Is IDO a key enzyme bridging the gap between tumor escape and tolerance induction? (Q37026760)

17 August 2017

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title

Is IDO a key enzyme bridging the gap between tumor escape and tolerance induction? (English)

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17 August 2017

Stefan Löb

1

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PubMed ID

18064486

17 August 2017

Alfred Königsrainer

series ordinal

2

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PubMed ID

18064486

17 August 2017

language of work or name

English

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publication date

4 December 2007

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Langenbeck's Archives of Surgery

17 August 2017

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17 August 2017

393

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17 August 2017

995-1003

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17 August 2017

6

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https://scigraph.springernature.com/pub.10.1007/s00423-007-0245-7

17 August 2017

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1-Methyl-tryptophan can interfere with TLR signaling in dendritic cells independently of IDO activity

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Implications of interferon-induced tryptophan catabolism in cancer, auto-immune diseases and AIDS.

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Potential regulatory function of human dendritic cells expressing indoleamine 2,3-dioxygenase

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The immunoregulatory role of IDO-producing human dendritic cells revisited.

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Redox reactions related to indoleamine 2,3-dioxygenase and tryptophan metabolism along the kynurenine pathway

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Tryptophan and the immune response

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Natural selection of tumor variants in the generation of "tumor escape" phenotypes

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Modulation of tryptophan catabolism by regulatory T cells.

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Quinolinic acid immunoreactive cells in the choroid plexus, leptomeninges and brain vasculature of the immune-stimulated gerbil

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Specific subsets of murine dendritic cells acquire potent T cell regulatory functions following CTLA4-mediated induction of indoleamine 2,3 dioxygenase

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Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase

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Tryptophan catabolism prevents maternal T cells from activating lethal anti-fetal immune responses.

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Prognostic value of indoleamine 2,3-dioxygenase expression in colorectal cancer: effect on tumor-infiltrating T cells.

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Intratumor depletion of CD4+ cells unmasks tumor immunogenicity leading to the rejection of late-stage tumors

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Prevention of allogeneic fetal rejection by tryptophan catabolism

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The interaction properties of costimulatory molecules revisited.

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Tryptophan degradation during and after gestation

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Regulation of human auto- and alloreactive T cells by indoleamine 2,3-dioxygenase (IDO)-producing dendritic cells: too much ado about IDO?

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Characteristics of interferon induced tryptophan metabolism in human cells in vitro

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Inhibition of indoleamine 2,3-dioxygenase, an immunoregulatory target of the cancer suppression gene Bin1, potentiates cancer chemotherapy.

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The complementary roles of deletion and regulation in transplantation tolerance

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Immunosuppressive networks in the tumour environment and their therapeutic relevance

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Does the immune system see tumors as foreign or self?

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CD8(+) tumor-infiltrating T cells are deficient in perforin-mediated cytolytic activity due to defective microtubule-organizing center mobilization and lytic granule exocytosis

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Utilization of superoxide anion by indoleamine oxygenase-catalyzed tryptophan and indoleamine oxidation.

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Pattern of recruitment of immunoregulatory antigen-presenting cells in malignant melanoma.

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The concept of immunological surveillance

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Expression of indoleamine 2,3-dioxygenase by plasmacytoid dendritic cells in tumor-draining lymph nodes.

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MHC class I down-regulation: tumour escape from immune surveillance? (review).

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Costimulation blockade with belatacept in renal transplantation

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Type, density, and location of immune cells within human colorectal tumors predict clinical outcome

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Tryptophan catabolism and T-cell tolerance: immunosuppression by starvation?

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Tolerance, DCs and tryptophan: much ado about IDO

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Studying the immunosuppressive role of indoleamine 2,3-dioxygenase: tryptophan metabolites suppress rat allogeneic T-cell responses in vitro and in vivo

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Characterisation of L-tryptophan transporters in human placenta: a comparison of brush border and basal membrane vesicles

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Indoleamine 2,3-dioxygenase is a novel prognostic indicator for endometrial cancer

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Indoleamine 2,3-dioxygenase expression in patients with acute graft-versus-host disease after allogeneic stem cell transplantation and in pregnant women: association with the induction of allogeneic immune tolerance?

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12 December 2020

Interferon gamma blocks the growth of Toxoplasma gondii in human fibroblasts by inducing the host cells to degrade tryptophan

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12 December 2020

Are indoleamine-2,3-dioxygenase producing human dendritic cells a tool for suppression of allogeneic T-cell responses?

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12 December 2020

Modulation of tryptophan catabolism by human leukemic cells results in the conversion of CD25- into CD25+ T regulatory cells

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12 December 2020

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12 December 2020

Indoleamine 2,3-dioxygenase contributes to tumor cell evasion of T cell-mediated rejection.

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12 December 2020

Inhibition of allogeneic T cell proliferation by indoleamine 2,3-dioxygenase-expressing dendritic cells: mediation of suppression by tryptophan metabolites

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Down-Regulation of CD25 Expression on the Surface of Activated Tumor-Infiltrating Lymphocytes in Human Cervical Carcinoma

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Monocyte-mediated T-cell suppression and augmented monocyte tryptophan catabolism after human hematopoietic stem-cell transplantation

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12 December 2020

Effects of immune activation on quinolinic acid and neuroactive kynurenines in the mouse

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Novel tryptophan catabolic enzyme IDO2 is the preferred biochemical target of the antitumor indoleamine 2,3-dioxygenase inhibitory compound D-1-methyl-tryptophan

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12 December 2020

Inhibitors of human indoleamine 2,3-dioxygenase identified with a target-based screen in yeast

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12 December 2020

Increasing tumor antigen expression overcomes "ignorance" to solid tumors via crosspresentation by bone marrow-derived stromal cells

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12 December 2020

Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion

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12 December 2020

Studies on indoleamine 2,3-dioxygenase. I. Superoxide anion as substrate

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12 December 2020

Repression of interleukin-2 mRNA translation in primary human breast carcinoma tumor-infiltrating lymphocytes

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12 December 2020

10.1007/S00423-007-0245-7

Identifiers

DOI

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17 August 2017

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PubMed ID

18064486