Tumour targeting by microtubule-depolymerizing vascular disrupting agents (Q37008845)

17 August 2017

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title

Tumour targeting by microtubule-depolymerizing vascular disrupting agents (English)

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17 August 2017

2

Gillian M Tozer

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17 August 2017

Chryso Kanthou

1

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17 August 2017

language of work or name

English

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publication date

1 November 2007

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Expert Opinion on Therapeutic Targets

17 August 2017

published in

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17 August 2017

volume

11

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17 August 2017

issue

11

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17 August 2017

page(s)

1443-1457

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What Is the Evidence That Tumors Are Angiogenesis Dependent?

17 August 2017

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Tumour vascular targeting

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Vascular targeting agents enhance chemotherapeutic agent activities in solid tumor therapy

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Combretastatin family member OXI4503 induces tumor vascular collapse through the induction of endothelial apoptosis

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Combretastatin A4 phosphate has tumor antivascular activity in rat and man as demonstrated by dynamic magnetic resonance imaging

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Microtubules as a target for anticancer drugs

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Dynamic instability of microtubule growth

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Functional cooperation between the microtubule and actin cytoskeletons

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Rho family proteins: coordinating cell responses

21 January 2018

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The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

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Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase)

21 January 2018

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Myosin light chain kinase: an actin-binding protein that regulates an ATP-dependent interaction with myosin

21 January 2018

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SAPK2/p38-dependent F-actin reorganization regulates early membrane blebbing during stress-induced apoptosis

21 January 2018

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Active ERK/MAP kinase is targeted to newly forming cell-matrix adhesions by integrin engagement and v-Src

21 January 2018

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Extracellular signal-regulated kinase mediates phosphorylation of tropomyosin-1 to promote cytoskeleton remodeling in response to oxidative stress: impact on membrane blebbing

21 January 2018

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Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton

21 January 2018

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Dysregulation of the endothelial cellular response to oxidative stress in cancer

21 January 2018

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Selective activation of p38 MAPK cascade and mitotic arrest caused by low level oxidative stress

21 January 2018

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MZ3 induces apoptosis in human leukemia cells.

21 January 2018

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Rho GTPases and the regulation of endothelial permeability

21 January 2018

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Endothelial cell-to-cell junctions: molecular organization and role in vascular homeostasis

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21 January 2018

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21 January 2018

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Nucleotide exchange factor GEF-H1 mediates cross-talk between microtubules and the actin cytoskeleton

21 January 2018

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Microtubule depolymerization rapidly collapses capillary tube networks in vitro and angiogenic vessels in vivo through the small GTPase Rho.

21 January 2018

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Vascular targeting effect of combretastatin A-4 phosphate dominates the inherent angiogenesis inhibitory activity

21 January 2018

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Rac regulates endothelial morphogenesis and capillary assembly

21 January 2018

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Multifaceted role of Rho proteins in angiogenesis

21 January 2018

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Temporal and spatial modulation of Rho GTPases during in vitro formation of capillary vascular network. Adherens junctions and myosin light chain as targets of Rac1 and RhoA.

21 January 2018

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Involvement of RhoA/Rho kinase signaling in VEGF-induced endothelial cell migration and angiogenesis in vitro

21 January 2018

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Matrix-specific activation of Src and Rho initiates capillary morphogenesis of endothelial cells

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.11.11.1443

Rho activity critically and selectively regulates endothelial cell organization during angiogenesis

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.11.11.1443

Regulation of microtubule dynamics in 3T3 fibroblasts by Rho family GTPases

21 January 2018

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Rho guanosine triphosphatase mediates the selective stabilization of microtubules induced by lysophosphatidic acid

21 January 2018

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mDia mediates Rho-regulated formation and orientation of stable microtubules

21 January 2018

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Conserved microtubule-actin interactions in cell movement and morphogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1443

Selective stabilization of microtubules oriented toward the direction of cell migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1443

Localized stabilization of microtubules by integrin- and FAK-facilitated Rho signaling

21 January 2018

1 reference

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Actin and microtubules in cell motility: which one is in control?

21 January 2018

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The tubulin-binding agent combretastatin A-4-phosphate arrests endothelial cells in mitosis and induces mitotic cell death

21 January 2018

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The spindle assembly checkpoint

21 January 2018

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Schedule dependence of combretastatin A4 phosphate in transplanted and spontaneous tumour models

21 January 2018

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Signaling mechanisms regulating endothelial permeability

21 January 2018

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RhoGDI-1 modulation of the activity of monomeric RhoGTPase RhoA regulates endothelial barrier function in mouse lungs

21 January 2018

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Microvascular mechanisms by which the combretastatin A-4 derivative AC7700 (AVE8062) induces tumour blood flow stasis

21 January 2018

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Rocks: multifunctional kinases in cell behaviour

21 January 2018

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Phase I clinical evaluation of weekly administration of the novel vascular-targeting agent, ZD6126, in patients with solid tumors.

21 January 2018

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On the origin and nature of elevated levels of circulating endothelial cells after treatment with a vascular disrupting agent.

21 January 2018

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Determinants of anti-vascular action by combretastatin A-4 phosphate: role of nitric oxide

21 January 2018

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Molecular regulation of vessel maturation

21 January 2018

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Rac and Rho play opposing roles in the regulation of hypoxia/reoxygenation-induced permeability changes in pulmonary artery endothelial cells

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.11.11.1443

Rac1 and RhoA as regulators of endothelial phenotype and barrier function in hypoxia-induced neonatal pulmonary hypertension

21 January 2018

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Hypoxia and the regulation of mitogen-activated protein kinases: gene transcription and the assessment of potential pharmacologic therapeutic interventions

21 January 2018

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Endothelial-cell proliferation in experimental tumours

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.11.11.1443

Genes expressed in human tumor endothelium

21 January 2018

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Anti-vascular agent Combretastatin A-4-P modulates hypoxia inducible factor-1 and gene expression

21 January 2018

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Infiltrating neutrophils mediate the initial angiogenic switch in a mouse model of multistage carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1443

Microtubule growth activates Rac1 to promote lamellipodial protrusion in fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1443

Regulation of leading edge microtubule and actin dynamics downstream of Rac1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1443

ERK-MAPK signaling opposes Rho-kinase to promote endothelial cell survival and sprouting during angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1443

10.1517/14728222.11.11.1443

21 January 2018

Identifiers

DOI

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17 August 2017

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