WRN protects against topo I but not topo II inhibitors by preventing DNA break formation (Q37021622)

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14 January 2020

title

WRN protects against topo I but not topo II inhibitors by preventing DNA break formation (English)

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14 January 2020

4

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author name string

Markus Christmann

1

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14 January 2020

Maja T Tomicic

2

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14 January 2020

Christopher Gestrich

3

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14 January 2020

Vilhelm A Bohr

5

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Bernd Kaina

6

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publication date

15 October 2008

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14 January 2020

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14 January 2020

volume

7

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issue

12

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14 January 2020

page(s)

1999-2009

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Werner syndrome protein prevents DNA breaks upon chromatin structure alteration

14 January 2020

cites work

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WRN counteracts the NHEJ pathway upon camptothecin exposure

29 September 2017

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Werner syndrome protein participates in a complex with RAD51, RAD54, RAD54B and ATR in response to ICL-induced replication arrest

29 September 2017

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Hereditary ataxia SCAN1 cells are defective for the repair of transcription-dependent topoisomerase I cleavage complexes

29 September 2017

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Collaboration of Werner syndrome protein and BRCA1 in cellular responses to DNA interstrand cross-links

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The Werner syndrome protein operates in base excision repair and cooperates with DNA polymerase beta

29 September 2017

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SCAN1 mutant Tdp1 accumulates the enzyme--DNA intermediate and causes camptothecin hypersensitivity

29 September 2017

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Deficient DNA repair in the human progeroid disorder, Werner syndrome

29 September 2017

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p53 modulates RPA-dependent and RPA-independent WRN helicase activity

29 September 2017

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TDP1 overexpression in human cells counteracts DNA damage mediated by topoisomerases I and II

29 September 2017

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Genetic evidence for involvement of two distinct nonhomologous end-joining pathways in repair of topoisomerase II-mediated DNA damage

29 September 2017

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p53 stimulates human topoisomerase I activity by modulating its DNA binding.

29 September 2017

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29 September 2017

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Reduced apoptotic response to camptothecin in CHO cells deficient in XRCC3.

29 September 2017

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Nonlinear partial differential equations and applications: The mechanism of topoisomerase I poisoning by a camptothecin analog

29 September 2017

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Repair of topoisomerase I covalent complexes in the absence of the tyrosyl-DNA phosphodiesterase Tdp1.

29 September 2017

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Homologous recombination resolution defect in werner syndrome

29 September 2017

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Phosphorylation of mismatch repair proteins MSH2 and MSH6 affecting MutSalpha mismatch-binding activity

29 September 2017

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Werner's syndrome protein is required for correct recovery after replication arrest and DNA damage induced in S-phase of cell cycle

29 September 2017

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Ubiquitin/26S proteasome-mediated degradation of topoisomerase I as a resistance mechanism to camptothecin in tumor cells.

29 September 2017

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p53 Modulates the exonuclease activity of Werner syndrome protein

29 September 2017

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Werner helicase relocates into nuclear foci in response to DNA damaging agents and co-localizes with RPA and Rad51.

29 September 2017

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DNA double-strand breaks associated with replication forks are predominantly repaired by homologous recombination involving an exchange mechanism in mammalian cells

29 September 2017

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Werner's syndrome cell lines are hypersensitive to camptothecin-induced chromosomal damage

29 September 2017

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Werner syndrome lymphoblastoid cells are sensitive to camptothecin-induced apoptosis in S-phase

29 September 2017

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Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexes

29 September 2017

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A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Mechanisms of cell killing by drugs that trap covalent complexes between DNA topoisomerases and DNA.

27 June 2018

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27 June 2018

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Topotecan-triggered degradation of topoisomerase I is p53-dependent and impacts cell survival

27 June 2018

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Structures of three classes of anticancer agents bound to the human topoisomerase I-DNA covalent complex

4 September 2018

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Werner protein stimulates topoisomerase I DNA relaxation activity

4 September 2018

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Association of XRCC1 and tyrosyl DNA phosphodiesterase (Tdp1) for the repair of topoisomerase I-mediated DNA lesions

4 September 2018

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Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes.

4 September 2018

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Apoptosis induced by (E)-5-(2-bromovinyl)-2'-deoxyuridine in varicella zoster virus thymidine kinase-expressing cells is driven by activation of c-Jun/activator protein-1 and Fas ligand/caspase-8.

4 September 2018

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Comparative analysis of DNA breakage, chromosomal aberrations and apoptosis induced by the anti-herpes purine nucleoside analogues aciclovir, ganciclovir and penciclovir

4 September 2018

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X-ray repair cross-complementing gene I protein plays an important role in camptothecin resistance

4 September 2018

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DNA polymerase beta mediates protection of mammalian cells against ganciclovir-induced cytotoxicity and DNA breakage.

4 September 2018

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Arrest of replication forks by drug-stabilized topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by camptothecin

4 September 2018

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12 December 2020

Involvement of nucleic acid synthesis in cell killing mechanisms of topoisomerase poisons

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12 December 2020

Ubiquitin-dependent destruction of topoisomerase I is stimulated by the antitumor drug camptothecin

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12 December 2020

Delayed kinetics of DNA double-strand break processing in normal and pathological aging

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12 December 2020

On the mechanism of topoisomerase I inhibition by camptothecin: evidence for binding to an enzyme-DNA complex

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12 December 2020

Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I

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12 December 2020

10.1016/J.DNAREP.2008.08.008

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18805512%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

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14 January 2020

PubMed publication ID

18805512

1 reference