Lactosylceramide: a lipid second messenger in neuroinflammatory disease (Q36994594)

17 August 2017

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title

Lactosylceramide: a lipid second messenger in neuroinflammatory disease (English)

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β-D-galactosyl-(1→4)-β-D-glucosyl-(1↔1)-N-acylsphingosine (R1)

17 August 2017

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ChEBI release 2020-05-28

Je-Seong Won

1

1 reference

17 August 2017

Avtar K Singh

series ordinal

2

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17 August 2017

Inderjit Singh

series ordinal

3

1 reference

17 August 2017

language of work or name

English

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publication date

1 November 2007

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Journal of Neurochemistry

17 August 2017

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17 August 2017

103 Suppl 1

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17 August 2017

180-191

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A novel cytoplasmic domain of the p55 tumor necrosis factor receptor initiates the neutral sphingomyelinase pathway

17 August 2017

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04822.X

Human lysosomal sphingomyelinase: substrate efficacy of apolipoprotein/sphingomyelin complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04822.X

A family of human beta4-galactosyltransferases. Cloning and expression of two novel UDP-galactose:beta-n-acetylglucosamine beta1, 4-galactosyltransferases, beta4Gal-T2 and beta4Gal-T3

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04822.X

Extracellular release of newly synthesized sphingosine-1-phosphate by cerebellar granule cells and astrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04822.X

Inflammatory mediator and beta-amyloid (25-35)-induced ceramide generation and iNOS expression are inhibited by vitamin E.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04822.X

Sphingosine-1-phosphate is released by cerebellar astrocytes in response to bFGF and induces astrocyte proliferation through Gi-protein-coupled receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04822.X

Purification and characterization of a magnesium-dependent neutral sphingomyelinase from bovine brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04822.X

Overexpression of protein kinase Czeta confers protection against antileukemic drugs by inhibiting the redox-dependent sphingomyelinase activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04822.X

Phosphoinositide 3-kinase regulates crosstalk between Trk A tyrosine kinase and p75(NTR)-dependent sphingolipid signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04822.X

Current molecular models for NADPH oxidase regulation by Rac GTPase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04822.X

Structure and function of sphingolipid- and cholesterol-rich membrane rafts

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04822.X

Sphingosine 1-phosphate and ceramide 1-phosphate: expanding roles in cell signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04822.X

Asymmetric addition of ceramides but not dihydroceramides promotes transbilayer (flip-flop) lipid motion in membranes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04822.X

Role of sphingomyelinase and ceramide in modulating rafts: do biophysical properties determine biologic outcome?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04822.X

Role of multiple drug resistance protein 1 in neutral but not acidic glycosphingolipid biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04822.X

Peroxynitrite and mitochondrial dysfunction in the pathogenesis of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04822.X

The reconstituted P-glycoprotein multidrug transporter is a flippase for glucosylceramide and other simple glycosphingolipids

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04822.X

Distinct sites of action of Bcl-2 and Bcl-xL in the ceramide pathway of apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04822.X

Intracellular trafficking of sphingolipids: relationship to biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04822.X

The ins and outs of sphingolipid synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04822.X

S-adenosylmethionine regulates MAT1A and MAT2A gene expression in cultured rat hepatocytes: a new role for S-adenosylmethionine in the maintenance of the differentiated status of the liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04822.X

Sphingosine-1-phosphate inhibits acid sphingomyelinase and blocks apoptosis in macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04822.X

Clustering of CD40 ligand is required to form a functional contact with CD40.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04822.X

C26-CoA-dependent ceramide synthesis of Saccharomyces cerevisiae is operated by Lag1p and Lac1p

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04822.X

Ceramide and cell death receptor clustering

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04822.X

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04822.X

Substantial sulfatide deficiency and ceramide elevation in very early Alzheimer's disease: potential role in disease pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04822.X

Molecular machinery for non-vesicular trafficking of ceramide

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04822.X

Inducible nitric oxide synthase (iNOS) and regulation of leucocyte/endothelial cell interactions: studies in iNOS-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04822.X

Cloning and characterization of the mammalian brain-specific, Mg2+-dependent neutral sphingomyelinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04822.X

Acid sphingomyelinase deficient mice: a model of types A and B Niemann-Pick disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04822.X

Glucosylceramide synthase and glycosphingolipid synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04822.X

Expression cloning of a cDNA for human ceramide glucosyltransferase that catalyzes the first glycosylation step of glycosphingolipid synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04822.X

Cooperativity between oxidants and tumor necrosis factor in the activation of nuclear factor (NF)-kappaB: requirement of Ras/mitogen-activated protein kinases in the activation of NF-kappaB by oxidants

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04822.X

Central nervous system inflammation is a hallmark of pathogenesis in mouse models of GM1 and GM2 gangliosidosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04822.X

Carbohydrate-mediated cell adhesion in cancer metastasis and angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04822.X

Essential roles of sphingosine 1-phosphate/S1P1 receptor axis in the migration of neural stem cells toward a site of spinal cord injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04822.X

Cytokine induction of NO synthase II in human DLD-1 cells: roles of the JAK-STAT, AP-1 and NF-kappaB-signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04822.X

Platelet derived growth factor recruits lactosylceramide to induce cell proliferation in UDP Gal:GlcCer: beta1 --> 4Galactosyltransferase (GalT-V) mutant Chinese hamster ovary cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04822.X

Control of ceramide-induced apoptosis by IGF-1: involvement of PI-3 kinase, caspase-3 and catalase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04822.X

Elevation of de novo ceramide synthesis in tumor masses and the role of microsomal dihydroceramide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04822.X

