Hydrocortisone stimulates neurite outgrowth from mouse retinal explants by modulating macroglial activity (Q36991716)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22395888%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

title

Hydrocortisone stimulates neurite outgrowth from mouse retinal explants by modulating macroglial activity (English)

1 reference

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25 January 2020

1 reference

1 reference

1

1 reference

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25 January 2020

author name string

Cynthia Berlinicke

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22395888%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

Donald J Zack

series ordinal

3

1 reference

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25 January 2020

Robert W Nickells

series ordinal

4

1 reference

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25 January 2020

language of work or name

English

0 references

publication date

24 April 2012

1 reference

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Investigative Ophthalmology Visual Science

25 January 2020

published in

1 reference

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25 January 2020

volume

53

1 reference

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25 January 2020

issue

4

1 reference

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25 January 2020

page(s)

2046-2061

1 reference

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Histone H4 deacetylation plays a critical role in early gene silencing during neuronal apoptosis

25 January 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704200

Prolonged blockade of VEGF receptors does not damage retinal photoreceptors or ganglion cells

29 September 2017

1 reference

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Neurotrophin roles in retinal ganglion cell survival: lessons from rat glaucoma models

29 September 2017

1 reference

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Role of retinal glial cells in neurotransmitter uptake and metabolism

29 September 2017

1 reference

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Astrocytes as gate-keepers in optic nerve regeneration--a mini-review

29 September 2017

1 reference

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Regeneration of axons in the visual system.

29 September 2017

1 reference

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The role of macrophages in optic nerve regeneration

29 September 2017

1 reference

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Up-regulation of brain-derived neurotrophic factor by application of fibroblast growth factor-2 to the cut optic nerve is important for long-term survival of retinal ganglion cells.

29 September 2017

1 reference

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Molecular and cell-based approaches for neuroprotection in glaucoma

29 September 2017

1 reference

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ROCK inhibition and CNTF interact on intrinsic signalling pathways and differentially regulate survival and regeneration in retinal ganglion cells

29 September 2017

1 reference

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Ganglion cell death in glaucoma: from mice to men.

29 September 2017

1 reference

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Vascular endothelial growth factor-A is a survival factor for retinal neurons and a critical neuroprotectant during the adaptive response to ischemic injury.

29 September 2017

1 reference

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From ocular hypertension to ganglion cell death: a theoretical sequence of events leading to glaucoma

29 September 2017

1 reference

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Dominant inheritance of retinal ganglion cell resistance to optic nerve crush in mice

29 September 2017

1 reference

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Pigment epithelium-derived factor protects retinal ganglion cells

29 September 2017

1 reference

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Multiple neuroprotective mechanisms of minocycline in autoimmune CNS inflammation

29 September 2017

1 reference

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International Union of Pharmacology. LXV. The pharmacology and classification of the nuclear receptor superfamily: glucocorticoid, mineralocorticoid, progesterone, and androgen receptors

29 September 2017

1 reference

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Müller cells in the healthy and diseased retina

29 September 2017

1 reference

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Müller Cells as a source of brain-derived neurotrophic factor in the retina: noradrenaline upregulates brain-derived neurotrophic factor levels in cultured rat Müller cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704200

Susceptibility to neurodegeneration in a glaucoma is modified by Bax gene dosage

29 September 2017

1 reference

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Glaucoma: thinking in new ways-a rôle for autonomous axonal self-destruction and other compartmentalised processes?

29 September 2017

1 reference

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Bone morphogenetic proteins promote neurite outgrowth in retinal ganglion cells.

29 September 2017

1 reference

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Cellular mechanisms associated with spontaneous and ciliary neurotrophic factor-cAMP-induced survival and axonal regeneration of adult retinal ganglion cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704200

Müller cell response to laser-induced increase in intraocular pressure in rats

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704200

Insertion of the beta Geo promoter trap into the Fem1c gene of ROSA3 mice

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704200

The molecular biology of retinal ganglion cell death: caveats and controversies

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704200

Glutamate stimulates neurotrophin expression in cultured Müller cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704200

Microglia-Müller glia cell interactions control neurotrophic factor production during light-induced retinal degeneration.

29 September 2017

1 reference

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Retinal glutamate transporter changes in experimental glaucoma and after optic nerve transection in the rat.

