Cytochrome P450/redox partner fusion enzymes: biotechnological and toxicological prospects (Q37008895)

17 August 2017

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title

Cytochrome P450/redox partner fusion enzymes: biotechnological and toxicological prospects (English)

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17 August 2017

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2

Hazel M Girvan

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17 August 2017

Kirsty J McLean

1

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17 August 2017

Andrew W Munro

series ordinal

3

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17 August 2017

language of work or name

English

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publication date

1 December 2007

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Expert Opinion on Drug Metabolism & Toxicology

17 August 2017

published in

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17 August 2017

volume

3

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17 August 2017

issue

6

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17 August 2017

page(s)

847-863

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Cytochrome P450--redox partner fusion enzymes.

17 August 2017

cites work

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Polymorphic hydroxylation of Debrisoquine in man.

21 January 2018

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Identification of human CYP forms involved in the activation of tamoxifen and irreversible binding to DNA.

21 January 2018

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Bacterial cytochromes P-450.

21 January 2018

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Spin state control of the hepatic cytochrome P450 redox potential

21 January 2018

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Redox control of the catalytic cycle of flavocytochrome P-450 BM3.

21 January 2018

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Structure and chemistry of cytochrome P450.

21 January 2018

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Cytochrome p450 compound I.

21 January 2018

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P450 BM3: the very model of a modern flavocytochrome

21 January 2018

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Electron transfer by diflavin reductases.

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.3.6.847

NADPH-cytochrome P450 oxidoreductase. Structural basis for hydride and electron transfer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.6.847

Variations on a (t)heme--novel mechanisms, redox partners and catalytic functions in the cytochrome P450 superfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.6.847

Expression and characterization of the two flavodoxin proteins of Bacillus subtilis, YkuN and YkuP: biophysical properties and interactions with cytochrome P450 BioI.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.6.847

Expression, purification and characterisation of a Bacillus subtilis ferredoxin: a potential electron transfer donor to cytochrome P450 BioI.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.6.847

Crystal Structure of Putidaredoxin, the [2Fe–2S] Component of the P450cam Monooxygenase System from Pseudomonas putida

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.6.847

Nitric oxide reductase (P450nor) from Fusarium oxysporum

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.6.847

Unique heme environment at the putative distal region of hydrogen peroxide-dependent fatty acid alpha-hydroxylase from Sphingomonas paucimobilis (peroxygenase P450(SPalpha).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.6.847

A novel sterol 14alpha-demethylase/ferredoxin fusion protein (MCCYP51FX) from Methylococcus capsulatus represents a new class of the cytochrome P450 superfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.6.847

An explosive-degrading cytochrome P450 activity and its targeted application for the phytoremediation of RDX.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.6.847

Domains of the catalytically self-sufficient cytochrome P-450 BM-3. Genetic construction, overexpression, purification and spectroscopic characterization

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.6.847

Expression, purification, and characterization of Bacillus subtilis cytochromes P450 CYP102A2 and CYP102A3: flavocytochrome homologues of P450 BM3 from Bacillus megaterium

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.6.847

A novel class of self-sufficient cytochrome P450 monooxygenases in prokaryotes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.6.847

Role of the linker region connecting the reductase and heme domains in cytochrome P450BM-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.6.847

A self-sufficient cytochrome p450 with a primary structural organization that includes a flavin domain and a [2Fe-2S] redox center

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.6.847

Probing electron transfer in flavocytochrome P-450 BM3 and its component domains.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.6.847

Structural and enzymological analysis of the interaction of isolated domains of cytochrome P-450 BM3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.6.847

An unusual yet strongly conserved flavoprotein reductase in bacteria and mammals

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.6.847

The domain architecture of cytochrome P450BM-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.6.847

Dissection of NADPH-cytochrome P450 oxidoreductase into distinct functional domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.6.847

The structure of the cytochrome p450BM-3 haem domain complexed with the fatty acid substrate, palmitoleic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.6.847

Pivotal role of water in the mechanism of P450BM-3

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.6.847

Flavocytochrome P450 BM3 mutant A264E undergoes substrate-dependent formation of a novel heme iron ligand set.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.6.847

A single mutation in cytochrome P450 BM3 induces the conformational rearrangement seen upon substrate binding in the wild-type enzyme.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.6.847

Structural and spectroscopic characterization of P450 BM3 mutants with unprecedented P450 heme iron ligand sets. New heme ligation states influence conformational equilibria in P450 BM3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.6.847

The dimeric form of flavocytochrome P450 BM3 is catalytically functional as a fatty acid hydroxylase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.6.847

Domain swapping in inducible nitric-oxide synthase. Electron transfer occurs between flavin and heme groups located on adjacent subunits in the dimer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.6.847

The role of Thr268 in oxygen activation of cytochrome P450BM-3

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.6.847

Phenylalanine 393 exerts thermodynamic control over the heme of flavocytochrome P450 BM3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.6.847

Adaptive responses to fatty acids are mediated by the regulated expression of cytochromes P450.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.6.847

Kinetic analysis of hydroxylation of saturated fatty acids by recombinant P450foxy produced by an Escherichia coli expression system

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.6.847

Characterization of four clustered and coregulated genes associated with fumonisin biosynthesis in Fusarium verticillioides

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.6.847

Protein engineering of Bacillus megaterium CYP102. The oxidation of polycyclic aromatic hydrocarbons

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.6.847

Direct conversion of ethane to ethanol by engineered cytochrome P450 BM3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.6.847

Regio- and enantioselective alkane hydroxylation with engineered cytochromes P450 BM-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.6.847