Defects in cell growth regulation by C18:0-ceramide and longevity assurance gene 1 in human head and neck squamous cell carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04822.X

Impaired neutral sphingomyelinase activation and cutaneous barrier repair in FAN-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04822.X

CERT mediates intermembrane transfer of various molecular species of ceramides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04822.X

Molecular mechanisms of dexamethasone inhibition of nitric oxide synthase expression in interleukin 1 beta-stimulated mesangial cells: evidence for the involvement of transcriptional and posttranscriptional regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04822.X

Nox/Duox family of nicotinamide adenine dinucleotide (phosphate) oxidases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04822.X

Ceramide-1-phosphate: the "missing" link in eicosanoid biosynthesis and inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04822.X

Accumulation of glucosylceramides in multidrug-resistant cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04822.X

Amyloid-beta peptide induces oligodendrocyte death by activating the neutral sphingomyelinase-ceramide pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04822.X

The expanding beta 4-galactosyltransferase gene family: messages from the databanks

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04822.X

Acid and neutral sphingomyelinases: roles and mechanisms of regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04822.X

Biochemical properties of mammalian neutral sphingomyelinase 2 and its role in sphingolipid metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04822.X

Endocytosis and sorting of glycosphingolipids in sphingolipid storage disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04822.X

Lactosylceramide is required in apoptosis induced by N-Smase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04822.X

Characterization of a ceramide-activated protein kinase: stimulation by tumor necrosis factor alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04822.X

Mammalian Lass6 and its related family members regulate synthesis of specific ceramides

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04822.X

Glucocerebroside inhibits NADPH oxidase activation in cell-free system

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04822.X

Cloning and sequencing of cDNA of bovine N-acetylglucosamine (beta 1-4)galactosyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04822.X

Assembly of the phagocyte NADPH oxidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04822.X

Bcl-xL interrupts oxidative activation of neutral sphingomyelinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04822.X

Sphingomyelinase and ceramide stimulate the expression of inducible nitric-oxide synthase in rat primary astrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04822.X

A novel role of lactosylceramide in the regulation of lipopolysaccharide/interferon-gamma-mediated inducible nitric oxide synthase gene expression: implications for neuroinflammatory diseases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04822.X

A novel role of lactosylceramide in the regulation of tumor necrosis factor alpha-mediated proliferation of rat primary astrocytes. Implications for astrogliosis following neurotrauma

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04822.X

S6 kinase p90rsk in granulocyte-macrophage colony-stimulating factor-stimulated proliferative and mature hematopoietic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04822.X

Molecular mechanisms and regulation of ceramide transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04822.X

Ceramide: an endogenous regulator of apoptosis and growth suppression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04822.X

Novel role of lactosylceramide in vascular endothelial growth factor-mediated angiogenesis in human endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04822.X

Involvement of NADPH oxidase isoforms and Src family kinases in CD95-dependent hepatocyte apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04822.X

Lipid pickup and delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04822.X

Sphingosine 1-phosphate and its receptors: an autocrine and paracrine network

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04822.X

Molecular cloning of a human cDNA encoding beta-1,4-galactosyltransferase with 37% identity to mammalian UDP-Gal:GlcNAc beta-1,4-galactosyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04822.X

Function of the cloned putative neutral sphingomyelinase as lyso-platelet activating factor-phospholipase C

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04822.X

Zn2+-stimulated sphingomyelinase is secreted by many cell types and is a product of the acid sphingomyelinase gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04822.X

Lag1p and Lac1p are essential for the Acyl-CoA-dependent ceramide synthase reaction in Saccharomyces cerevisae

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04822.X

The CLN9 protein, a regulator of dihydroceramide synthase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04822.X

Cloning of a novel member of the UDP-galactose:beta-N-acetylglucosamine beta1,4-galactosyltransferase family, beta4Gal-T4, involved in glycosphingolipid biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04822.X

CD40 signals apoptosis through FAN-regulated activation of the sphingomyelin-ceramide pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04822.X

Bovine galactosyltransferase: identification of a clone by direct immunological screening of a cDNA expression library

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04822.X

Lipid rafts and signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04822.X

Cytokine-mediated induction of ceramide production is redox-sensitive. Implications to proinflammatory cytokine-mediated apoptosis in demyelinating diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04822.X

Sphingosine kinase: biochemical and cellular regulation and role in disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04822.X

Ceramide generation in nitric oxide-induced apoptosis. Activation of magnesium-dependent neutral sphingomyelinase via caspase-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04822.X

Ceramide/sphingosine/sphingosine 1-phosphate metabolism on the cell surface and in the extracellular space

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04822.X

Cloned mammalian neutral sphingomyelinase: functions in sphingolipid signaling?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04822.X

Ceramide as a second messenger: sticky solutions to sticky problems

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04822.X

DNA deaminating ability and genotoxicity of nitric oxide and its progenitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04822.X

Sphingolipid signaling and redox regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04822.X

Dual role of cAMP in iNOS expression in glial cells and macrophages is mediated by differential regulation of p38-MAPK/ATF-2 activation and iNOS stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04822.X

The role of neutral sphingomyelinase produced ceramide in lipopolysaccharide-mediated expression of inducible nitric oxide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04822.X

Endostatin uncouples NO and Ca2+ response to bradykinin through enhanced O2*- production in the intact coronary endothelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04822.X

CD95 Signaling via Ceramide-rich Membrane Rafts

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.04822.X

10.1111/J.1471-4159.2007.04822.X

21 January 2018

Identifiers

DOI

1 reference

17 August 2017

1 reference