29 September 2017

1 reference

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Retinal ganglion cells do not extend axons by default: promotion by neurotrophic signaling and electrical activity

29 September 2017

1 reference

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The role of astrocytes in axonal regeneration in the mammalian CNS.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704200

Inactivation of the glial fibrillary acidic protein gene, but not that of vimentin, improves neuronal survival and neurite growth by modifying adhesion molecule expression

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704200

A new mathematical model for relative quantification in real-time RT-PCR

29 September 2017

1 reference

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Protection of ganglion cells in experimental glaucoma by retinal laser photocoagulation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704200

Neuroprotection by glutamine synthetase.

29 September 2017

1 reference

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Fine tuning of glutamate uptake and degradation in glial cells: common transcriptional regulation of GLAST1 and GS.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704200

Glial fibrillary acidic protein (GFAP): modulation by growth factors and its implication in astrocyte differentiation.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704200

Glial cell line-derived neurotrophic factor (GDNF) promotes the survival of axotomized retinal ganglion cells in adult rats: comparison to and combination with brain-derived neurotrophic factor (BDNF).

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704200

Functions of the two glutamate transporters GLAST and GLT-1 in the retina

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704200

In vivo neurotrophic effects of GDNF on axotomized retinal ganglion cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704200

Glutamine synthetase protects against neuronal degeneration in injured retinal tissue

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704200

Developmental changes in the expression and compartmentalization of the glucocorticoid receptor in embryonic retina

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704200

Identification of L-methionine-S-sulfoximine as the convulsant isomer of methionine sulfoximine

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704200

Growth of a rat neuroblastoma cell line in serum-free supplemented medium

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704200

Methionine sulfoximine, an inhibitor of glutamine synthetase, lowers brain glutamine and glutamate in a mouse model of ALS.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704200

Müller glial cells express nestin coupled with glial fibrillary acidic protein in experimentally induced glaucoma in the rat retina

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704200

Ciliary neurotrophic factor protects retinal ganglion cells from axotomy-induced apoptosis via modulation of retinal glia in vivo

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704200

The mineralocorticoid receptor in rodent retina: ontogeny and molecular identity.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704200

Changes in Thy1 gene expression associated with damaged retinal ganglion cells

27 June 2018

1 reference

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Regenerative capacity of retinal ganglion cells in mammals

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704200

Retinal axon divergence in the optic chiasm: midline cells are unaffected by the albino mutation.

27 June 2018

1 reference

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Intravitreal injections of neurotrophic factors support the survival of axotomized retinal ganglion cells in adult rats in vivo.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704200

Molecular basis for differential expression of glutamine synthetase in retina glia and neurons

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704200

Retinal ganglion cell survival and neurite regeneration in vitro after cell death period are dependent upon target derived trophic factor and retinal glial factor(s).

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704200

Retinal and epiretinal glia--an immunohistochemical study.

27 June 2018

1 reference

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Proliferation of glial-derived cells in defined media

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704200

Studies on the mechanism of inhibition of glutamine synthetase by methionine sulfoximine

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704200

Species-specificity of corticosteroid receptors in hamster and rat brains.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704200

NCAM-induced neurite outgrowth depends on binding of calmodulin to NCAM and on nuclear import of NCAM and fak fragments.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704200

Neuroprotective and axon growth-promoting effects following inflammatory stimulation on mature retinal ganglion cells in mice depend on ciliary neurotrophic factor and leukemia inhibitory factor

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704200

Activated retinal glia promote neurite outgrowth of retinal ganglion cells via apolipoprotein E.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704200

Exogenous CNTF stimulates axon regeneration of retinal ganglion cells partially via endogenous CNTF.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704200

Müller glia factors induce survival and neuritogenesis of peripheral and central neurons

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704200

Different factors promote axonal regeneration of adult rat retinal ganglion cells after lens injury and intravitreal peripheral nerve grafting

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704200

Astrocyte-derived CNTF switches mature RGCs to a regenerative state following inflammatory stimulation.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704200

AAV-mediated expression of CNTF promotes long-term survival and regeneration of adult rat retinal ganglion cells

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704200

Minocycline delays death of retinal ganglion cells in experimental glaucoma and after optic nerve transection.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704200

Synergistic action of brain-derived neurotrophic factor and lens injury promotes retinal ganglion cell survival, but leads to optic nerve dystrophy in vivo