Enantioselective epoxidation of terminal alkenes to (R)- and (S)-epoxides by engineered cytochromes P450 BM-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.6.847

Laboratory evolution of cytochrome p450 BM-3 monooxygenase for organic cosolvents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.6.847

Laboratory evolution of a soluble, self-sufficient, highly active alkane hydroxylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.6.847

Altering the regioselectivity of cytochrome P450 CYP102A3 of Bacillus subtilis by using a new versatile assay system

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.6.847

Engineering the substrate specificity of cytochrome P450 CYP102A2 by directed evolution: production of an efficient enzyme for bioconversion of fine chemicals.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.6.847

Rational evolution of a medium chain-specific cytochrome P-450 BM-3 variant.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.6.847

Biotransformation of the sesquiterpene (+)-valencene by cytochrome P450cam and P450BM-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.6.847

Metabolism of polychlorinated dibenzo-p-dioxins by cytochrome P450 BM-3 and its mutant

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.6.847

Indole hydroxylation by bacterial cytochrome P450 BM-3 and modulation of activity by cumene hydroperoxide

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.6.847

Engineering of cytochrome P450 3A4 for enhanced peroxide-mediated substrate oxidation using directed evolution and site-directed mutagenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.6.847

Engineering mammalian cytochrome P450 2B1 by directed evolution for enhanced catalytic tolerance to temperature and dimethyl sulfoxide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.6.847

Protein engineering of cytochromes P-450.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.6.847

Update on mechanism and catalytic regulation in the NO synthases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.6.847

High-level expression in Escherichia coli of enzymatically active fusion proteins containing the domains of mammalian cytochromes P450 and NADPH-P450 reductase flavoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.6.847

Biochemical characterization of lauric acid omega-hydroxylation by a CYP4A1/NADPH-cytochrome P450 reductase fusion protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.6.847

Construction of a human cytochrome P450 1A1: rat NADPH-cytochrome P450 reductase fusion protein cDNA and expression in Escherichia coli, purification, and catalytic properties of the enzyme in bacterial cells and after purification.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.6.847

Expression, purification, and characterization of a catalytically active human cytochrome P450 1A2:rat NADPH-cytochrome P450 reductase fusion protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.6.847

Expression, purification, and biochemical characterization of a human cytochrome P450 CYP2D6-NADPH cytochrome P450 reductase fusion protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.6.847

Engineering human cytochrome P450 enzymes into catalytically self-sufficient chimeras using molecular Lego.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.6.847

Catalytically functional flavocytochrome chimeras of P450 BM3 and nitric oxide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.6.847

Reconstitution of the enzymatic activities of cytochrome P450s using recombinant flavocytochromes containing rat cytochrome b(5) fused to NADPH--cytochrome P450 reductase with various membrane-binding segments

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.6.847

Expression, purification, and physical properties of recombinant flavocytochrome fusion proteins containing rat cytochrome b(5) linked to NADPH-cytochrome P450 reductase by different membrane-binding segments

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.6.847

Putidaredoxin reductase-putidaredoxin-cytochrome p450cam triple fusion protein. Construction of a self-sufficient Escherichia coli catalytic system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.6.847

Probing the structure of the linker connecting the reductase and heme domains of cytochrome P450BM-3 using site-directed mutagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.6.847

Cholesterol 7alpha-hydroxylase is phosphorylated at multiple amino acids.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.6.847

Peroxynitrite and protein tyrosine nitration of prostacyclin synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.6.847

Interaction of nitric oxide with cytochrome P450 BM3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.6.847

NADPH oxidase activity of cytochrome P-450 BM3 and its constituent reductase domain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.6.847

Preparation of human metabolites of propranolol using laboratory-evolved bacterial cytochromes P450.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.6.847

Enantioselective alpha-hydroxylation of 2-arylacetic acid derivatives and buspirone catalyzed by engineered cytochrome P450 BM-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.6.847

Cytochromes P450 as versatile biocatalysts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.6.847

Neutral thiol as a proximal ligand to ferrous heme iron: implications for heme proteins that lose cysteine thiolate ligation on reduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.6.847

Rapid P450 heme iron reduction by laser photoexcitation of Mycobacterium tuberculosis CYP121 and CYP51B1. Analysis of CO complexation reactions and reversibility of the P450/P420 equilibrium.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.6.847

Autocatalytic mechanism and consequences of covalent heme attachment in the cytochrome P4504A family

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.6.847

Progress towards the easier use of P450 enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.6.847

Co-expression of P450 BM3 and glucose dehydrogenase by recombinant Escherichia coli and its application in an NADPH-dependent indigo production system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.6.847

Switching pyridine nucleotide specificity in P450 BM3: mechanistic analysis of the W1046H and W1046A enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.6.847

Metabolic activation of polycyclic aromatic hydrocarbons to carcinogens by cytochromes P450 1A1 and 1B1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.6.847

Cytochrome P4502C9: an enzyme of major importance in human drug metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.6.847

Crystal structure of human cytochrome P450 2C9 with bound warfarin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.6.847

Probing the substrate specificity of the catalytically self-sufficient cytochrome P450 RhF from a Rhodococcus sp

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.6.847

Identification of Critical Residues in Novel Drug Metabolizing Mutants of Cytochrome P450 BM3 Using Random Mutagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.6.847

A Single Mutation in Cytochrome P450 BM3 Changes Substrate Orientation in a Catalytic Intermediate and the Regiospecificity of Hydroxylation†

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.6.847

21 January 2018

Identifiers

DOI

10.1517/17425255.3.6.847

1 reference

17 August 2017

1 reference