingulate cortex of Alzheimer's patients: superficial laminar cytochrome oxidase associated with disease duration.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=490002

Cortical cytochrome oxidase activity is reduced in Alzheimer's disease.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=490002

The Aβ Peptide of Alzheimer's Disease Directly Produces Hydrogen Peroxide through Metal Ion Reduction†

4 September 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0403649101

Marked changes in mitochondrial DNA deletion levels in Alzheimer brains

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15247418

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Phylogenetic analysis of the mitochondrial genome indicates significant differences between patients with Alzheimer disease and controls in a French-Canadian founder population

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15247418

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.0403649101

1 reference

17 August 2017

0 references

1 reference

17 August 2017

1 reference

PMCID

490002