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704200

Neurotrophic factor synergy is required for neuronal survival and disinhibited axon regeneration after CNS injury

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704200

Multiple signaling pathways regulate FGF-2-induced retinal ganglion cell neurite extension and growth cone guidance

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704200

Effects of minocycline and tetracycline on retinal ganglion cell survival after axotomy

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704200

Effect of glaucoma on the retinal glutamate/glutamine cycle activity

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704200

Different aspects of gliosis in retinal Muller glia can be induced by CNTF, insulin, and FGF2 in the absence of damage

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704200

The outgrowth response of the axons of developing and regenerating rat retinal ganglion cells in vitro to neurotrophin treatment

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704200

Intravitreal injections of neurotrophic factors and forskolin enhance survival and axonal regeneration of axotomized beta ganglion cells in cat retina

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704200

Mitochondrial localization of glucocortocoid receptor in glial (Müller) cells in the salamander retina.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704200

Glutamine synthetase enhances the clearance of extracellular glutamate by the neural retina

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704200

Amacrine-signaled loss of intrinsic axon growth ability by retinal ganglion cells

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704200

Expression of glial fibrillary acidic protein and glutamine synthetase by Müller cells after optic nerve damage and intravitreal application of brain-derived neurotrophic factor

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704200

A non-excitatory paradigm of glutamate toxicity

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704200

Basic fibroblast growth factor: a potential inhibitor of glutamine synthetase expression in injured neural tissue

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704200

Glial fibrillary acidic protein: regulation by hormones, cytokines, and growth factors

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704200

Survival and differentiation of purified retinal ganglion cells in a chemically defined microenvironment.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704200

Transcriptional regulation of glial fibrillary acidic protein by corticosterone in rat astrocytes in vitro is influenced by the duration of time in culture and by astrocyte-neuron interactions

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704200

Characterization of the signaling interactions that promote the survival and growth of developing retinal ganglion cells in culture

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704200

Adult rat retinal glia in vitro: effects of in vivo crush-activation on glia proliferation and permissiveness for regenerating retinal ganglion cell axons

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3704200

An immunohistochemical study of neuronal and glial cell reactions in retinae of rats with experimental glaucoma

4 September 2018

1 reference

12 December 2020

Upregulation of ciliary neurotrophic factor in reactive Müller cells in the rat retina following optic nerve transection

1 reference

12 December 2020

Cortisol promotes survival and regeneration of axotomised retinal ganglion cells and enhances effects of aurintricarboxylic acid

1 reference

12 December 2020

Expression of CNTF in Müller cells of the rat retina after pressure-induced ischemia

1 reference

12 December 2020

The mineralocorticoid hormone receptor and action in the eye

1 reference

12 December 2020

Glial reactivity in the retina of adult rats

1 reference

12 December 2020

Cell to cell contacts control the transcription activity of the glucocorticoid receptor

1 reference

12 December 2020

Lens injury stimulates axon regeneration in the mature rat optic nerve

1 reference

12 December 2020

Expression of ciliary neurotrophic factor activated by retinal Müller cells in eyes with NMDA- and kainic acid-induced neuronal death

1 reference

12 December 2020

Up-regulated CNTF plays a protective role for retrograde degeneration in the axotomized rat retina

1 reference

12 December 2020

Chemotactic effect of ciliary neurotrophic factor on macrophages in retinal ganglion cell survival and axonal regeneration

1 reference

12 December 2020

Immunohistochemical distribution of 11beta-hydroxysteroid dehydrogenase in human eye

1 reference

12 December 2020

Basic fibroblast growth factor applied to the optic nerve after injury increases long-term cell survival in the frog retina

1 reference

12 December 2020

Brain-derived neurotrophic factor-mediated neuroprotection of adult rat retinal ganglion cells in vivo does not exclusively depend on phosphatidyl-inositol-3'-kinase/protein kinase B signaling

1 reference

12 December 2020

Optic nerve injury alters basic fibroblast growth factor localization in the retina and optic tract

1 reference

12 December 2020

Ganglion cell distribution in the retina of the mouse

1 reference

12 December 2020

Experimental induction of retinal ganglion cell death in adult mice

1 reference

12 December 2020

Identifiers

DOI

10.1167/IOVS.11-8646

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22395888%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22395888%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

PubMed publication ID

22395888

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22395888%20AND%20SRC:MED&resulttype=core&format=json